ID H3B1T4_LATCH Unreviewed; 516 AA.
AC H3B1T4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Fibroblast growth factor receptor substrate 3 {ECO:0000313|Ensembl:ENSLACP00000015855.1};
GN Name=FRS3 {ECO:0000313|Ensembl:ENSLACP00000015855.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000015855.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000015855.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01129007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01129008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006002345.1; XM_006002283.2.
DR RefSeq; XP_014347679.1; XM_014492193.1.
DR AlphaFoldDB; H3B1T4; -.
DR STRING; 7897.ENSLACP00000015855; -.
DR Ensembl; ENSLACT00000015965.1; ENSLACP00000015855.1; ENSLACG00000013962.1.
DR GeneID; 102354082; -.
DR KEGG; lcm:102354082; -.
DR CTD; 10817; -.
DR eggNOG; KOG4047; Eukaryota.
DR GeneTree; ENSGT00940000159495; -.
DR HOGENOM; CLU_022374_0_0_1; -.
DR InParanoid; H3B1T4; -.
DR OMA; CQPDRGG; -.
DR OrthoDB; 2996885at2759; -.
DR TreeFam; TF324994; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd01202; PTB_FRS2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR038742; FRS2_PTB.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR21258; DOCKING PROTEIN RELATED; 1.
DR PANTHER; PTHR21258:SF39; FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 3; 1.
DR Pfam; PF02174; IRS; 1.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51064; IRS_PTB; 1.
PE 4: Predicted;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00022707};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Myristate {ECO:0000256|ARBA:ARBA00022707};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 13..115
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 157..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 446..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..379
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 516 AA; 58286 MW; 7C0A756957AD0B9E CRC64;
MGSCWSCCYR DTFLDNHPTK FKVTNVDDEG NELGSGIMEL TQTELILHTQ KRDAVRWPYL
CLRRYGYDSN LFSFESGRRC QTGQGIFAFK CLRAEEIFNL LQELMQCNSI NVVEEPVLMT
RSTHPTELDL PRTPQTPNTP AYTMLGFPNG FPGYPIPGEG SSHSSTRHPS VGSMRHSSVG
EESTHALIGG EDQAHTYVNT ANVDEEMRSR RCLHTLPEVR PSFPESARHH GAHCCSLEER
NPKVFLQPGE VKFVLGPTPA QRRLMEREGL VRFQREHQDC GGHICGSERE TCHNNNDHKE
PCHAGRLTYE NINGLLPPGN AVGLRRGGPA LNNCSYRKTA LLNYENLPAL PPVWECQPLR
REEEEEEEEE YDEEDCEDPM TPSLNSYHHD PDPLRNYVNT ENVTLQPSLH KADFTRRQDC
TPNVFSFDFQ RPHPEPRHLN YIQVELEGGG GGGGGPHNPQ TPRAPCPVPP TPSRHSDFYA
VIDIKRTTAM SSLQRALPRE DGTSRKTRHN STDLPL
//
