ID H3B2F0_LATCH Unreviewed; 611 AA.
AC H3B2F0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=General transcription and DNA repair factor IIH helicase subunit XPD {ECO:0000256|ARBA:ARBA00014344};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=ERCC2 {ECO:0000313|Ensembl:ENSLACP00000016071.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000016071.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000016071.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the helicase family. RAD3/XPD subfamily.
CC {ECO:0000256|ARBA:ARBA00009146}.
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DR EMBL; AFYH01034957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01034958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01034959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01034960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01034961; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01034962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01034963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01034964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01034965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3B2F0; -.
DR STRING; 7897.ENSLACP00000016071; -.
DR Ensembl; ENSLACT00000016182.1; ENSLACP00000016071.1; ENSLACG00000014155.1.
DR eggNOG; KOG1131; Eukaryota.
DR GeneTree; ENSGT00950000182970; -.
DR HOGENOM; CLU_011312_1_0_1; -.
DR InParanoid; H3B2F0; -.
DR OMA; IREQFFR; -.
DR TreeFam; TF101232; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000014155; Expressed in chordate pharynx and 2 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0061031; P:endodermal digestive tract morphogenesis; IEA:Ensembl.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd17969; DEAHc_XPD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR010643; HBB.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR InterPro; IPR001945; RAD3/XPD.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR PANTHER; PTHR11472:SF1; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF06777; HBB; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR PRINTS; PR00852; XRODRMPGMNTD.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 7..290
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
SQ SEQUENCE 611 AA; 69414 MW; A62AE9A79CE39BB2 CRC64;
LRLNIDGLLV YFPYDYIYPE QYSYMLELKR TLDAKGHGVL EMPSGTGKTV SLLSIIVAYQ
RMYPMEVTKL IYCSRTVPEI EKVIEELRKL LDYYEKQTGE KMMFLGLALS SRKNLCIHPE
VSPPRTGVMI KKKKPPPFYS LLPAFQLCEN VSLYPGCLFL QEFDANGRQV PLPSGVYNLD
DLKTYGKFKG WCPYFLARYT ILHANVVVYS YHYLLDPKIA DLVSKELVKK SVVVFDEAHN
IAGICDRLLA AKVNHVSASL VFGDNCLAVF SVLAVVGIKE TDAAKLKEEY RRLVEGLKEA
NVARETDVYL ANPVLPDEIL QEAVPGNIRT AEHFVGFIKR FLEYLKSRLR VHHMIQESPP
SFLKDIFEKV CIERKPLRFC SERLRCLLRT LEITDIADFS PIVLLANFAT LVSTYGKGFT
IIIEPFEDRT PTIANPVLHF SCMDASIAIK PVFERFQSVI ITSGVRQYKT GEIFLSILLS
IYRVFIKSLC NFKLIVGRGN DQVAISSKFE TREDIAVIRN YGNLLLEMSA IVPDGIVAFF
TSYQYMENIV ASWYEQGILE NIQRNKLIFI ETQDAAETSM ALEKYYEACE NGRGAILLSV
ARGKVSEGID F
//
