UniProt: H3B1J1

Database: UniProt
Entry: H3B1J1_LATCH

LinkDB:  H3B1J1_LATCH 
Original site:  H3B1J1_LATCH

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Ontology (2)   
   GO (2)   
Gene (5)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (8)   
   InterPro (6)   
   Pfam (2)   
All databases (17)   

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ID   H3B1J1_LATCH            Unreviewed;       378 AA.
AC   H3B1J1;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 66.
DE   SubName: Full=Potassium inwardly rectifying channel subfamily J member 10 {ECO:0000313|Ensembl:ENSLACP00000015762.1};
GN   Name=KCNJ10 {ECO:0000313|Ensembl:ENSLACP00000015762.1};
OS   Latimeria chalumnae (Coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000015762.1, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Proteomes:UP000008672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT   "The draft genome of Latimeria chalumnae.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000015762.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU003822}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel (TC
CC       1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}.
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DR   EMBL; AFYH01101365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005999398.1; XM_005999336.1.
DR   AlphaFoldDB; H3B1J1; -.
DR   STRING; 7897.ENSLACP00000015762; -.
DR   Ensembl; ENSLACT00000015872.1; ENSLACP00000015762.1; ENSLACG00000013883.1.
DR   GeneID; 102358335; -.
DR   KEGG; lcm:102358335; -.
DR   CTD; 3766; -.
DR   eggNOG; KOG3827; Eukaryota.
DR   GeneTree; ENSGT00990000203615; -.
DR   HOGENOM; CLU_022738_3_3_1; -.
DR   InParanoid; H3B1J1; -.
DR   OMA; QVNVAFQ; -.
DR   OrthoDB; 4126787at2759; -.
DR   TreeFam; TF313676; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 2.60.40.1400; G protein-activated inward rectifier potassium channel 1; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003269; K_chnl_inward-rec_Kir1.2.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767:SF21; ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 10; 1.
DR   PANTHER; PTHR11767; INWARD RECTIFIER POTASSIUM CHANNEL; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01322; KIR12CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU003822};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU003822};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|ARBA:ARBA00022958, ECO:0000256|RuleBase:RU003822};
KW   Potassium transport {ECO:0000256|ARBA:ARBA00022538,
KW   ECO:0000256|RuleBase:RU003822};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003822};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003822};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW   ECO:0000256|RuleBase:RU003822}.
FT   TRANSMEM        68..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        142..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          31..172
FT                   /note="Potassium channel inwardly rectifying transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF01007"
FT   DOMAIN          179..346
FT                   /note="Inward rectifier potassium channel C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17655"
FT   SITE            158
FT                   /note="Role in the control of polyamine-mediated channel
FT                   gating and in the blocking by intracellular magnesium"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005465-1"
SQ   SEQUENCE   378 AA;  42913 MW;  946D51392FB65382 CRC64;
     MTSLDKVFYS QTTQTESRAL IGTTLRKRRV MSKDGHSNVR MDHIADKSFL YLKDLWTTFI
     DMKWRYKLLL FSMTFVGTWF LFGMIWYLIA LVHGDLLEFD PPSNHTPCVM QVHTLTGAFL
     FSLESQTTIG YGFRYISEEC PVAIILLISQ LVLTTIMEIF ITGTFLAKIA RPKKRAGTIK
     FSHNAVVSQQ EGKLCLMIRV ANMRKSLLIG CQVSGKLLQT YVTKEGESIG LNQNNVDFQV
     DTSSDSPFLI LPLTFYHVID SNSPFRDISF SSRDTDFELV VILSGTVEST SATCQVRTSY
     LPEEILWGYE FPPVISISPS GKYVADFSCF DKVVKVHTPH CLHESLKYGD PEKMKLEESY
     RERSEKEGSA LSVRISNV
//

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