ID H3B6B4_LATCH Unreviewed; 1390 AA.
AC H3B6B4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Protein tyrosine phosphatase receptor type S {ECO:0008006|Google:ProtNLM};
GN Name=PTPRSA {ECO:0000313|Ensembl:ENSLACP00000017435.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000017435.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000017435.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01051228; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01051229; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01051230; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01051231; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01051232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01051233; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01051234; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01051235; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01051236; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01051237; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSLACT00000017563.1; ENSLACP00000017435.1; ENSLACG00000015357.1.
DR GeneTree; ENSGT00940000153617; -.
DR HOGENOM; CLU_001645_4_3_1; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000015357; Expressed in chordate pharynx and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 8.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF8; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S; 1.
DR Pfam; PF00041; fn3; 7.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 8.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022912};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1390
FT /note="Protein tyrosine phosphatase receptor type S"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003580968"
FT TRANSMEM 1253..1276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..114
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 126..213
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 223..305
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 312..402
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 407..501
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 505..594
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 599..696
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 701..809
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 810..906
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 907..1002
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1006..1090
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 385..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1390 AA; 154008 MW; 5B31D8154C734A75 CRC64;
MLNISLPLSF LVILNIQAWA SYGPLFIKIP TDQIGVSGGV ASFVCQATGD PKPRVTWNKK
GKKVNSQRFE TIEFDEGAGA VLRIQPLRTP RDENVYECIA ENSMGELTVS AKLTVLREDQ
LPAGFPNIDM GPQLKVVERT RTATMLCAAS GNPDPEITWF KDFLPVDPGA SKGRIKQLRS
GALQIEQSEE TDQGKYECVA SNSAGVRYSA PANLYVRVRR VPPRFSILPT SHEIMPGGNI
NITCVAVGSP MPYVKWMLGA EDLTPEDEMP VGRNVLELNG IKESANYTCV AMSSLGVIES
TAQISVKSLP KPPGTPIVTE TTATSITITW DSGNPDPVSH YVIQYKPKST GGPYQIKDGI
TTTRYSIGGL SPNSEYEIRV SAVNTIGQGP PSDPVDTQTG EQAPASSPRN VQARMLSSTT
MIIQWEAPEE PNGQIRGYRV YFTMDPDQSV SNWQKQNVDD SHLTTVGSLV PEETYSVRVL
AFTSVGDGPL SDAIRVKTQQ GVPGQPMNFK AKVKTETAIE LSWTPPRQED ILKYELLYKE
GEHGKEVKKV FDPTTSYTID ELRPNTEYFF QLAARSEKGT GAFTPYVRER THQSKPSAPP
QDVKVTSSSS TTLLVSWHPP PAESQNGALV EYSVRYQAVE GEDTEPQEVK GIPPSTYQLL
LQGLEKWTKY RVSVVAHTKV GPGPENTPVV VRTDEDVPSA PPRKVEVEVL NSSAIKVLWR
SPLLNKQHGQ IRGYQVHYVK VENGEARGLP HIKDVMLSDA QWETDDTAEY EMVISGLQPE
TTYSITVAAY TTKGDGARSK AKLVVTKGPV PGRPRLSVQQ TLHNTVVLQW QPASKSASQV
QGYRLQFGRK DVTPLDTLEF AEQEEEYTVS VHKGASYIFK LAAKNQAGFG EEAVKELTIP
EDVPQGYPQI LEMTNVTSMS IQFGWLPPVR AERNGVITKY TVIYKEASSQ SSPTEKTVWP
PETSYMMTGL KSNTAYDVKV QAHTSKGPGP CSPIIQYRTL PLDQVFPKNF KVKIVMKTSV
LLSWEFPENY NSPIPYKIQY NRQSVDVDGR TTKKLITNLR PNTFYNFVLT NRGNSMGGLQ
QNVAARTAPA ILGTKPTLVQ KLDPDGTLTA VLSHIGATSS VKTYYIIVVP LAKSRGSFVN
PWGSPEEMDL EELLHDMSKL RRRSLRFSRQ LGHQKSYIAA RFDTLPPRFT LGDQSYYGGF
ENKALELGQE YVFFILAVLD NTESKMYAAS PYSDSFMSAG PDPQPIIDGE EGLIWVIGPV
LAVVFIICIV IAILLYKNKR KDSEPRTKCL LNNAEITPHH PTDPVEMRRI NFQTPGMLSH
PPIPISELAE HTEHMKANDN LKLSQEYESI DPGQQFTWEH SNLEVNKPKN RYANVIAYDH
SRVILSPIEG
//
