ID   H3BAL3_LATCH            Unreviewed;       965 AA.
AC   H3BAL3;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   RecName: Full=Importin-13 {ECO:0000256|ARBA:ARBA00016020};
GN   Name=IPO13 {ECO:0000313|Ensembl:ENSLACP00000018934.1};
OS   Latimeria chalumnae (Coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000018934.1, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Proteomes:UP000008672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT   "The draft genome of Latimeria chalumnae.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000018934.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBUNIT: Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.
CC       {ECO:0000256|ARBA:ARBA00011422}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the importin beta family.
CC       {ECO:0000256|ARBA:ARBA00007991}.
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DR   EMBL; AFYH01055529; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01055530; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01055531; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01055532; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01055533; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01055534; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01055535; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01055536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01055537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01055538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H3BAL3; -.
DR   STRING; 7897.ENSLACP00000018934; -.
DR   Ensembl; ENSLACT00000019067.1; ENSLACP00000018934.1; ENSLACG00000016657.1.
DR   eggNOG; KOG2022; Eukaryota.
DR   GeneTree; ENSGT00530000063347; -.
DR   HOGENOM; CLU_005996_3_0_1; -.
DR   InParanoid; H3BAL3; -.
DR   OMA; KYPAEMA; -.
DR   TreeFam; TF314539; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   Bgee; ENSLACG00000016657; Expressed in chordate pharynx and 2 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:UniProt.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040709; Importin_rep_1.
DR   InterPro; IPR040944; Importin_rep_2.
DR   InterPro; IPR040520; Importin_rep_3.
DR   PANTHER; PTHR12363:SF56; IMPORTIN-13; 1.
DR   PANTHER; PTHR12363; TRANSPORTIN 3 AND IMPORTIN 13; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   Pfam; PF18773; Importin_rep; 1.
DR   Pfam; PF18786; Importin_rep_2; 1.
DR   Pfam; PF18806; Importin_rep_3; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          41..107
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00913"
FT   REGION          623..642
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   965 AA;  109464 MW;  244DD7A7DF58C3CF CRC64;
     PRRRGRRLLP SFSNPFSPVF SLLQALHQLY YDPNIENKNL AQKWLMQAQV SPQAWHFSWL
     LLDPEKVPEI QYFGASALHL KISRYWGDIP TEQYGSLKSQ LFAQITRFSS GSKIVLTRLC
     VALASLALNM MPEAWPGAVS DMVRMFQTES SDADGRARCV ALLELLTVIP EEFQTSRLPQ
     YRKGQVRNAL GQESSAVFPL LEQLLTQEDS PTFIRQKVLK CFSSWVQLEI ALTECESLMH
     AAFSSLQDAD LFDTAVEAIV NTISQPDAQR YVNTLLKLIP RVLGLQEQLR QAVQSGDMET
     SHGICRIIVA LGENHSRALL EQMEHWESFL ALVNMIMYCT GIPGHYPVHE TTSSLTLTFW
     YSLQDDIMSF EAEKQAMYLH VYRPVYFQLV DVLLHKAQFP TDEEYGTWSS DEKEQFRIYR
     VDVSDTLMYV YEMLGAELLS NLYDKLGRLL TNTEQTASWQ HTEALLYGFQ SIAETIDVNY
     SDVIPGLIAL IPRININNVQ LADTVMFTIG ALAEWLADHP VMINNVLPLV LHALGNPDLS
     ISSVSTLKKI CRECKYDLPP YAANIVAVSQ QVTLKDVHCT SQCMWLMQAL GFLLSALQVE
     EILRNLHSLI SPYIQQLEKL ADETRNPPPK KKHTHIPSLL NQPVYPTAGE ARRRDTHPQK
     EQKKLHHFIK CSINPVVMVL QQVFQLIQKV LSKWLNDAQV VEAVCAIFEK SVKTLLDDFA
     PMVPQLSEML GQMYSTIPQA SALDLTRQDG SVHILQHMVF PLPPLPSFFP LVNYFSITLT
     IFLGPREHPD IVDSFMQLLA QALKRKSDLF LSDTLDVKAV FHCGIISLKF PEAPTVKASC
     NFFTELLPRC AEIPSVGQVV HENGKLLLQA VMEGIGGQTS RSLMDHLADI LFSLNKHCFS
     YLSVWIKEVM QQQGFPSSRV TAEQKETFSQ QILRERVNKR RVKEAVKEFT LLCRGLHGTE
     YAADY
//