ID H3AYY5_LATCH Unreviewed; 485 AA.
AC H3AYY5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=transketolase {ECO:0000256|ARBA:ARBA00013152};
DE EC=2.2.1.1 {ECO:0000256|ARBA:ARBA00013152};
GN Name=TKTL2 {ECO:0000313|Ensembl:ENSLACP00000014856.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000014856.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000014856.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- COFACTOR:
CC Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC Evidence={ECO:0000256|ARBA:ARBA00001941};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
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DR EMBL; AFYH01146001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01146002; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01146003; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3AYY5; -.
DR STRING; 7897.ENSLACP00000014856; -.
DR Ensembl; ENSLACT00000014960.1; ENSLACP00000014856.1; ENSLACG00000013076.1.
DR eggNOG; KOG0523; Eukaryota.
DR GeneTree; ENSGT00940000161969; -.
DR HOGENOM; CLU_009227_3_0_1; -.
DR InParanoid; H3AYY5; -.
DR OMA; CKAFHCA; -.
DR TreeFam; TF313097; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000013076; Expressed in pelvic fin and 2 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd07033; TPP_PYR_DXS_TK_like; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR InterPro; IPR020826; Transketolase_BS.
DR InterPro; IPR033248; Transketolase_C.
DR InterPro; IPR005474; Transketolase_N.
DR PANTHER; PTHR43195; TRANSKETOLASE; 1.
DR PANTHER; PTHR43195:SF4; TRANSKETOLASE-LIKE PROTEIN 2; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR Pfam; PF02780; Transketolase_C; 1.
DR Pfam; PF00456; Transketolase_N; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
DR PROSITE; PS00802; TRANSKETOLASE_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 178..342
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 485 AA; 52689 MW; 933C0E2EF984A965 CRC64;
FFFTSSFRVF CLLGDGESSE GAVWEAMAFA SYYKLDNLVA IFDVNRLGQS EAAPLQHKTE
IYRKRCEAFG WNTYVHDGHS VEELCKAFWE AAQVKDRPTA IIAKTFKGKG IPDVEDKDNW
HGKPIPKDKV ESVLGTIQGR IKSSKLLCPE LPAEDAPQVD ITGIKMPSPP AYKLGSKIAT
RKAYGVALAK LGQSCSRLVA LDGDTKNSTF SDHFKKEFPD RFIECFIAEQ NMVSVAMGCA
TRDRTVVFVS TFAAFLSRAY DQIRMGAISQ SNINLSGSHC GVSIGEDGPS QMALEDLAMF
RAIPTCTVFY PSDGVSTEHA VELAANTKGI CFIRTSRPET PVIYPAEEKF EVGQAKVIRQ
SKTDRVTVIG AGVTLHEALT AAEELAKEGI NIRVIDPFTI KPLDRATILA SARATGGHVI
TVEDHYREGG IGEAVSAALA EKPKITVHRL AVSGIPRSGK PTELLDLFGI SAKCIIAAVK
STFAN
//