ID H3B0H4_LATCH Unreviewed; 605 AA.
AC H3B0H4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Potassium voltage-gated channel subfamily Q member 4 {ECO:0000313|Ensembl:ENSLACP00000015395.1};
GN Name=KCNQ4 {ECO:0000313|Ensembl:ENSLACP00000015395.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000015395.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000015395.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AFYH01081926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01081927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01081928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01081929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01081930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3B0H4; -.
DR STRING; 7897.ENSLACP00000015395; -.
DR Ensembl; ENSLACT00000015501.1; ENSLACP00000015395.1; ENSLACG00000013552.1.
DR eggNOG; KOG1419; Eukaryota.
DR GeneTree; ENSGT00940000159209; -.
DR HOGENOM; CLU_011722_8_3_1; -.
DR InParanoid; H3B0H4; -.
DR OMA; YATCLHM; -.
DR TreeFam; TF315186; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR PANTHER; PTHR47735:SF7; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF03520; KCNQ_channel; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..605
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003579689"
FT TRANSMEM 37..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..234
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 366..554
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
SQ SEQUENCE 605 AA; 68792 MW; B13B4CCDCBB8C318 CRC64;
MYLFIYLFFR FVLVFSCLVL SVFSTIAEHQ DVANEGLFIL EFVMIVVFGL EYAIRVWSAG
CCCRYRGWQG RLRFARKPFC VIADFIVFVA SLAVIAAGTQ GNVFATSALR SMRFLQILRM
VRMDRRGGTW KLLGSVVYAH SKELITAWYI GFLVLIFSSF LVYLAEKDHN DQFSTYADSL
WWGTITLTTI GYGDKTPETW LGRVLAAGFA LLGISFFALP AGILGSGFAL KVQEQHRQKH
FEKRRTPAAN LIQAAWRLYS TDVQRSYLTA TWNYYDSVLP SFRELVLLFE PLHRSRNGAV
RNCEMKKTLE EPSRSHSFLS VSRCNVSPYM SGESGKLGLK DRIRMNNTRV QGVRSKQQLT
PSVRCSPSTE NVNETISPTK VQKSWSFNDR TRFRTSLKLK PRLPIEGHAD GHGEDSNDEK
AYHCDLTVED IMPAVKTLIR SVRILKFLVA KRKFKETLRP YDVKDVIEQY SAGHLDMLGR
IKSLQIRVDQ IIGRGPIPND KKTREKGEKV PPELDQMDEL SMMGRVVKVE KQVQSIEQKL
DLLLDVYSQC LRKGSDSSFT LVTNMQLPLI DHDLTSDYHS PVGHADISMS AQTLNISRSA
STNMD
//
