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Database: UniProt
Entry: H3AXP9_LATCH
LinkDB: H3AXP9_LATCH
Original site: H3AXP9_LATCH 
ID   H3AXP9_LATCH            Unreviewed;      1027 AA.
AC   H3AXP9;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   08-MAY-2019, entry version 53.
DE   SubName: Full=ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 {ECO:0000313|Ensembl:ENSLACP00000014420};
GN   Name=ARAP1 {ECO:0000313|Ensembl:ENSLACP00000014420};
OS   Latimeria chalumnae (Coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000014420, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Ensembl:ENSLACP00000014420}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000014420};
RX   PubMed=9215903;
RA   Zardoya R., Meyer A.;
RT   "The complete DNA sequence of the mitochondrial genome of a 'living
RT   fossil,' the coelacanth (Latimeria chalumnae).";
RL   Genetics 146:995-1010(1997).
RN   [2] {ECO:0000313|Proteomes:UP000008672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT   "The draft genome of Latimeria chalumnae.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSLACP00000014420}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AFYH01127295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01127296; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01127297; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01127298; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01127299; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01127300; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01127301; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01127302; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01127303; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01127304; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7897.ENSLACP00000014420; -.
DR   Ensembl; ENSLACT00000014520; ENSLACP00000014420; ENSLACG00000012690.
DR   eggNOG; KOG1117; Eukaryota.
DR   eggNOG; COG5347; LUCA.
DR   GeneTree; ENSGT00940000157424; -.
DR   InParanoid; H3AXP9; -.
DR   OMA; WVKSIAK; -.
DR   TreeFam; TF105769; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd04385; RhoGAP_ARAP; 1.
DR   Gene3D; 1.10.555.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 3.
DR   Gene3D; 3.30.40.160; -; 1.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR037858; RhoGAP_ARAP.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   Pfam; PF01412; ArfGap; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00233; PH; 4.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF57863; SSF57863; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 3.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008672};
KW   GTPase activation {ECO:0000256|SAAS:SAAS01175775};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|SAAS:SAAS01005981};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|SAAS:SAAS01005948};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT   TRANSMEM    405    423       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    444    461       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        3     95       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN      117    206       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN      212    325       Arf-GAP. {ECO:0000259|PROSITE:PS50115}.
FT   DOMAIN      491    524       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN      635    812       Rho-GAP. {ECO:0000259|PROSITE:PS50238}.
FT   DOMAIN      843    934       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
SQ   SEQUENCE   1027 AA;  117482 MW;  43212A2CEF444C48 CRC64;
     LSPVIKDGWL DKNPPQGSYI YQKRWVKLDS DYLRYFDSEK DMYSKRFITL SSISRVAYIG
     DQKFEVITHN RNFLFRADSD TDRNEWVRTL QHVMEDRRSR ASSRLSASPL QGSSSDCVDK
     CGYLELKGCK PKLYVVVMGD KVLLYKNHED FRLGIGITFI EMNLGNVKDV DKKAFDLTTP
     YRTFNFLADS DCEKDEWVEA MQQSIAEALS NSEVAKLIWE EESNTLCADC GAPKPDWASI
     NLCVVICKRC AGKPSFTAPV SKRSDGKSSK FILNSTPVKS CLQIGNARAN TFWAANVPPS
     EAINVTSGTG ERQRFILAKY KEGKYRRYHP LFGNTDELNK FIGVATRSSE TRTSSTGLGN
     GWGVVTFSGN CNYLLSLLKI VPERLWLTET ERGRAHQVSM MKRQLYYTLF LIDFPLICHL
     VFWKLSCYYY IQYSLGKSSF KQRVCILSLG GQGLILIWIL QAPCSQPGRL NSVMLLCVST
     PTPEKKKFEC TFEIYTDSER LYLFGSDSAE TVKEWVKSIA KSFLPPSAED LLNHDFERIG
     RLPYKDGLSL ESTKAGWFAL AKSTLYACFE ESGKEEEIHL KKLLELSVQT DNDVLVLVER
     ARTLFVHGEK KLYFSGWISG IQRASGSSGH MLSEQQLTEA DVPVIVDRCI DYITQCGLTS
     EGIYRKSGQN SKTTNLLETF RKDARRVKLK EGDHHVDDVS NTLKRFFRDI KEGIFTSEAY
     RDWLNTTTGI EDEYQRILQY QQLLTNLPKV NKATLTTLIN HLYCVQRFSE MNQMNTHNLA
     IVFGPTLFQT DGQDHKAGRV IEDLISHYVV IFSVDEQQLK KRLDEISAII KLRIAGSSSG
     PQKGTHCVIS IPLPPQPHTL PLSLQVPASM TAEELTFDIL DRRKVVTRDK DYWCCFEVNM
     REEMERLLHF SEKVLPIFHS LGSDSYLVVK RHLSMEPMLI YLASKVEDTK HGMMKYREDR
     SLLGRNTGSF HDRYFILNST SLRLYKEVRQ KSPCSGSPET SHRPEKEWPV KSLRIYWGIK
     KRLRPPT
//
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