ID H3BA40_LATCH Unreviewed; 629 AA.
AC H3BA40;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Melanoma cell adhesion molecule {ECO:0000313|Ensembl:ENSLACP00000018761.2};
GN Name=MCAM {ECO:0000313|Ensembl:ENSLACP00000018761.2};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000018761.2, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000018761.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01011785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01011786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01011787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01011788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01011789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01011790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01011791; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01011792; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3BA40; -.
DR Ensembl; ENSLACT00000018894.2; ENSLACP00000018761.2; ENSLACG00000016514.2.
DR GeneTree; ENSGT00940000155838; -.
DR HOGENOM; CLU_028888_3_0_1; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000016514; Expressed in pectoral fin and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00099; IgV; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR11973:SF18; CELL SURFACE GLYCOPROTEIN MUC18; 1.
DR PANTHER; PTHR11973; CELL SURFACE GLYCOPROTEIN MUC18-RELATED; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..629
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003581071"
FT TRANSMEM 543..567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..134
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 139..246
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 252..340
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 345..425
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 432..516
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 606..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..629
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 629 AA; 69723 MW; A3EE222B2A301976 CRC64;
MGIRERMAFS TTALCILLIT VQGISGEIKV FMLQVEEKEV GQPAQIECQA SISEPTTEVH
VQWFFLNGNK RERIYFMDSK HSVADNGTEY TGRISMDKNY TLTIHSVTLR DQGTFICQVG
AGAVGKNENR TELRVYDAPE LPEIKGEETG IAVTEESSIP KIAHCISRNG YPPPNITWYK
DQTPLQDQEG VTSVQATLTK ESSGLFSVES HLFHRVTKKD KDSKFYCEIN YQMPGINHMM
ESSKIGIILH YPMEQLKFLR VFPDGPIKEG DTVKFECRGD GNPPPEYSFY KNNQGIDVNP
AFDQGLLILE NVTQMSTGTY ECRGLDLETV TELNKEVNIT VNYLTNITLT PDGPLELAVG
EDKTLSCNAH ASALTAFQWE KSDMEVFTGG NSLHLTNVNY SSTGTYTCEV TVPTVPGLVK
SKSILITVSG KPEVTAPQNK LWVYIGEEVN LTCVAFGHPE AEITWNVAGN LTVRHRGDHT
VTSQLTVKVV PELLRLGITC NASNMMGSGQ QSFQLYQVLP TTHSTAKTDD IVRKKQKNPE
SSGVIIVAVI VCILLLAVLG ATLYFLYKKG KISCGRSGKQ DITRPEDQKD IIMELKTDKV
QEEAGLLQGA NGDKKPPRDQ GEQYIDLRN
//
