ID H3BCI6_LATCH Unreviewed; 760 AA.
AC H3BCI6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 70.
DE SubName: Full=Leucine-rich repeat and fibronectin type III domain-containing protein 1-like {ECO:0000313|Ensembl:ENSLACP00000019607.1};
GN Name=LRFN1 {ECO:0000313|Ensembl:ENSLACP00000019607.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000019607.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000019607.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR EMBL; AFYH01009939; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005987901.1; XM_005987839.2.
DR RefSeq; XP_005987902.1; XM_005987840.2.
DR RefSeq; XP_005987903.1; XM_005987841.2.
DR RefSeq; XP_005987904.1; XM_005987842.2.
DR AlphaFoldDB; H3BCI6; -.
DR STRING; 7897.ENSLACP00000019607; -.
DR Ensembl; ENSLACT00000019745.1; ENSLACP00000019607.1; ENSLACG00000017241.1.
DR GeneID; 102358820; -.
DR KEGG; lcm:102358820; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000160922; -.
DR HOGENOM; CLU_016998_0_1_1; -.
DR InParanoid; H3BCI6; -.
DR OMA; HQREALP; -.
DR OrthoDB; 2942402at2759; -.
DR TreeFam; TF350185; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000017241; Expressed in chordate pharynx and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45842:SF18; LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45842; SYNAPTIC ADHESION-LIKE MOLECULE SALM; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 6.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..760
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003581155"
FT TRANSMEM 523..549
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 289..377
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 416..511
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 389..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 723..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 760 AA; 85185 MW; 741BBF30F1F14342 CRC64;
MERLVFCLLT LGVAVKAQSP NCPGRCICQN ISPTLTMLCA KTGLLFVPPT IDRQTVELRL
TDNFITIIRK KDFVNMTNLV HLTLSRNTIS QIMPHAFIDL RSLRALHMDN NRLTALKSEH
FKGLGNLRHL ILGNNQIHYI QQEAFDEFLG TVEDLDLSYN NLETLPWEAI GKMTNLNTLT
LDHNLIDNIA EGTFSMLHKL VRLDMTSNQL QKLPPDNLFL RAQVLANARG SHPSTLAVSF
GGNPLHCNCE LLWLRRLTRE DDLETCASPE HLMDKYFWSI EEEEFICEPP LIMRHCASKT
FIMEGQGVIL KCKAVGDPDP SIHWISPDGK LIHNTTRTII YDNGTLEILI TTLKDNGFFT
CIASNAAGET TAPVEVNIVP LPLLVNNTNH LREPDPGSSD ITTSTKSGSN DTKNQLEKKV
LAGELTSSSV VIRWPSERHI PGIRMYQIQY NSSFDDALVY RMIPPTSKTF SVNDLAAGRD
YDLCVLAVYD DGMTALTATR VVGCVQFTTE NENTQCQSIH TQFLGGTMII IIGGIIVASV
LVFIIILMIR YKAYNSHDEH KAKVSNVYSQ TNGNQTGNLS HSASKVVEDK HEQVQRSPKT
TTKDSTPVIL KVDCEKSNIP RSASIVSENM LPDKERNKRR TSIDLQTNIF LSSEEGQTEN
SVAGSTMSLC LIGSSKEMPV WRDKQTKLGS IAILPRDIPR THHHRFSFDG DYSLFQSHSY
PRRARTRRHM STSQLNSEDS PLGNKRVTFS STEWMLESTV
//