ID H3AY04_LATCH Unreviewed; 743 AA.
AC H3AY04;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN Name=EPHA5 {ECO:0000313|Ensembl:ENSLACP00000014525.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000014525.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000014525.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AFYH01113788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01113789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01113790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01113791; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01113792; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01113793; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01113794; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01113795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01113796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01113797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3AY04; -.
DR STRING; 7897.ENSLACP00000014525; -.
DR Ensembl; ENSLACT00000014625.1; ENSLACP00000014525.1; ENSLACG00000012783.1.
DR eggNOG; KOG0196; Eukaryota.
DR GeneTree; ENSGT00940000156266; -.
DR HOGENOM; CLU_000288_141_4_1; -.
DR InParanoid; H3AY04; -.
DR OMA; VAWTWTW; -.
DR TreeFam; TF315363; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd00063; FN3; 2.
DR CDD; cd05066; PTKc_EphR_A; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR027936; Eph_TM.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR46877; EPH RECEPTOR A5; 1.
DR PANTHER; PTHR46877:SF13; EPHRIN TYPE-A RECEPTOR 5; 1.
DR Pfam; PF14575; EphA2_TM; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF00536; SAM_1; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 270..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 53..163
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 164..259
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 381..642
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 671..735
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
SQ SEQUENCE 743 AA; 82921 MW; 9D20A6ADF93A0596 CRC64;
CRPGFFKASP QSEACSKCPP HSYTLEEAST SCHCEESYYR KDNDPPTMAC TRPPSAPRNA
ISNVNETSVF LEWIPPADTG GRKDVSYNIV CKKCRSDSSL CEECGSHVRY LPQVAALKNT
SVMVVDLLAH TNYTFEIEAV NGVSALSPTP RQFVSVNVTT NQAAPSPISV VKKGKPAKNS
ISLSWHEPDR PNGIILEYEI KYFEKEDQET SYTIIKSKDT EVIADGLKPA SAYIFQIRAR
TAAGYGGFSR RFEFETSPIS VAASNDQSQV PIIAVSVTVG VILLAVVVGF LLSGRRGSPS
PIYIITGLDI PNNTYYFDLI SRRRCGYSKA KQDPEEEKMH FHNGHIKLPG VRTYIDPHTY
EDPNQAVHEF AKEIDASCIT IERVIGAEKG EFGEVCSGRL KLHGKREFPV AIKTLKAGYT
EKQRRDFLGE ASIMGQFDHP NIIHLEGVVT KSKPVMIVTE YMENGSLDTF LKKNDGQFTM
IQLVGMLRGI ASGMRHLSDM GYVHRDLAAR NILVNSNLVC KVSDFGLSRV LEDDPEAAYT
TRGGKIPIRW TAPEAIAFRK FTSASDVWSY GIVMWEVMSY GERPYWEMTN QDVIKAVEEG
YRLPSPMDCP AALYQLMLDC WQKDRNSRPK FEEIVSMLDK LIRNPSSLKT LVNASNRVSN
LLVEHSTVGT NHYRSVGEWL EAIKMGRYTE TFMESGYTSM EAVTQITIED LRLVGVTLAG
HQKKIMNSIQ EIRVQLVNGT VPV
//
