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Database: UniProt
Entry: H3AYY5_LATCH
LinkDB: H3AYY5_LATCH
Original site: H3AYY5_LATCH 
ID   H3AYY5_LATCH            Unreviewed;       485 AA.
AC   H3AYY5;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   24-JAN-2024, entry version 55.
DE   RecName: Full=transketolase {ECO:0000256|ARBA:ARBA00013152};
DE            EC=2.2.1.1 {ECO:0000256|ARBA:ARBA00013152};
GN   Name=TKTL2 {ECO:0000313|Ensembl:ENSLACP00000014856.1};
OS   Latimeria chalumnae (Coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000014856.1, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Proteomes:UP000008672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT   "The draft genome of Latimeria chalumnae.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000014856.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- COFACTOR:
CC       Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC         Evidence={ECO:0000256|ARBA:ARBA00001941};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
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DR   EMBL; AFYH01146001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01146002; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01146003; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H3AYY5; -.
DR   STRING; 7897.ENSLACP00000014856; -.
DR   Ensembl; ENSLACT00000014960.1; ENSLACP00000014856.1; ENSLACG00000013076.1.
DR   eggNOG; KOG0523; Eukaryota.
DR   GeneTree; ENSGT00940000161969; -.
DR   HOGENOM; CLU_009227_3_0_1; -.
DR   InParanoid; H3AYY5; -.
DR   OMA; CKAFHCA; -.
DR   TreeFam; TF313097; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   Bgee; ENSLACG00000013076; Expressed in pelvic fin and 2 other cell types or tissues.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   CDD; cd07033; TPP_PYR_DXS_TK_like; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR020826; Transketolase_BS.
DR   InterPro; IPR033248; Transketolase_C.
DR   InterPro; IPR005474; Transketolase_N.
DR   PANTHER; PTHR43195; TRANSKETOLASE; 1.
DR   PANTHER; PTHR43195:SF4; TRANSKETOLASE-LIKE PROTEIN 2; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF02780; Transketolase_C; 1.
DR   Pfam; PF00456; Transketolase_N; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
DR   PROSITE; PS00802; TRANSKETOLASE_2; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          178..342
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   485 AA;  52689 MW;  933C0E2EF984A965 CRC64;
     FFFTSSFRVF CLLGDGESSE GAVWEAMAFA SYYKLDNLVA IFDVNRLGQS EAAPLQHKTE
     IYRKRCEAFG WNTYVHDGHS VEELCKAFWE AAQVKDRPTA IIAKTFKGKG IPDVEDKDNW
     HGKPIPKDKV ESVLGTIQGR IKSSKLLCPE LPAEDAPQVD ITGIKMPSPP AYKLGSKIAT
     RKAYGVALAK LGQSCSRLVA LDGDTKNSTF SDHFKKEFPD RFIECFIAEQ NMVSVAMGCA
     TRDRTVVFVS TFAAFLSRAY DQIRMGAISQ SNINLSGSHC GVSIGEDGPS QMALEDLAMF
     RAIPTCTVFY PSDGVSTEHA VELAANTKGI CFIRTSRPET PVIYPAEEKF EVGQAKVIRQ
     SKTDRVTVIG AGVTLHEALT AAEELAKEGI NIRVIDPFTI KPLDRATILA SARATGGHVI
     TVEDHYREGG IGEAVSAALA EKPKITVHRL AVSGIPRSGK PTELLDLFGI SAKCIIAAVK
     STFAN
//
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