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Database: UniProt
Entry: H3BCI6_LATCH
LinkDB: H3BCI6_LATCH
Original site: H3BCI6_LATCH 
ID   H3BCI6_LATCH            Unreviewed;       760 AA.
AC   H3BCI6;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   24-JAN-2024, entry version 70.
DE   SubName: Full=Leucine-rich repeat and fibronectin type III domain-containing protein 1-like {ECO:0000313|Ensembl:ENSLACP00000019607.1};
GN   Name=LRFN1 {ECO:0000313|Ensembl:ENSLACP00000019607.1};
OS   Latimeria chalumnae (Coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000019607.1, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Proteomes:UP000008672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT   "The draft genome of Latimeria chalumnae.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000019607.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   EMBL; AFYH01009939; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005987901.1; XM_005987839.2.
DR   RefSeq; XP_005987902.1; XM_005987840.2.
DR   RefSeq; XP_005987903.1; XM_005987841.2.
DR   RefSeq; XP_005987904.1; XM_005987842.2.
DR   AlphaFoldDB; H3BCI6; -.
DR   STRING; 7897.ENSLACP00000019607; -.
DR   Ensembl; ENSLACT00000019745.1; ENSLACP00000019607.1; ENSLACG00000017241.1.
DR   GeneID; 102358820; -.
DR   KEGG; lcm:102358820; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   GeneTree; ENSGT00940000160922; -.
DR   HOGENOM; CLU_016998_0_1_1; -.
DR   InParanoid; H3BCI6; -.
DR   OMA; HQREALP; -.
DR   OrthoDB; 2942402at2759; -.
DR   TreeFam; TF350185; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   Bgee; ENSLACG00000017241; Expressed in chordate pharynx and 3 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR45842:SF18; LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR45842; SYNAPTIC ADHESION-LIKE MOLECULE SALM; 1.
DR   Pfam; PF00041; fn3; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF13855; LRR_8; 2.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00369; LRR_TYP; 6.
DR   SMART; SM00082; LRRCT; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS50853; FN3; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS51450; LRR; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..760
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003581155"
FT   TRANSMEM        523..549
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          289..377
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          416..511
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   REGION          389..416
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          723..742
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        391..416
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   760 AA;  85185 MW;  741BBF30F1F14342 CRC64;
     MERLVFCLLT LGVAVKAQSP NCPGRCICQN ISPTLTMLCA KTGLLFVPPT IDRQTVELRL
     TDNFITIIRK KDFVNMTNLV HLTLSRNTIS QIMPHAFIDL RSLRALHMDN NRLTALKSEH
     FKGLGNLRHL ILGNNQIHYI QQEAFDEFLG TVEDLDLSYN NLETLPWEAI GKMTNLNTLT
     LDHNLIDNIA EGTFSMLHKL VRLDMTSNQL QKLPPDNLFL RAQVLANARG SHPSTLAVSF
     GGNPLHCNCE LLWLRRLTRE DDLETCASPE HLMDKYFWSI EEEEFICEPP LIMRHCASKT
     FIMEGQGVIL KCKAVGDPDP SIHWISPDGK LIHNTTRTII YDNGTLEILI TTLKDNGFFT
     CIASNAAGET TAPVEVNIVP LPLLVNNTNH LREPDPGSSD ITTSTKSGSN DTKNQLEKKV
     LAGELTSSSV VIRWPSERHI PGIRMYQIQY NSSFDDALVY RMIPPTSKTF SVNDLAAGRD
     YDLCVLAVYD DGMTALTATR VVGCVQFTTE NENTQCQSIH TQFLGGTMII IIGGIIVASV
     LVFIIILMIR YKAYNSHDEH KAKVSNVYSQ TNGNQTGNLS HSASKVVEDK HEQVQRSPKT
     TTKDSTPVIL KVDCEKSNIP RSASIVSENM LPDKERNKRR TSIDLQTNIF LSSEEGQTEN
     SVAGSTMSLC LIGSSKEMPV WRDKQTKLGS IAILPRDIPR THHHRFSFDG DYSLFQSHSY
     PRRARTRRHM STSQLNSEDS PLGNKRVTFS STEWMLESTV
//
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