ID   H3B6Y2_LATCH            Unreviewed;       734 AA.
AC   H3B6Y2;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 61.
DE   SubName: Full=Sortilin 1 {ECO:0000313|Ensembl:ENSLACP00000017653.1};
GN   Name=SORT1 {ECO:0000313|Ensembl:ENSLACP00000017653.1};
OS   Latimeria chalumnae (Coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000017653.1, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Proteomes:UP000008672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT   "The draft genome of Latimeria chalumnae.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000017653.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AFYH01035568; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01035569; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01035570; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01035571; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01035572; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01035573; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H3B6Y2; -.
DR   STRING; 7897.ENSLACP00000017653; -.
DR   Ensembl; ENSLACT00000017783.1; ENSLACP00000017653.1; ENSLACG00000015550.1.
DR   eggNOG; KOG3511; Eukaryota.
DR   GeneTree; ENSGT01030000234563; -.
DR   HOGENOM; CLU_013596_0_0_1; -.
DR   InParanoid; H3B6Y2; -.
DR   OMA; GGHWSYL; -.
DR   TreeFam; TF324918; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   Bgee; ENSLACG00000015550; Expressed in muscle tissue and 6 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.10.70.80; -; 1.
DR   Gene3D; 3.30.60.270; -; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR12106:SF23; SORTILIN; 1.
DR   PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR   Pfam; PF15902; Sortilin-Vps10; 1.
DR   Pfam; PF15901; Sortilin_C; 1.
DR   SMART; SM00602; VPS10; 1.
DR   SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        659..680
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          32..645
FT                   /note="VPS10"
FT                   /evidence="ECO:0000259|SMART:SM00602"
SQ   SEQUENCE   734 AA;  81558 MW;  9F0DA88CD930C0D8 CRC64;
     QYNFEDLSGL VSLAWVGDGT GILLALTTFQ VPLRWITFGQ SKLYRSEDYG KTFSDITHLI
     NNTFIRTEFG IAIGPENSGK VILTGDVSGG SLGGRIFRSL DFGKHFIRTD LPFHPLTQIS
     YHPKNFSILL ALSIKNTLWL SSNFGETWTN LHDFVCLVKW GHGDMIYFTT HTNKTCSLDR
     GQLELRKTTD FGKTFETIGS KIYSFGIGGR FLFASVMTGK VRTRRFHLYT VFKKKKKTFE
     QFPPPGTSQA YSLLKGDADV GRAGSKKNLD TGFGTIYTSD DRGVVYSKSL ERHLYTTTGG
     ETDFTNVTSL RGVYITSVLS EDESVQSVIS FDQGGEWKPL RKPDNAVCDS TAKNKDECSL
     HIHASYSIAQ KVNVPMLPLS EPNAIGLIIA HGSVGDAISI MKPDVYVSDD GGYSWMKVLA
     GPHHYAILDS GGLIVAVEHS QLPISVIKYS TDEGQCWYSY KFTSEPVYFT GLASEPGAKS
     MNVSIWGYKK GLLALYWISI TIDFEELLTR DCQDEDYTKW LAHSSDLNDP SDGCILGYKE
     QYRRLRKAAV CRNGRGYIVV KQPSVCICTL ADFLCDFGYY RPENQSECIE QLDLKGHDLE
     FCLHGKQELL LTSGYRKIPG DKCEGGAMPS RTVKDMRTKC TSNPMEPSQL SKNSSSNSAL
     IIVAVVLLLV IATIGGVLFI KKYVCGGRFL VHRYSVLQQH ADANGIDIAD ELDATLSSRG
     KSNYHDDSDE DLLE
//