ID H3B546_LATCH Unreviewed; 355 AA.
AC H3B546;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000017017.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000017017.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000256|ARBA:ARBA00005683,
CC ECO:0000256|RuleBase:RU003500}.
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DR EMBL; AFYH01084873; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01084874; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01084875; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3B546; -.
DR STRING; 7897.ENSLACP00000017017; -.
DR Ensembl; ENSLACT00000017139.1; ENSLACP00000017017.1; ENSLACG00000014986.1.
DR eggNOG; KOG3913; Eukaryota.
DR GeneTree; ENSGT00940000159654; -.
DR HOGENOM; CLU_033039_1_4_1; -.
DR InParanoid; H3B546; -.
DR OMA; YRITRDC; -.
DR TreeFam; TF105310; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000014986; Expressed in pelvic fin.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd19336; Wnt_Wnt4; 1.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR009142; Wnt4.
DR InterPro; IPR043158; Wnt_C.
DR InterPro; IPR018161; Wnt_CS.
DR PANTHER; PTHR12027:SF101; PROTEIN WNT-4; 1.
DR PANTHER; PTHR12027; WNT RELATED; 1.
DR Pfam; PF00110; wnt; 1.
DR PRINTS; PR01844; WNT4PROTEIN.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
DR PROSITE; PS00246; WNT1; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU003500};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|RuleBase:RU003500}.
SQ SEQUENCE 355 AA; 39119 MW; 9914FCEB1A9C5250 CRC64;
NSSQSALQQD TMFVSSVVAT GTCNALRYLA KLSSVGSISE EETCEKLKGL IQRQVQICKR
NVEVMDSVRR GAQLAIEECQ FQFRNRRWNC STLDTLPVFG KVVTQGGLGT REAAFVYAIS
SAGVAFAVTR ACSSGELEKC GCDRTVHGVS PEGFQWSGCS DNIAYGVAFS QSFVDVRERS
KGASSSRALM NLHNNEAGRK AILNNMRVEC KCHGVSGSCE VKTCWKAMPP FRKVGNVLKE
KFDGATEVEQ KKIGSTKVLV PKNSQFKPHT DEDLVYLDSS PDFCDHDLKN GVLGTSGRQC
NKTSKAIDGC ELMCCGRGFH TEEVEVVDRC SCKFHWCCFV KCKQCRKVVE MHTCR
//
