ID H3AX12_LATCH Unreviewed; 1924 AA.
AC H3AX12;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=DENN domain containing 4A {ECO:0000313|Ensembl:ENSLACP00000014183.1};
GN Name=DENND4A {ECO:0000313|Ensembl:ENSLACP00000014183.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000014183.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000014183.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01023683; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01023684; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01023685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01023686; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01023687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01023688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01023689; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01023690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01023691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01023692; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSLACT00000014282.1; ENSLACP00000014183.1; ENSLACG00000012485.1.
DR GeneTree; ENSGT00940000155836; -.
DR HOGENOM; CLU_003074_0_0_1; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000012485; Expressed in chordate pharynx and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.100.10.50; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR023341; MABP.
DR InterPro; IPR002885; Pentatricopeptide_rpt.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR NCBIfam; TIGR00756; PPR; 1.
DR PANTHER; PTHR12296:SF16; C-MYC PROMOTER-BINDING PROTEIN; 1.
DR PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF13041; PPR_2; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS51498; MABP; 1.
DR PROSITE; PS51375; PPR; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 42..200
FT /note="MABP"
FT /evidence="ECO:0000259|PROSITE:PS51498"
FT DOMAIN 192..642
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REPEAT 810..844
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REGION 894..1000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1227..1250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1262..1346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1433..1484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 911..933
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..955
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 972..986
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1228..1250
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1262..1279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1296..1310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1313..1327
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1328..1346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1436..1484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1924 AA; 215763 MW; 00AEB37031317233 CRC64;
MMEDKGLRVA DYFVVAGLTD ASKPLEEEIH FNDICHKIAK PKAPITDVAI VIKSLGEEVP
QGYTCVETTP TKLSADLNNG SLMGPQIHLC YKRGRDKPPL TDLGVLYEWR ERLKQGCQII
QTTPYGRPAN ISGGTSSQRI YITYRRAPEN MSQNSLALTD ICIIIPSKGE TPPHTFCKVD
KNLNSSMWGS AVFLCYKKSV AKTNTISYKA GLICRYPKED YESFPLPESV PLFCLPMGAT
IECWPSNTKY PLPVFSTFVL TGASGEKVYG AAIQFYEPYF QENLTDKQRS QLGLVSAADR
KPLVSKTVHT NKCICLLSHW PFFDAFKKFL TFLYRYSISG PHVLPIEKHI SHFMHKVPFP
SPQRPRILVQ LSPHDNLILS QPVSSPLPLS GGNFTTLLQN LGPENAVTLL VFAVTEHKIL
IHSLRPAVLT SVTEALVSMI FPFHWPCPYI PLCPLALADV LSAPCPFIVG VDSRYFDMYD
PPPDVSCVDL DTNTISQTEE KKNLTWKILP KKACKNLINS LNNLYQQLAE MQQRPREDAL
MELVMNDYDV NSGAELHLIE MEIQEAFLCF MASILKGYRS YLRPITQAPS EKATDASSLF
DLQGFLKSRD RSHQKFYTMM TKTQMFIRFI EECSFVSDKD ASLAFFDDCV DKVDMERPDE
TRLIELDESH RSEHTVFITP PELPPLPDGE EYPLQYSYNG FPVLKLELFD RPESLLNSQN
SRLASKVSCP SSPSPMFRRT KQEIKIAQKI AKKYSSIPQM WSKCLLRHCY GLWFICLPAY
LKVCHSKVRA LRTAYDVLRK MQVKKLNPPD EVCYRVLMQL CGQYGQPVLA VRVLFEMKKA
GVQPNAITYG YYNKAVLEST WPSTNRGGYF LWMKIRNVIL GLAQFKRALK KHSAAPQTPL
SADGSDLDAV SHGSMDSSND TNTVEQAPFS TDLIKVDSTD DRSSTGGQSD LGYNSLSKEE
VRRGDNSAQY GQVEKETKKE SDTSSLSEIE SAKGSGDSIP QLECQESTCT LKPTTSIVRL
NCPFDNEDKV IVDSSGENAA GLLFTSSLDD SYEDGFMQSS SLRKRHKSAV EPGLKQQMAW
AGRNRNLSGD PVMGFMMNRG VDEPDPREIV EKLGADAKIL SSAFQTIRPN TLDIGKTAYN
PKRSSQLNVE RESSDEDTPF EILADKTDSP VIFDLEDLDN EPDPAKPIKK HVPVPCRLHR
SSSSSFALKP VERLDVETGF DPLSLLAAET DRQKEDEDER GISTPSAKRD LAEEIEMYMN
NMSSPLTSRT PSMDLQKSDD GRATSIKGPS VVKASRRSSL PPNSPRAPIL TRSKTYDLKR
EGKSRDRLWS SPSFSPKSTR QECSPETAGT LALMSPTTFN LDTLLTPTFD VLKSSMFSAG
KGVAEKASKW YSKFSVYASS SKDQNVDRAS ISSAGVQDLE SSSLLDEDVC NDGEVAASPQ
GNNTASNAKR IDQSRTSLES PTSSVQSTSS SFPLPDKSDL GSSRCTSNTS IFQNYAMEVL
ISSCSRCRTC ESLVYDEEIM AGWTADDSNL NSTCPFCGSL FLPFLNIEIR DLRGPGRYFL
KSSASVENMQ IPQGVSADTE IRKPVVSPPD PGLFASPKIT VQANFTRNKK NSQQGYTCAR
SIEIPSERRR GNDESSFLSH PVARSVSTYG HIEQEHKGNW RHHHAVPTGS LPTSFSESID
PLGFNWRLPS PESITVPYLS PLVVWKELES LLENEGDHGI TVADFVDHHP IVFWNLVWYF
RRLDLPSNLP GLILSSEHCN KNSKIPRNWM SEDSKYVLVQ MLWDNLKLHR DPGQPFYILW
NTQTQKSPMV HLRQENDGAF NREFLQNMVK SIQMNDVYKP MSHILEIMSK RPSLKRQRSL
YREILFLSLV ALGKDSIDID AFDREYKMAY DRLTSNQVKL TQNCDRPPST GVMECRKTFG
EPYL
//
