ID H3B681_LATCH Unreviewed; 1079 AA.
AC H3B681;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Adenosine deaminase RNA specific {ECO:0000313|Ensembl:ENSLACP00000017402.1};
GN Name=ADAR {ECO:0000313|Ensembl:ENSLACP00000017402.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000017402.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000017402.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AFYH01073952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01073953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01073954; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01073955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01073956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01073957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01073958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01073959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3B681; -.
DR Ensembl; ENSLACT00000017530.1; ENSLACP00000017402.1; ENSLACG00000015329.2.
DR GeneTree; ENSGT00940000157243; -.
DR HOGENOM; CLU_005382_0_0_1; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000015329; Expressed in pectoral fin and 2 other cell types or tissues.
DR GO; GO:0003726; F:double-stranded RNA adenosine deaminase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd19913; DSRM_DRADA_rpt1; 1.
DR CDD; cd19914; DSRM_DRADA_rpt2; 1.
DR CDD; cd19915; DSRM_DRADA_rpt3; 1.
DR Gene3D; 3.30.160.20; -; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR002466; A_deamin.
DR InterPro; IPR044456; ADAR1_DSRM_1.
DR InterPro; IPR044457; ADAR1_DSRM_3.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR042371; Z_dom.
DR PANTHER; PTHR10910:SF107; DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE DEAMINASE; 1.
DR PANTHER; PTHR10910; EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN; 1.
DR Pfam; PF02137; A_deamin; 1.
DR Pfam; PF00035; dsrm; 3.
DR Pfam; PF02295; z-alpha; 2.
DR SMART; SM00552; ADEAMc; 1.
DR SMART; SM00358; DSRM; 3.
DR SMART; SM00550; Zalpha; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 3.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS50141; A_DEAMIN_EDITASE; 1.
DR PROSITE; PS50137; DS_RBD; 3.
DR PROSITE; PS50139; Z_BINDING; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00266}.
FT DOMAIN 31..97
FT /note="Z-binding"
FT /evidence="ECO:0000259|PROSITE:PS50139"
FT DOMAIN 150..214
FT /note="Z-binding"
FT /evidence="ECO:0000259|PROSITE:PS50139"
FT DOMAIN 364..432
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 474..542
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 602..670
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 738..1075
FT /note="A to I editase"
FT /evidence="ECO:0000259|PROSITE:PS50141"
FT REGION 122..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1079 AA; 118534 MW; B0203F8FB590E22C CRC64;
RVDRPEITDS LSLTRSSSKV QELCTGFHRL TLGGGDNQED ILNILKGLEQ GRTLSAFQIA
KQLGIKKKVV NHFLYKLLKQ GQVCREGDRP PLWNIVVQLE FDKLSPGRQL IRSSKEEDVI
VEAEEGSLGT ATSESEDESS VESSQEEDEA VNMADLKEQI CEYLFGVKNS TALSIAKNVG
LKRAKDVNNV LYALEKQGDI SKENTFPPHW SLTEKKRERM ENKKKASEVE VKKEPEEEAE
SEVAKMELPD NVAEAEAEAT AAVSPPIAET NEKIENGKNV VKVPKEENEM PLVETGAGGK
SKGPSFGALP YDSIENGQWA SDDIPFDLNV IEETMEQSSH VSGPPGGGEK IGELEKLQAC
QLKNPVSGLM EYAQYNGLNC EFALLNQSGP SHDPRFQIQA VIGGRRFPTA EASSKKTAKK
EAAASALKTL LREAGGEQDA AEPQPSEPSD LEMEAVSTEI PNFLFTAALP VGKNPISMLM
EYSQKSGNTC MFQMIGQEGP PHDPKFTFRV KVGEQMFPVA VANSKKVAKQ IAAENAVRVL
MGESPDNLLS AKKKKSCLLS ANFVCSVTLF QMVSDTPKDV PFDLAAARAA GMGDLINYLN
KNAISGLLEY ARSKGFAADL KLIDESGPPH DPKFTYQAKV GGRWFPAVSA NNKKQAKQEA
ADAALRVLIG EAEKAVRTGE VISELPVTGS TLHDRIAMLS HQRFNNLTAR IQHSLQGRKI
LAAIIMRKGE DDIGTVVSIG TGNRCVKGEE LSLKGETVND CHAEIISRRG FFFLLRFLYS
ELMKFDPASA EQSFLEVVSD GRMKIKTGVT FHLYISTAPC GDGALFDKSC SEPPAVEGDN
EHHPLFENVK QGKLRTKVEN GEGTIPVESS DIVPTWDGIQ HGERLRTMSC SDKILRWNVL
GLQGALLSHF LHPVYLSSVT LGYLYSQGHL ARAICCRMSR DGNAFQEGLP SPFVLNHPQV
GRVSVYDSTR QTGKTKESSV NWCLADENVE VLDGTKGKVD GPRLEISRVS KINMYQLFQQ
ICTKTDRKDL LSHGSYQEAK EAATDFQKAK VHFVQALEQM GYGNWIRKPL EEKSFVCTE
//
