ID H3B6W3_LATCH Unreviewed; 322 AA.
AC H3B6W3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Beta-sarcoglycan {ECO:0000256|ARBA:ARBA00015329};
GN Name=SGCB {ECO:0000313|Ensembl:ENSLACP00000017634.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000017634.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000017634.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the sarcoglycan complex, a subcomplex of the
CC dystrophin-glycoprotein complex which forms a link between the F-actin
CC cytoskeleton and the extracellular matrix.
CC {ECO:0000256|ARBA:ARBA00002860}.
CC -!- SUBUNIT: Cross-link to form 2 major subcomplexes: one consisting of
CC SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The
CC association between SGCB and SGCG is particularly strong while SGCA is
CC loosely associated with the other sarcoglycans.
CC {ECO:0000256|ARBA:ARBA00026041}.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004274}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004274}.
CC -!- SIMILARITY: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
CC {ECO:0000256|ARBA:ARBA00007574}.
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DR EMBL; AFYH01094126; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094127; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094129; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3B6W3; -.
DR STRING; 7897.ENSLACP00000017634; -.
DR Ensembl; ENSLACT00000017764.1; ENSLACP00000017634.1; ENSLACG00000015531.1.
DR eggNOG; ENOG502QUW4; Eukaryota.
DR GeneTree; ENSGT00390000008110; -.
DR HOGENOM; CLU_066515_1_0_1; -.
DR InParanoid; H3B6W3; -.
DR OMA; KGVQGME; -.
DR TreeFam; TF313538; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000015531; Expressed in muscle tissue and 6 other cell types or tissues.
DR GO; GO:0016012; C:sarcoglycan complex; IEA:InterPro.
DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR GO; GO:0007517; P:muscle organ development; IEA:InterPro.
DR InterPro; IPR006875; Sarcoglycan.
DR InterPro; IPR027659; Sgcb.
DR PANTHER; PTHR21142:SF2; BETA-SARCOGLYCAN; 1.
DR PANTHER; PTHR21142; SARCOGLYCANS; 1.
DR Pfam; PF04790; Sarcoglycan_1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 79..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 322 AA; 35997 MW; 4B9F911946D0689B CRC64;
MAAEQVCGRD VLWVFFFLNG RTWELNQSSN GPVKRSMREK AVERRNINKE HNSNFKAGYI
PINEERLHRT GLRGRKGNLA ICVIVVLFLL AVINLIITLV IWTVIRIGPS GCDSMEFHES
GLLRFKQESD MGVIHPLHKS TVGGRRNEDL VITGNNQPVV FQQGTTKLSV EKEKTSITSD
IGMAFVDPRT QKTLFSTDYE THEFHLPEGV KTLNVQKAST GRITSNATSD LNIKAGGKAI
VRGNEGVFIM GKTIEFRMGG YMELKAINLV STEINIILTL FWKASMKSWF GLGTYYFSQV
CIDDAVWDLG CQTSDNPCGA TR
//
