ID H3AZ51_LATCH Unreviewed; 1029 AA.
AC H3AZ51;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=FERM domain containing 4B {ECO:0000313|Ensembl:ENSLACP00000014922.1};
GN Name=FRMD4B {ECO:0000313|Ensembl:ENSLACP00000014922.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000014922.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000014922.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01063509; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01063510; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01063511; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01063512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01063513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3AZ51; -.
DR STRING; 7897.ENSLACP00000014922; -.
DR Ensembl; ENSLACT00000015026.1; ENSLACP00000014922.1; ENSLACG00000013132.1.
DR eggNOG; KOG3529; Eukaryota.
DR GeneTree; ENSGT01020000230354; -.
DR HOGENOM; CLU_003623_2_0_1; -.
DR InParanoid; H3AZ51; -.
DR OMA; RAPHNPY; -.
DR TreeFam; TF328984; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000013132; Expressed in pelvic fin and 4 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0090162; P:establishment of epithelial cell polarity; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13191; FERM_C_FRMD4A_FRMD4B; 1.
DR CDD; cd17200; FERM_F1_FRMD4B; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR021774; CUPID.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR047176; FRMD4A/B.
DR InterPro; IPR041785; FRMD4A/B_FERM_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46079; FERM DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR46079:SF1; FERM DOMAIN-CONTAINING PROTEIN 4B; 1.
DR Pfam; PF11819; CUPID; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 59..361
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 583..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 724..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 531..558
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 602..671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1029 AA; 118054 MW; 4EEE9B12CDA16719 CRC64;
MASAFMCGVE DLLFNGSRFV WNFTITTLRR WYTDRLRACQ EILRTWCGLR DVYQMTEGRH
CQVILLDDRK LELLVQPKLL SRELLDLVAS HFNLKEKEYF GIKYTDDIGQ SNWLQLDHRV
LDHDLPKKSG PVTMYFAVRF YIESIAFLKD NTTVELFFLN AKSCTYKGEI EIESETLFKL
AAYVLQEAKG DYTSDENART DLKKLPALPT KVLKEHPSLA YCEDRVIDQY KKLKNLTRGQ
TIVKYMTQVE ALLTYGVHYY EVKDKQEIPW WLGISYKGIG QYDLQDKVKP RKFFQWKQLE
NLYFREKKFA VEVNDPRRVP LSRRTFGHSG LVVNTWYASP SLIKSIWVMA ISQHQFYLDR
KQSKAKIPSA RSLGDIAMDL TDTGAPKNFK LTASVSKNQP IMASNGSLIS AGSQDSEVSE
EQRKEKIIAL RKKEKALQET LAQKLEELKK ICLREAELTG KLPEEYPLGP DEKPPQLRRR
VGTAFKLDDD FLQNEEDPTL QNLESSFVIQ QKVVEAERKL ATEPDISKNV KRRRKQDYAD
ALKKLQDLEN AINEHRIKYG KKPTQRASLL VAVSLDDLIQ SESSSLSDTT TVDDDDSREA
TQQRCTSVQH SPRPHPPQSL GIEQNQQRKT STSELIYNKG PARDSLSTHS SPYRTQGRQH
HGGKSVPTTP VLTRNAYSSS HLQSHALSQH QRQRSGSLES EASLLCELPN EKQLLAFSRI
QRSNSTEVLD DRSSTSQSST EYYSNQPNQQ YAAQTIDYRT RDRRRYKRYI SAANSGSMPN
LAHKDIRNGV YQNSQNQPPP SFYVRGYSPY PDHEVYYNGG YVYENGTEGH YPVNPSNRVT
YYGHDHYREH GHCYGDEVDS LSQNVYATLR PSKRTVARTE QKHFKDEMVS QELRWWYKRA
TSQKDLSQNL QAGFDPERGS QKNLSFPGSQ APFSPTSRAT SFSSKILVSS AASTGTWRSQ
VNVGLPEYDT MGHPYNSGYG NVYSNTLPQN RYVEYSETNV LDSSQLENSL PTDEQVLYWH
EDPKPGTLV
//
