ID H3BCG7_LATCH Unreviewed; 435 AA.
AC H3BCG7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial {ECO:0000256|ARBA:ARBA00019998};
GN Name=ECSIT {ECO:0000313|Ensembl:ENSLACP00000019588.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000019588.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000019588.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ECSIT family.
CC {ECO:0000256|ARBA:ARBA00007674}.
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DR EMBL; AFYH01054435; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01054436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01054437; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01054438; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01054439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005994181.1; XM_005994119.2.
DR AlphaFoldDB; H3BCG7; -.
DR STRING; 7897.ENSLACP00000019588; -.
DR Ensembl; ENSLACT00000019726.1; ENSLACP00000019588.1; ENSLACG00000017226.1.
DR GeneID; 102366266; -.
DR KEGG; lcm:102366266; -.
DR CTD; 51295; -.
DR eggNOG; KOG3941; Eukaryota.
DR GeneTree; ENSGT00390000005147; -.
DR HOGENOM; CLU_046917_0_0_1; -.
DR InParanoid; H3BCG7; -.
DR OMA; EEDFSHW; -.
DR OrthoDB; 4098911at2759; -.
DR TreeFam; TF314943; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000017226; Expressed in chordate pharynx and 6 other cell types or tissues.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR029342; ECIST_C.
DR InterPro; IPR010418; ECSIT.
DR InterPro; IPR046448; ECSIT_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR13113; ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYS; 1.
DR PANTHER; PTHR13113:SF1; EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL; 1.
DR Pfam; PF14784; ECSIT_C; 1.
DR Pfam; PF06239; ECSIT_N; 1.
DR SMART; SM01284; ECSIT_Cterm; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 282..407
FT /note="ECSIT C-terminal"
FT /evidence="ECO:0000259|SMART:SM01284"
FT REGION 57..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 435 AA; 49961 MW; AFD971EAE139B026 CRC64;
MSCSRSLVLA RGLGALPFAS RENIGASTQW PLTLIRKQLP RHQDCSVWLS RSFYTSPQAA
SSEPAPSAES KDQERGPRDK SLVTYDDLFK KAAGDSRTKA TFNRVVDTFC NKNVRRRGHV
EFIYAALKKM PEFGVERDIN IYNRILDVFP KEVFVPQNFI QRMFNHYPRQ QECGVQVLEQ
MENYGIMPNK ETKFLLVQIF GEKSHPVRKY QRIMYWFPKF KHANPYPVPA VLPQDPLDLA
KFSLQRIAAD LDAKTTVFQM PATDISEDGA EVKQPYVVGI QGPDQQDLLA KHNPDRPVFV
EGPFPLWLRQ TCVYYYILRA DPLPPEERVE EEMDSERNFY YPMVLDFDLD RDLGDYYDFD
VDDVEEGPIF SLCMTDSGDQ ITLGKWISGL QQTNPVLGCT PVVFRLDSGP QEIQTPTEAE
ATDDEDIIQN QKMKQ
//
