ID H3BA35_LATCH Unreviewed; 1029 AA.
AC H3BA35;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Integrin subunit alpha 7 {ECO:0000313|Ensembl:ENSLACP00000018756.1};
GN Name=ITGA7 {ECO:0000313|Ensembl:ENSLACP00000018756.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000018756.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000018756.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; AFYH01034140; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01034141; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01034142; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01034143; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01034144; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01034145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01034146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01034147; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01034148; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01034149; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3BA35; -.
DR STRING; 7897.ENSLACP00000018756; -.
DR Ensembl; ENSLACT00000018889.1; ENSLACP00000018756.1; ENSLACG00000016510.1.
DR eggNOG; KOG3637; Eukaryota.
DR GeneTree; ENSGT00940000159891; -.
DR HOGENOM; CLU_004111_1_0_1; -.
DR InParanoid; H3BA35; -.
DR OMA; LHVSHDI; -.
DR TreeFam; TF105391; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000016510; Expressed in post-anal tail muscle and 4 other cell types or tissues.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF90; INTEGRIN ALPHA-7; 1.
DR Pfam; PF01839; FG-GAP; 1.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 3.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 3.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 969..997
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 185..240
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 241..302
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 356..417
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 402..565
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 567..734
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 740..957
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1029 AA; 114597 MW; B83EF274E2D9F454 CRC64;
ILVGAPQALA LANQQANRTG ALFSCPLTKE DDDCEQVEID GEVDLNKESK ENQWLGVTVK
SQGIGGKVVV CAHLYEFRQR VKQPSETRDV IGRCYVLSQD LTISDDLDGG DWKFCEGRPQ
GHQRFGFCQQ GISVSFTSDN HYILFGAPGT YNWKGNLRIE LFNHQTFDLN SYDDGPYEAG
GEKEQDPRLI PVPSNSYFGF SVDSGKGLTR KRELSFVAGA PRANHTGAVI ILKKDNVNRL
VPEYVLWGEE LASSFGYSVA VTDLNNDGWM DLIVGAPNFF DRKEEIGGGA YVYINQVGNW
NEVKPVRLNG TYHSMFGLVV ASIGDVNQDG YGGNASDILE LRLLAHCVCT VTATPQKKIL
DGEGVGVKKF GYSISGGLDI DENSYPDLVV GSLSDSVVLY RARPVTNITS EIKINPENID
LEQNTCRNSL GVCVDVRTCF NYNANPTTYK PRLTLGYMLE ADGERRKLGL APRVQFLRRK
HTDAEHQFSD SVELHAQGET KCATATFQLQ ENLRDKLRTI PVTLTYRIKH ARLRRQAKEE
LEPLMPVLNA QYPNSIRAEV NFLREGCGED KVCQSNLQLH YQFCSRVGSN TDTFTPLPLD
SNKMAVFSLT DQEDVALEIT VTNSPSDRRH PHRDGDDAHA AQLIASIPDT LTYSAFRSHQ
PVTDKQLVCA ANQNGSRVEC ELGNPMKRDA KVTFYLILST SGINIETTEL AVDLQLATIS
EQPDLEPVTA RASVVLELPL SVTGISPPFS ITYIYGGTLW GEQSQEQSPD SIPTVSFHFF
KVSNRGQSLK TLGSAFLNVM WPYEVSNGKW LLYPIRVHFE GNHRMQCAST HVVNQLKLRY
KQKKRRKREV ERMQVDNAGS ASGSAWPVAY SERKKTHILD CTLGTAKCVV FQCPLYSFDA
AAVLKIRSRL WNSTFLEDFS SVSSIELIVR ANITVKSSIK NLVLREAMTQ IQVTVYPDQE
TSEYTGIPWW IILIAILAGI LVNALVGIIL WFLCGFFKRT STESKFTAEY HKAQLAVQPS
EAEKQATEA
//
