ID H3B0Q6_LATCH Unreviewed; 595 AA.
AC H3B0Q6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Phosphoinositide-3-kinase regulatory subunit 1 {ECO:0000313|Ensembl:ENSLACP00000015477.1};
GN Name=PIK3R1 {ECO:0000313|Ensembl:ENSLACP00000015477.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000015477.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000015477.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3K p85 subunit family.
CC {ECO:0000256|ARBA:ARBA00009442}.
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DR EMBL; AFYH01107851; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01107852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01107853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01107854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01107855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01107856; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01107857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01107858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01107859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01107860; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006000155.1; XM_006000093.2.
DR AlphaFoldDB; H3B0Q6; -.
DR Ensembl; ENSLACT00000015584.1; ENSLACP00000015477.1; ENSLACG00000013626.2.
DR GeneID; 102353218; -.
DR CTD; 5295; -.
DR GeneTree; ENSGT00940000155553; -.
DR HOGENOM; CLU_007031_1_0_1; -.
DR OrthoDB; 2880119at2759; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000013626; Expressed in post-anal tail muscle and 6 other cell types or tissues.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd12924; iSH2_PIK3R1; 1.
DR CDD; cd04388; RhoGAP_p85; 1.
DR CDD; cd09930; SH2_cSH2_p85_like; 1.
DR CDD; cd09942; SH2_nSH2_p85_like; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR InterPro; IPR044124; ISH2_PIK3R1.
DR InterPro; IPR032498; PI3K_P85_iSH2.
DR InterPro; IPR035020; PI3kinase_P85_cSH2.
DR InterPro; IPR035022; PI3kinase_P85_nSH2.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR Pfam; PF16454; PI3K_P85_iSH2; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00017; SH2; 2.
DR PRINTS; PR00678; PI3KINASEP85.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00252; SH2; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50001; SH2; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 1..172
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 204..299
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 495..589
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT COILED 320..347
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 385..433
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 595 AA; 69005 MW; 6EF9DBD735F735C3 CRC64;
MLTKLVEAIE RRGLECATLY RTPASSSGAE LRQSLESDAA LVDVEQFDVS ALSDALRRYL
QDLPNPIIPA SVCSEMVYVA QEAQNPDECT QLLKKIIRSP NVPQQNLLTL QYLIKHFFKL
CQNSNKNLLT PRVLAEIFSP LLFRHQAASL DTNPEYHTKI IEALITSEWN ERQAAPALPP
KPPKPTPVAN NGMNNNMSLQ EAEWYWGDIS REEVNEKLRD TADGTFLVRD ASTKMLGDYT
LTLRKGGNNK LIKIFHRDGK YGFSDPLTFN SVIELINHYH HESLAQYNPK LDVKLLYPVS
KYQQDQVVKE DNIDAVGKKL HEYNIQYQDK SREYDRLYEE YTRTSQEIQM KRTAIEAFNE
TIKIFEEQCQ TQERYCKEYI EKFKREGNEK EIQRIMVNYE KLKSRISEIV DSKRRLEEDL
KKQAADYREI DKRMNSIKPD LIQLRKTRDQ YLLWLTQKGV RQKKLNEWLG NESTEDQYSM
VEDDEDLPHH DERTWNVGNI NRNQAESLLR GKRDGTFLVR ESSKPGCYAC SVVVDGEVKH
CVINKTPTGY GFAEPYNLYG SLKELVLHYQ HTSLVQHNDS LNVTLAIPVN AQQRR
//