ID H3B296_LATCH Unreviewed; 380 AA.
AC H3B296;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Catenin alpha-2 {ECO:0000256|ARBA:ARBA00023806};
DE AltName: Full=Alpha N-catenin {ECO:0000256|ARBA:ARBA00029822};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000016017.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000016017.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the vinculin/alpha-catenin family.
CC {ECO:0000256|ARBA:ARBA00008376}.
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DR EMBL; AFYH01091637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01091638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01091639; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01091640; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01091641; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01091642; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01091643; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01091644; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01091645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01091646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3B296; -.
DR STRING; 7897.ENSLACP00000016017; -.
DR Ensembl; ENSLACT00000016128.1; ENSLACP00000016017.1; ENSLACG00000014104.1.
DR eggNOG; KOG3681; Eukaryota.
DR GeneTree; ENSGT01030000234543; -.
DR HOGENOM; CLU_015314_0_0_1; -.
DR InParanoid; H3B296; -.
DR OMA; YAEMENY; -.
DR TreeFam; TF313686; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000014104; Expressed in pelvic fin.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0045296; F:cadherin binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 2.
DR InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR InterPro; IPR001033; Alpha_catenin.
DR InterPro; IPR006077; Vinculin/catenin.
DR PANTHER; PTHR18914; ALPHA CATENIN; 1.
DR PANTHER; PTHR18914:SF23; CATENIN ALPHA-2; 1.
DR Pfam; PF01044; Vinculin; 2.
DR PRINTS; PR00805; ALPHACATENIN.
DR SUPFAM; SSF47220; alpha-catenin/vinculin-like; 2.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT REGION 339..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..358
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 380 AA; 42185 MW; FA77E7FD4E89AF91 CRC64;
LMSQLVMPRF AEQVEVAIEA LSANVPQPFE ENEFIDASRL VYDGVRDIRK AVLMIRTPEE
LEDDSDFEQE DYDVRSRTSV QTEDDQLIAG QSARAIMAQL PQEEKAKIAE QVESFHQEKC
KLDAEVAKWD DSGNDIIVLA KQMCMIMMEM TDFTRGKGPL KNTSDVINAA KKIAEAGSRM
DKLARAVADQ CPDSACKQDL LAYLQRIALY CHQLNICSKV KAEVQNLGGE LIVSGTGVNK
VFTLLYSVID IDIIKGGRIY EGAMEDGTCT ERRPIGMTNA GISVLLDSAT SLIQAAKNLM
NAVVLTVKAS YVASTKYQKV YGTAAVNSPV VSWKMKAPEK KPLVKREKPE DYQTRVRRGS
QKKHISPVQA LSEFKAMDSF
//
