ID H3B654_LATCH Unreviewed; 491 AA.
AC H3B654;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Major facilitator superfamily domain containing 12 {ECO:0000313|Ensembl:ENSLACP00000017375.2};
GN Name=MFSD12 {ECO:0000313|Ensembl:ENSLACP00000017375.2};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000017375.2, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000017375.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01099213; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01099214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01099215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01099216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005999123.1; XM_005999061.2.
DR AlphaFoldDB; H3B654; -.
DR STRING; 7897.ENSLACP00000017375; -.
DR Ensembl; ENSLACT00000017503.2; ENSLACP00000017375.2; ENSLACG00000015304.2.
DR GeneID; 102347809; -.
DR KEGG; lcm:102347809; -.
DR CTD; 561964; -.
DR eggNOG; KOG4830; Eukaryota.
DR GeneTree; ENSGT00390000005318; -.
DR HOGENOM; CLU_030068_1_0_1; -.
DR InParanoid; H3B654; -.
DR OMA; GLYTAWM; -.
DR OrthoDB; 2902828at2759; -.
DR TreeFam; TF314080; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000015304; Expressed in post-anal tail muscle and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015293; F:symporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:InterPro.
DR CDD; cd17491; MFS_MFSD12; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR039672; MFS_2.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR11328; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11328:SF28; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 12; 1.
DR Pfam; PF13347; MFS_2; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 84..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 357..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 491 AA; 53849 MW; 80AB3ED55FE1CBEF CRC64;
MADQPSLSLC GRLSYSIGHF LNDLCASMWF TYLLVYYHAV LGFNNSYAGV LLLVGQVADG
VCTPLIGYES DQSRGCGTYG KRKSWHLVGT ISVVLSFPFI FNPCMGCTES TPHWVALVYF
IPFIVIFQFG WAATQISHLS LIPELVASDH EKVELTALRY AFTVTANIVV YGVAWLLFHF
QVGHSDDPSI SKSLGSQDIP VFRNLALIIV GLGTLFSILF HVGTKEKASH SDTTPVADEH
TPLVDKTLTA PTSPLLLWKH WLKEPAFYQV AALYMCTRLI VNLSQTYIAM YLTNSLHLPK
KYIATIPLVM YLSGFLFSFL MKPINKLIGR NVTYLVGLLI IFAFAYWILL VQNIGHAVYG
AAVLLGTGSA TILITSLSMT ADLIGANTQS GAFVYGAMSF TDKLANGIAV VIIQNLHPCH
TQKCCSACVP FYHWVMIIVT GGIAVMAAFC LCTIMLWPIR VRVRCVSVSG LQGSPRDVES
RAEGLLNGSV N
//
