ID   H3B2G8_LATCH            Unreviewed;       247 AA.
AC   H3B2G8;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 61.
DE   SubName: Full=FERM, ARH/RhoGEF and pleckstrin domain protein 1 {ECO:0000313|Ensembl:ENSLACP00000016089.1};
GN   Name=FARP1 {ECO:0000313|Ensembl:ENSLACP00000016089.1};
OS   Latimeria chalumnae (Coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000016089.1, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Proteomes:UP000008672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT   "The draft genome of Latimeria chalumnae.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000016089.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, dendritic spine
CC       {ECO:0000256|ARBA:ARBA00004552}. Synapse
CC       {ECO:0000256|ARBA:ARBA00034103}.
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DR   EMBL; AFYH01039124; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01039125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01039126; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01039127; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01039128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01039129; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01039130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01039131; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01039132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01039133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H3B2G8; -.
DR   Ensembl; ENSLACT00000016200.1; ENSLACP00000016089.1; ENSLACG00000013570.2.
DR   GeneTree; ENSGT00940000155318; -.
DR   HOGENOM; CLU_003623_1_4_1; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   Bgee; ENSLACG00000013570; Expressed in pelvic fin and 5 other cell types or tissues.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR   GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   CDD; cd17189; FERM_F1_FARP1; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR000798; Ez/rad/moesin-like.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR019747; FERM_CS.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR018979; FERM_N.
DR   InterPro; IPR018980; FERM_PH-like_C.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45858:SF2; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF09380; FERM_C; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF09379; FERM_N; 1.
DR   PRINTS; PR00935; BAND41.
DR   PRINTS; PR00661; ERMFAMILY.
DR   SMART; SM00295; B41; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF47031; Second domain of FERM; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS00660; FERM_1; 1.
DR   PROSITE; PS50057; FERM_3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT   DOMAIN          3..247
FT                   /note="FERM"
FT                   /evidence="ECO:0000259|PROSITE:PS50057"
SQ   SEQUENCE   247 AA;  28824 MW;  3964BD10ADC40EA5 CRC64;
     LYHPEHLFLH QSVQNHFSMQ IRAPGKVLLD AICSHLNLVE GDYFGLEFQD HRKVMVWLDL
     LKPIGKQIRR PKHAIIRFVV KFFPPDHTQL QEELTRQYLF ALQVKQDLGS NRLICNDSSA
     ALLVSHIVQS EIGDYDEALD REHLRNNKYI PQQGALEDKI IEFHRRHVFQ SGQTPAESDF
     QLLEIARRLE MYGIRLHPAK DREGTKINLA VANTGILVFQ GLTKINSFNW AKVRKLSFKR
     KRFLIKL
//