ID H3B1Q9_LATCH Unreviewed; 2023 AA.
AC H3B1Q9;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|RuleBase:RU364134};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000015830.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000015830.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
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DR EMBL; AFYH01106476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01106477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01106478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01106479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01106480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01106481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01106482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01106483; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01106484; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01106485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7897.ENSLACP00000015830; -.
DR Ensembl; ENSLACT00000015940.1; ENSLACP00000015830.1; ENSLACG00000013940.1.
DR eggNOG; KOG3600; Eukaryota.
DR GeneTree; ENSGT00390000013680; -.
DR HOGENOM; CLU_000508_0_0_1; -.
DR InParanoid; H3B1Q9; -.
DR OMA; KIPDQCY; -.
DR TreeFam; TF316867; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF1; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13-LIKE; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 1227..1579
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1616..2012
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 271..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 834..905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1336..1474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1860..1900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..323
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 834..848
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 867..905
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1338..1364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1374..1406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1422..1469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1860..1888
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2023 AA; 221942 MW; 6449976615AF2A34 CRC64;
SEHLSCAFTF FLHGDSNVCT SVEIAQHQPL YLVNEEHIAL AQSAASPFQV ILSPYGLSGT
LTGQAYKMSD PATRKLLEEW QYFYPMVLKK KEGVKEEASM EYDDDSPVAV EVIIGGVRMV
YPSAFVLISQ NDIPVSQSVS SAGGQLSFGQ LGLGSIKESN SCGMPLTPPT SPEQANLGEM
GGLQTTVSHL PGQEGAAGLQ SPKRLGKIPQ QMVHRVWKEC NLSKVQPRRT QAANGNPEEE
ACNNVPAWDF VEPAKRVTCS CYRHKLLKQR NAVGPSRPQT TSQPGFNGGG SSSSSSSLPP
PASSKHKTTD KQEKGDKQQK RPMTPFHHRP SVTEELCMEQ DPSGQKLSLA GIDPSLDVHG
SRKFPKQVPE TLQSKPINLN PMDSPHSPGS PLPPTLSPQP RGQEAEVLDP TSVPMNPALF
MQEVSETALY CGAIGSHSQE WWQGFSLPSS EDTGFRTPKL HGDICDLKQE ANTDSSALKR
LLAQPNKRFK ILEERIQAQV ESLNYMDPSR LIQQLGDSSG EASDPYTFVD GDIKYSFTSS
KKYKIGTEKD PMKKAKSEEG FITRETPLPG HPAAVPDGKD AMSIFSPTPK NADARQDGAL
SRTVPTSLMR ETDLVVSLND LDNIFDNSDE DELGEFIKRL FNSCSPVLFV PQGKPTTTVR
PFIFSVADLQ RMFPTPPSLE QHPAFSPVMS YKDGISSETG TGLIVMDNPI INMATAQLAE
YKMEVEDGLG SPKPEEIKDF SYVHKAVTVQ PFIGSSVFAP LKTLPSQCLP PLKALDSCLY
RPSWAIPPKI EHLPLPPAAP FIRDGYVNVP SVGSLADQDY IQMNTPQIST PVAVSSTAPA
SNSGAGVLPS PATPRFSVPT PRTPRTPRTP RGVSTASGQG SVKYDGTDLC SPASTPSTTR
PLNSVEPATV QSIPEAHSLY VTLILSDSVM NIFKDRNFDS CCICACNMNI KGADVGLYIP
DSSNEDQYRC TCGFSAIMNR KLGYNSGLFI EDEMDIFGRG SEMGQAAERR LMMCRTTALP
QTGDGNKRPQ DPPPNLLILL QDQCTRLFTS LSSIDCISSR NRPALPLGTW LYDKLRADGS
DCCTECFNAL EQGRQYVDNP TGGKVDEALV RSTSLHYWPH TNVLDISMLS SQDVVRMLLS
LQPFLQDAIQ KKRTGRTWEN IQHVQGPLTW QQFHKMAGRG SYGSEESPEP LPIPTLLVGY
DKDFLTISPF ALPFWERLLL DPYGGQRDVA YLVVCPENEA MLDEARTFFR DLSAVYEMCR
LGQHRPICKV LRDGIMRVGK NAAQKLSEEP VDEWFSQPWS SEESDNHSKL KLYAQVCRHH
LAPYLATLQL DNGLLIPPKH QPSSNTSSTQ SQAAPGNTGS CPSNPEVAPA PGPTGSGVNS
TSSTGSINGM SSGSISGSSV PPASSTVPGL NLMGVAPPSS GFGGSVGTNP MQNANPTANS
VDRPQGSTPS MGGEAEAGQN SMQQQQEGQE NATDRERIGI PTEAESADSN TYPPAVVIYI
VDPFTYTSDE ESPTANMWLL GLMRCYTEML DNLPENMRNS FILQIVPCQY LLQPVKDDHV
FYSQHLKSLA FSIYSQCRRP LPTQIHIKSL TGFGPAASIE MVLKNPESPS DLEIYRKPYF
LLHIREKQEE FINSFSLCSQ KQQMYKSGVH VECKEEWLSV EFRELWYKCI FVCMHVLHLP
VTVHKHIHTI SKFSCKVTLD WCVHLLQMKG IVWCLNINLK KKLSSKKKKN WSILLGECSL
QSISKQLKET CKMCGISAGD SPSILSACLV AMEPQGSFVV MPDAVTMGSV FGRSTALNMQ
TSQLNTPQDA SCTHILVFPM SATIQVAPAN YPNEDGLSPI NDDMFDLQFD EMDNDIGIFI
TSPNSSPVPS PGSPSGIGGS SHFQHSRSQG ERLSSKEAPE ELKQQPLALG YYVSTAKAEN
LPHWFWSSCP QAQNQCPLFL KASLHHHISI AQTDELLSSK KPQRVPHPLD SKTTSDVLSR
FVLEQYNALS WLMCNPATHD RRSCLPLHFV VLTQMYNAIM NLL
//
