ID H3B226_LATCH Unreviewed; 745 AA.
AC H3B226;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Cyclic nucleotide gated channel subunit alpha 2 {ECO:0000313|Ensembl:ENSLACP00000015947.1};
GN Name=CNGA2 {ECO:0000313|Ensembl:ENSLACP00000015947.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000015947.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000015947.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AFYH01119645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01119646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01119647; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3B226; -.
DR STRING; 7897.ENSLACP00000015947; -.
DR Ensembl; ENSLACT00000016057.1; ENSLACP00000015947.1; ENSLACG00000014042.1.
DR eggNOG; KOG0500; Eukaryota.
DR GeneTree; ENSGT00940000155374; -.
DR HOGENOM; CLU_005746_12_0_1; -.
DR InParanoid; H3B226; -.
DR OMA; DWYYHWL; -.
DR TreeFam; TF319048; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.5.300; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR032406; CLZ_dom.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR PANTHER; PTHR45638:SF3; CYCLIC NUCLEOTIDE-GATED OLFACTORY CHANNEL; 1.
DR Pfam; PF16526; CLZ; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Olfaction {ECO:0000256|ARBA:ARBA00022725};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 218..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 357..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 533..647
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 674..719
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 745 AA; 85778 MW; F7A8548EB487D920 CRC64;
MTGQINIQSN STSNHRLSVK TPADEELERI ENNHSRTQSV CDDTSSELQR VATLDNGGLT
SRNSFRGRGA LSRFVRLVVV VRDWAHKSLH EEERRPDSFL ERFRGPELRA VPSQISISRS
GQEDADGKGK NKNWKLPNTN IIFQCLIGHS VFEEKKLQLL PFLITFNQVF ERVQELILFK
DQMHHVKFVK VSLLRRGSYA SIKIKKRSVF VIDPAQDLYY RWLFVVAVPV LYNWCLLVAR
ACFNDLQTEN FILWLVLDYV SDAIYILDTF FRLRTGFLEQ GLLVKDLKRL RDIYIRTLQF
KLDVISILPT DLVYIVVGIH TPELRFNRLL RFPRMFEFFD RTETRTNYPN IFRISNLVLY
ILIIIHWNGC IYFAISKSIG FGTDSWVYPN ISNPEFGYLT REYIYCLYWS TLTLTTIGET
PPPVTDEEYL FVVFDFLAGV LIFATIVGNV GSMISNMNAS RAEFQAKIDS IKHYMQFRKV
SKDMEAKVIR WFDYLWTNKK TVDEREVLKN LPDKLKAEIA INVHLETLKK VRIFQDCEAG
LLVELVLKLR PQVFSPGDYI CRKGDIGKEM YIIKEGKLGV VADDGVTQYA LLTAGGCFGE
ISILNIKGSK MGNRRTANIR SIGYSDLFCL SKEDLMEAVT EYPDAKKVLE ERGKEILVKE
GLLDESAAEV GIGEKDVEEK IERLESNLDT LQTRFARLLT EYTSTQQKLK QRITNLEAKV
KLLNYGYLSD GMDSATDTEG KSENE
//