ID H3B6T9_LATCH Unreviewed; 612 AA.
AC H3B6T9;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Macoilin {ECO:0000256|ARBA:ARBA00021882};
DE AltName: Full=Transmembrane protein 57 {ECO:0000256|ARBA:ARBA00031129};
GN Name=MACO1 {ECO:0000313|Ensembl:ENSLACP00000017610.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000017610.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000017610.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in the regulation of neuronal activity.
CC {ECO:0000256|ARBA:ARBA00003440}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Nucleus membrane
CC {ECO:0000256|ARBA:ARBA00004232}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004232}. Rough endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004269}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004269}.
CC -!- SIMILARITY: Belongs to the macoilin family.
CC {ECO:0000256|ARBA:ARBA00008298}.
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DR EMBL; AFYH01052453; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01052454; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3B6T9; -.
DR STRING; 7897.ENSLACP00000017610; -.
DR Ensembl; ENSLACT00000017740.1; ENSLACP00000017610.1; ENSLACG00000015510.1.
DR eggNOG; KOG1821; Eukaryota.
DR GeneTree; ENSGT00390000016613; -.
DR InParanoid; H3B6T9; -.
DR OMA; ENTHADT; -.
DR TreeFam; TF324023; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000015510; Expressed in chordate pharynx and 6 other cell types or tissues.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0023041; P:neuronal signal transduction; IEA:InterPro.
DR InterPro; IPR019130; Macoilin.
DR PANTHER; PTHR47464; MACOILIN; 1.
DR PANTHER; PTHR47464:SF2; MACOILIN; 1.
DR Pfam; PF09726; Macoilin; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 74..104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 209..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 382..550
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 223..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 612 AA; 70637 MW; 416E93292C79E417 CRC64;
MKRRNADCSK LRRPLKRNRI TEGIYGSTFL YLKFLVVWAL VLLADFVLEF RFEYLWPFWL
FIRSVYDSFR YQGLAFSVFF VCVAFTSDII CLLFIPVQWL FFAASTYVWV QYVWHTERGV
CLPTVSLWIL FVYIEAAIRF KDLKNFHVDL CRPFAAHCIG YPVVTLGFGF KSYVSYKMRL
RKQKEVQKEN EFYMQLLQQA LPPEQQMLQR QEREAEEVTT AKGISEVDST QLPQHNGGIP
VNKKISTALP ELEYREKGKE KEKDKKPSLG INNNILQSVD SKIQEIEYME NHINSRRLNN
ELGGSTENLL KEDSGSASSK NFKNAGGMVN SSPRSHSSSN GSLPTSSKNE KKQKCTSKNL
STHKDLMDNC IPNNQLSKPD TLVRLEQDIK KLKADLQASR QTEQELRSQI SSLSSTERGI
RSEIGQLRQE NELLQNKLHN AVQMKQKDKQ TITQLEKKLK AEQEARAFVE KQLLEEKKRK
KLEEATAARA VALAAASRGE CTETLRSRIR ELETECKKLT IDMKVKEDQI RELEMKVQEL
RKYKENEKDT EVLMSALSAM QDKTQHLENS LSAETRIKLD LFSALGDAKR QLEIAQGKPL
YVMCTVCRVF KL
//
