ID H3B1G7_LATCH Unreviewed; 488 AA.
AC H3B1G7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=tRNA dimethylallyltransferase {ECO:0000256|PIRNR:PIRNR039110};
DE EC=2.5.1.75 {ECO:0000256|PIRNR:PIRNR039110};
GN Name=TRIT1 {ECO:0000313|Ensembl:ENSLACP00000015738.2};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000015738.2, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000015738.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the transfer of a dimethylallyl group onto the
CC adenine at position 37. {ECO:0000256|PIRNR:PIRNR039110}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=adenosine(37) in tRNA + dimethylallyl diphosphate =
CC diphosphate + N(6)-dimethylallyladenosine(37) in tRNA;
CC Xref=Rhea:RHEA:26482, Rhea:RHEA-COMP:10162, Rhea:RHEA-COMP:10375,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57623, ChEBI:CHEBI:74411,
CC ChEBI:CHEBI:74415; EC=2.5.1.75;
CC Evidence={ECO:0000256|PIRNR:PIRNR039110};
CC -!- SIMILARITY: Belongs to the IPP transferase family.
CC {ECO:0000256|ARBA:ARBA00005842, ECO:0000256|PIRNR:PIRNR039110,
CC ECO:0000256|RuleBase:RU003785}.
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DR EMBL; AFYH01052431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01052432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01052433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01052434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_014342668.1; XM_014487182.1.
DR AlphaFoldDB; H3B1G7; -.
DR STRING; 7897.ENSLACP00000015738; -.
DR Ensembl; ENSLACT00000015848.2; ENSLACP00000015738.2; ENSLACG00000013861.2.
DR GeneID; 102360123; -.
DR KEGG; lcm:102360123; -.
DR CTD; 54802; -.
DR eggNOG; KOG1384; Eukaryota.
DR GeneTree; ENSGT00390000015214; -.
DR HOGENOM; CLU_032616_2_1_1; -.
DR InParanoid; H3B1G7; -.
DR OMA; WGLHLKS; -.
DR OrthoDB; 11270at2759; -.
DR TreeFam; TF315069; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000013861; Expressed in chordate pharynx and 4 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0052381; F:tRNA dimethylallyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 1.10.20.140; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00185; IPP_trans; 1.
DR InterPro; IPR039657; Dimethylallyltransferase.
DR InterPro; IPR030666; IPP_transferase_euk.
DR InterPro; IPR018022; IPT.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR022755; Znf_C2H2_jaz.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR NCBIfam; TIGR00174; miaA; 1.
DR PANTHER; PTHR11088; TRNA DIMETHYLALLYLTRANSFERASE; 1.
DR PANTHER; PTHR11088:SF95; TRNA DIMETHYLALLYLTRANSFERASE; 1.
DR Pfam; PF01715; IPPT; 1.
DR Pfam; PF12171; zf-C2H2_jaz; 1.
DR PIRSF; PIRSF039110; IPP_transferase; 1.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR039110};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR039110};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR039110};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR039110};
KW tRNA processing {ECO:0000256|PIRNR:PIRNR039110};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 424..446
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS00028"
FT REGION 443..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..478
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 488 AA; 55795 MW; 41D9716A5A923AE8 CRC64;
MCGTTQSRIL HYYGNRHAFS HQATLCCSRM AAACQRVRSS LPLLVILGAT GTGKSKLAIE
LGQRLGGEII SADSMQIYKG LDIITNKVTP EEQQLCKHHM ISIVDPLVST YTVVEFRNKA
LSLIEDIFGR KKIPIVVGGT NYYIESLLWK VLIDQKERNI SPSETWEDTV KASPPNLKKE
LETLDSQELH RRLREVDPEM AARLHPHDKR KVARSLQVYE ETGIPHSKLI HQQQQADGGG
PLGGPLRFQD PCILWLNADL AALDKRLDQR VDDMLDAGLL DELKDFHDRY NQEKVVNKSQ
DYEHGIFQSI GFKEFHEYLT MGDHFTEEDR QKLLKKGIEA LKQATKRYAR KQNKWVRNRF
LKRPGVSVLP VYGLDVTDVA QWKESVLKPA LHIVESFMKG EKPALEPVKV DYDKNENKRS
HHVCELCDKI ILGDREWTAH LKSKSHLHHT RKRRKLEAKE CPAEQKRDAQ RAEATRENPD
GADTLTTV
//
