ID H3B4S9_LATCH Unreviewed; 1111 AA.
AC H3B4S9;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Tudor domain containing 7 {ECO:0000313|Ensembl:ENSLACP00000016900.1};
GN Name=TDRD7 {ECO:0000313|Ensembl:ENSLACP00000016900.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000016900.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000016900.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TDRD7 family.
CC {ECO:0000256|ARBA:ARBA00007740}.
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DR EMBL; AFYH01092993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01092994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01092995; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01092996; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01092997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01092998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01092999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01093000; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01093001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01093002; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3B4S9; -.
DR STRING; 7897.ENSLACP00000016900; -.
DR Ensembl; ENSLACT00000017019.1; ENSLACP00000016900.1; ENSLACG00000014886.1.
DR eggNOG; KOG2039; Eukaryota.
DR GeneTree; ENSGT00890000139482; -.
DR HOGENOM; CLU_283554_0_0_1; -.
DR InParanoid; H3B4S9; -.
DR OMA; CKGKWSR; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000014886; Expressed in chordate pharynx and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR CDD; cd09974; LOTUS_3_TDRD7; 1.
DR CDD; cd20427; Tudor_TDRD7_rpt1; 1.
DR CDD; cd20429; Tudor_TDRD7_rpt3; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 2.40.50.90; -; 3.
DR Gene3D; 3.30.420.610; LOTUS domain-like; 3.
DR InterPro; IPR041966; LOTUS-like.
DR InterPro; IPR025605; OST-HTH/LOTUS_dom.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR037978; TDRD7_LOTUS_3.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR047449; Tudor_TDRD7_rpt3.
DR PANTHER; PTHR22948; TUDOR DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22948:SF29; TUDOR DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF12872; OST-HTH; 1.
DR Pfam; PF00567; TUDOR; 2.
DR SMART; SM00333; TUDOR; 2.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 2.
DR PROSITE; PS51644; HTH_OST; 3.
DR PROSITE; PS50304; TUDOR; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 705..724
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 745..775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..79
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 243..313
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 353..423
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 522..580
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
FT REGION 123..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1111 AA; 124307 MW; 1AC7170DF58A76CF CRC64;
MSETEKELVS KMLRAVLQSS KNGVALSRLQ GEYRGLTGEF IPFKQLGYPT LEAFLKSIPS
VVKMEGGRVG GEVVCFAAVC SETAHIAKLV ARQRSSKKKV GGPVNCQMRL KHTAPVMQVG
KPKMTLRQPG YPSQPGRGGR RQNPPLTRGK GSFHGTGKPS SENYLNIEVT MTQGGGAARD
VSIQRHLSMP STRSERRLTL PPRFQKELQV HLSKNTGGDP NANWNENLSL GKPPAPDTAG
NLNVELVQCR LTEILTKFSN GIWASKLPQF YKDMYKQELN AEVLKHLEEW THICKIEKLP
NSGQSDVLLY PAKYRSPQTK CESDLLRPPK SLVIDKPTSP VFKPVTPPSL STVDSDLKQK
VAVLLVKYSS GLWANALPKV FEDTYKAKFP ENMLSNLESL SDICSVDYPI ANNPKKAILY
AKAVKQADAN QNATGQASVQ EDLQQIREQE FDQKHAEPLE KDLNPPPLTI PDEESPSVLV
VELANTNEVV IRYVGNDYSR AQELMEDKMK DYYKSSVATP TQTVSVDKLV AVKAEEDAWL
RAQVIAVEGE RVKVCYIDYG FNEIVEKNKL RNLERQFYSL SFQATKCKLA GLESFSDDPA
LLKCVELLAC GKILAVEILE RSDIPLVVLY DTSGEDDVNI NATCLKALHD KTLDLGLKAG
SSYTNVKITN VCSDGTVYCQ IPSKGLRKLN DGLDKIDQFF GTRQITSEFF VSIPFCGKYC
LFNYKGKWTR IEIYNPYSEK ELSLIFLYPF VLSFVFLLAF FPEVFPVFCT LVVVFTVGPQ
ALKCCLADLP FNIGMWTPDA VLWLRDTVLN CSECSVKVVK VEAAKGLVHI YLFTSKNFPN
PDRSINRQIA NADLWKHQKD VFLSVSNRAV GTCKARGDTC AGSASDSMRP KKPLGIAAPK
TVADRSSVLH TTELPPLLPL PKPSEHMDVY INVAHHPGHF VFQPWQELHK LEVLMEEMIL
CYNTTEEQSL TIEKNKIYAA KVDNKWYRVL VKGVLTNGLV SIYELDHGRH ELISYRNVQP
LIEKFRQLPF QAVTAQLAGM KSEQWSEEAA VVFRHHVAKK PLVALIQTVC ESTKPWDRKV
VAYLVDTSLP DTDTWIHDLM SEYLVELSKA V
//
