ID H3B9W5_LATCH Unreviewed; 529 AA.
AC H3B9W5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=DNA-dependent metalloprotease SPRTN {ECO:0000256|ARBA:ARBA00023885};
DE AltName: Full=Protein with SprT-like domain at the N terminus {ECO:0000256|ARBA:ARBA00030396};
GN Name=SPRTN {ECO:0000313|Ensembl:ENSLACP00000018686.2};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000018686.2, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000018686.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Spartan family.
CC {ECO:0000256|ARBA:ARBA00010724}.
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DR EMBL; AFYH01052655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005994013.1; XM_005993951.2.
DR AlphaFoldDB; H3B9W5; -.
DR STRING; 7897.ENSLACP00000018686; -.
DR Ensembl; ENSLACT00000018819.2; ENSLACP00000018686.2; ENSLACG00000016452.2.
DR GeneID; 102365483; -.
DR KEGG; lcm:102365483; -.
DR CTD; 83932; -.
DR eggNOG; KOG3931; Eukaryota.
DR GeneTree; ENSGT00390000003585; -.
DR InParanoid; H3B9W5; -.
DR OrthoDB; 24062at2759; -.
DR TreeFam; TF314762; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000016452; Expressed in pelvic fin and 6 other cell types or tissues.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR InterPro; IPR006642; Rad18_UBZ4.
DR InterPro; IPR044245; Spartan.
DR InterPro; IPR006640; SprT-like_domain.
DR PANTHER; PTHR21220:SF0; DNA-DEPENDENT METALLOPROTEASE SPRTN; 1.
DR PANTHER; PTHR21220; UNCHARACTERIZED; 1.
DR Pfam; PF10263; SprT-like; 1.
DR SMART; SM00731; SprT; 1.
DR SMART; SM00734; ZnF_Rad18; 1.
DR PROSITE; PS51908; ZF_UBZ4; 1.
PE 3: Inferred from homology;
KW Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PROSITE-
KW ProRule:PRU01256};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|PROSITE-
KW ProRule:PRU01256}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01256}.
FT DOMAIN 505..529
FT /note="UBZ4-type"
FT /evidence="ECO:0000259|PROSITE:PS51908"
FT REGION 252..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 529 AA; 58973 MW; AA08D4861292CA53 CRC64;
MEDGDFLLAL QLQQQFDQEE NSYLPFDSAG SFSRHPPRDA GPDGSGAGGS VAYGGLGVAT
GKPLSIVDEA WEFLDPNPDV RALFLEFNSV FFWGKLAGVE VRWSPRMTLC AGLCCYEGRG
GLCSIRLSEP LLKLRPRKDL VETLLHEMIH AFLFVTNNNK DHDSHGAEFC KHMSRINKTT
GANITIYHTF HDEVEEYRQH WWRCNGPCQN RKPFFGYVKR AMNRPPSARD PWWAHHQQTC
GGTYTKIKEP ENYKKKGKKE EVPSQMKSIG SHDKKDPIHG VDIRTIIPFS GKGFVLGGNE
GRCSPGKSIN PSGSSKESSV VEVTQPVPKT SVTCEQDLSF ADRSFPRTSS MYSPLPKSSS
SFTSNSNFLP KKSVGNNKVF KNINGSPIKV SFKLNSSVET SGSQKKVNQY LTPLGVTKKR
VSSDLESSQQ HTFVSVQSTS SKRIDHKKKK MRTEETPRPI LDFFTKRSPQ GEQRDTINNY
AKSKANQEAT IPFQQDRDLG DLHVTVICPA CQSAVLESAI NVHLDSCLS
//
