ID H3B707_LATCH Unreviewed; 393 AA.
AC H3B707;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Tumor necrosis factor receptor superfamily member 6 {ECO:0008006|Google:ProtNLM};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000017678.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000017678.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AFYH01040838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01040839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01040840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3B707; -.
DR STRING; 7897.ENSLACP00000017678; -.
DR Ensembl; ENSLACT00000017808.1; ENSLACP00000017678.1; ENSLACG00000015570.1.
DR eggNOG; ENOG502RBEC; Eukaryota.
DR GeneTree; ENSGT00930000151070; -.
DR HOGENOM; CLU_038161_1_0_1; -.
DR InParanoid; H3B707; -.
DR OMA; CAKCKPG; -.
DR TreeFam; TF333916; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000015570; Expressed in pectoral fin and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08315; Death_TRAILR_DR4_DR5; 1.
DR CDD; cd10580; TNFRSF10; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR034024; TNFRSF10_N.
DR InterPro; IPR034029; TNFRSF10A/B_death.
DR PANTHER; PTHR46874; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6; 1.
DR PANTHER; PTHR46874:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00020; TNFR_c6; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00208; TNFR; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS00652; TNFR_NGFR_1; 2.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 131..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..81
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 40..81
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT REPEAT 82..123
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 82..123
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 302..386
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT DISULFID 60..73
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 63..81
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 83..98
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 105..123
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 393 AA; 44379 MW; 2C3F6A58C808D0E3 CRC64;
ETCGKNQYLF QKGHCCLMCP KGHYVKTPCV APNISVICAP CIEGKEYTED ANGLERCLSC
RRCRKDQDVV SVCTAEKNTV CQCKQGTFCQ PNRTCEICQR CKTSCPKDLE KLSDCNATTD
LTCGPSLQGN VWIIVGPILA FLVLSICVVF FYWRCHRANS AFALFWGGRG GEETDCFILE
KQKGVHKTIQ DLKRQHIHTG PEAQDGGHSV HNLFSAAGNV SCFYRPTCTY QSGSPIKNIW
CVCTRVHVQV LLHAPSKKCT CSLKMQLVTI FKISGLQTVA ILLQEEVTRP LVAAKELPEV
LTKSFYTFIN EVPNKEWKKF MRLLHLTDNE IWVAERNHPS DIREQYFQML NTWQSCTGKE
ASINTLLQTL RDMNLKGVEE RITASLIQEG IYK
//
