ID H3B9K4_LATCH Unreviewed; 447 AA.
AC H3B9K4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Exostosin glycosyltransferase 1 {ECO:0000313|Ensembl:ENSLACP00000018575.1};
GN Name=EXT1 {ECO:0000313|Ensembl:ENSLACP00000018575.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000018575.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000018575.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004648}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 47 family.
CC {ECO:0000256|ARBA:ARBA00010271}.
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DR EMBL; AFYH01057455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01057456; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01057457; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01057458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01057459; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01057460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01057461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01057462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01057463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01057464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_014343012.1; XM_014487526.1.
DR AlphaFoldDB; H3B9K4; -.
DR STRING; 7897.ENSLACP00000018575; -.
DR Ensembl; ENSLACT00000018708.1; ENSLACP00000018575.1; ENSLACG00000016356.1.
DR GeneID; 102353460; -.
DR KEGG; lcm:102353460; -.
DR CTD; 2131; -.
DR eggNOG; KOG1021; Eukaryota.
DR GeneTree; ENSGT00940000155321; -.
DR HOGENOM; CLU_013906_2_0_1; -.
DR InParanoid; H3B9K4; -.
DR OMA; PEYSTHI; -.
DR OrthoDB; 1220028at2759; -.
DR TreeFam; TF314231; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000016356; Expressed in muscle tissue and 3 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050508; F:glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0050509; F:N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR InterPro; IPR004263; Exostosin.
DR InterPro; IPR040911; Exostosin_GT47.
DR InterPro; IPR015338; GT64.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR48261; ACETYLGLUCOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR48261:SF2; EXOSTOSIN-1-LIKE; 1.
DR Pfam; PF03016; Exostosin; 1.
DR Pfam; PF09258; Glyco_transf_64; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..447
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003580605"
FT DOMAIN 23..96
FT /note="Exostosin GT47"
FT /evidence="ECO:0000259|Pfam:PF03016"
FT DOMAIN 181..430
FT /note="Glycosyl transferase 64"
FT /evidence="ECO:0000259|Pfam:PF09258"
SQ SEQUENCE 447 AA; 51463 MW; BA70201493F943BB CRC64;
MSALFCCVLQ VLTCLLLFPS NRYDYREMLH NATFCLVPRG RRLGSFRFLE ALQAACIPVM
LSNGWELPFS EVVDWNQAAV IGDERLLLQI PSTIRSIHQD KILALKQQTQ FLWEAYFSSV
EKIVLTTLEI IQDRILKHIS RNSLIWNKHP GGLFVLPQYS TYLGEFPFYY ANLGLKPSPK
FTAVIHAVTP LVSQSQPILK LLVAVSKSQY CAQIIVLWNC DKPLPAKHRW PATSVPVVVI
EGASKVMSSR FLPYDNIATD AILSLDEDTV LSTTEVDFAF TVWLSFPERI VGYPARSHFW
DSTKERWGYT SKWTNDYSMV LTGAAIYHKY YHYLYTHYLP ASLKNMVDQL ANCEDILMNF
LVSAVTKLPP IKVTQKKQYK ETMMGQTSRA SRWADPDHFA QRQTCMNTFA TWFGSMPLIH
SQMRLDPVLF KDQVSILRKK YRDIERL
//
