ID H3B5X6_LATCH Unreviewed; 620 AA.
AC H3B5X6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=calcium/calmodulin-dependent protein kinase {ECO:0000256|ARBA:ARBA00012434};
DE EC=2.7.11.17 {ECO:0000256|ARBA:ARBA00012434};
GN Name=CAMK2A {ECO:0000313|Ensembl:ENSLACP00000017297.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000017297.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000017297.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000902};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.17; Evidence={ECO:0000256|ARBA:ARBA00000517};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. CaMK subfamily. {ECO:0000256|ARBA:ARBA00005354}.
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DR EMBL; AFYH01013090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01013091; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01013092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3B5X6; -.
DR STRING; 7897.ENSLACP00000017297; -.
DR Ensembl; ENSLACT00000017424.1; ENSLACP00000017297.1; ENSLACG00000015235.1.
DR eggNOG; KOG0033; Eukaryota.
DR GeneTree; ENSGT00940000155150; -.
DR HOGENOM; CLU_000288_71_3_1; -.
DR InParanoid; H3B5X6; -.
DR OMA; XESSEST; -.
DR TreeFam; TF315229; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0004683; F:calmodulin-dependent protein kinase activity; IEA:UniProtKB-EC.
DR CDD; cd14086; STKc_CaMKII; 1.
DR Gene3D; 3.10.450.50; -; 1.
DR Gene3D; 6.10.140.620; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR013543; Ca/CaM-dep_prot_kinase-assoc.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR032710; NTF2-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24347:SF436; CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE; 1.
DR PANTHER; PTHR24347; SERINE/THREONINE-PROTEIN KINASE; 1.
DR Pfam; PF08332; CaMKII_AD; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF54427; NTF2-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 1..228
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 318..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..440
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..494
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 620 AA; 68729 MW; 7D0576D5489F6F05 CRC64;
NSQNASLPDH QKLEREARIC RLLKHPNIVR LHDSIAEEGH HYLVFDLVGG GGFFNNRVQQ
VYFSSGSTGT HCIQQILEAV LHCHQMGVVH RDLKPENLLL ASKLKGAAVK LADFGLAIEV
EGDQQAWFGF AGTPGYLSPE VLRKDPYGKP VDLWACGVIL YILLVGYPPF WDEDQHRLYQ
QIKAGAYDFP SPEWDTVTPE AKDLINKMLT INPAKRITAA EVLKHPWISH RSTVASCMHR
QETVDCLKKF NARRKLKGAI LTTMLATRNF SAGQQGSAPS GGTRVIAQWA WGQCEGTKST
ANKKNDGVKV RSSSHLWDIN TASTKGELGP TAGQPSTGEV RAPRDGMQES SESTNTTIED
EDTREPPTPL KETLYPPETL SPDQQYQISY LQKPSILNSL PNPVPENSSV LNSLLNPPPE
KPSILNSPLN PPPEKPSILN SLPNPVPEKS SILNSPPNPP PEKPSILNSP PKPPPKKPSI
LNSPPNPPPE KPSILNSLLN PALNNNYEKA IKRMCDPSVT AFEPEALGNL VEGLDFHRFY
FENLWSKNNK PVHTTILNPH IHLIGEEAAC IAYIRITQYM DSNGIPRTAQ SEETRIWHRR
DGKWQIVHFH RSGAPSALVK
//
