ID H3B9E8_LATCH Unreviewed; 431 AA.
AC H3B9E8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Growth differentiation factor 2 {ECO:0000313|Ensembl:ENSLACP00000018519.2};
GN Name=GDF2 {ECO:0000313|Ensembl:ENSLACP00000018519.2};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000018519.2, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000018519.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; AFYH01039679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3B9E8; -.
DR STRING; 7897.ENSLACP00000018519; -.
DR Ensembl; ENSLACT00000018652.2; ENSLACP00000018519.2; ENSLACG00000016304.2.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00940000159802; -.
DR HOGENOM; CLU_020515_2_0_1; -.
DR InParanoid; H3B9E8; -.
DR OMA; GTFDLRM; -.
DR TreeFam; TF316134; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR CDD; cd19400; TGF_beta_BMP9; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF157; GROWTH_DIFFERENTIATION FACTOR 2; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..431
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003580596"
FT DOMAIN 319..431
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 431 AA; 49208 MW; 732906F726897BDB CRC64;
MNPFTFLATL IALNLLASYT RCKPVDGWRN MFLRQEENDN FSEDDVPEGE EEEASVDFNM
FLENMKEEFL KSLNLSGVPS QERSSPQTLQ FMIDLYNRYA TDKSSMPASN IVRSFSTEDV
ASIPLGEKKT ATKHILLFNL SIPSHEEVTM AELRLYTFCN SIKELSKTLK AKVAIYDLED
RVESETTMEP KLSLIVSKEI NCRKGGWETF EVTNSIKRWI QFDKTNNIFE VHFQSLGDGN
VKCESLHNSV DLDRKTAPLL VVFSDDRSNE RLEAREELKQ LIFHEQASEL DTMGRNDTID
QEQWSHSQFS VKSHHISSRT KRSTGGNHCR KASLRVDFKE IGWDSWIVAP KQYDAFECKG
VCYFPLTDNV TPTKHAIIQS LVHLKNPKKA AKACCVPTKL DSISVLYKDD AGVLTLKYKY
EGMKVAECGC R
//
