ID H3AZK4_LATCH Unreviewed; 537 AA.
AC H3AZK4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Heat shock transcription factor 1 {ECO:0000313|Ensembl:ENSLACP00000015075.2};
GN Name=HSF1 {ECO:0000313|Ensembl:ENSLACP00000015075.2};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000015075.2, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000015075.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HSF family. {ECO:0000256|ARBA:ARBA00006403,
CC ECO:0000256|RuleBase:RU004020}.
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DR EMBL; AFYH01076810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01076811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01076812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01076813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01076814; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01076815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01076816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01076817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01076818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_014344337.1; XM_014488851.1.
DR AlphaFoldDB; H3AZK4; -.
DR STRING; 7897.ENSLACP00000015075; -.
DR Ensembl; ENSLACT00000015181.2; ENSLACP00000015075.2; ENSLACG00000013265.2.
DR GeneID; 102350885; -.
DR CTD; 3297; -.
DR eggNOG; KOG0627; Eukaryota.
DR GeneTree; ENSGT00940000158421; -.
DR InParanoid; H3AZK4; -.
DR OMA; MPIFFEL; -.
DR OrthoDB; 1117127at2759; -.
DR TreeFam; TF330401; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000013265; Expressed in chordate pharynx and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000232; HSF_DNA-bd.
DR InterPro; IPR027725; HSF_fam.
DR InterPro; IPR010542; Vert_HSTF_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10015:SF274; HEAT SHOCK FACTOR PROTEIN 1; 1.
DR PANTHER; PTHR10015; HEAT SHOCK TRANSCRIPTION FACTOR; 1.
DR Pfam; PF00447; HSF_DNA-bind; 1.
DR Pfam; PF06546; Vert_HS_TF; 1.
DR PRINTS; PR00056; HSFDOMAIN.
DR SMART; SM00415; HSF; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00434; HSF_DOMAIN; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 51..75
FT /note="HSF-type DNA-binding"
FT /evidence="ECO:0000259|PROSITE:PS00434"
FT REGION 267..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 537 AA; 59108 MW; F269FD1CF25AE2B2 CRC64;
MDLHGGGNVP AFLTKLWTLV EDPDTDPLIC WSPSGNSFHV FDQGQFAKEV LPKYFKHNNM
ASFVRQLNMY GFRKVVHIEQ GGLVKPEKDD TEFQHPYFIR GQEHLLENIK RKVTSVSGLK
SDDIKIRQDN MSKLLTDVQL MRGKQENIDS KLLAMKHENE ALWREVASLR QKHSQQQKVV
NKLIQFLISL VQSNRIIGVK RKIPLMLNDS SSAHSMPKYS RQYSLEHLHG PATFTASSPP
YTGTKLYSSD SAENLGPIIS DVTDLAQSSP CVSPSASTRE ERSSPVIRIK EEPPSPAHSP
QIEEVSVIDT GTESCLSPST FIDSILQENE TSGSSNASTS IDPSTAQSQP EERCLSVACL
DSLVQSPQMS EVARLFPSPS TSSLHCRPQQ GNDLCDHLDT IDSNLDNLQT MLSAQSFSMD
TSTLFDLFNP SLPTSDMGLP DLDTSLDTIQ DLLSSQEQKP TDTDSNTADT GKQLVHYSAQ
PLFLLDSGSG DMGSGDLPIL FELGDAPYFA EGDESEDPTI ALLSSTDESK PKDPAIS
//
