ID H3BD84_LATCH Unreviewed; 718 AA.
AC H3BD84;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Exostosin glycosyltransferase 2 {ECO:0000313|Ensembl:ENSLACP00000019855.1};
GN Name=EXT2 {ECO:0000313|Ensembl:ENSLACP00000019855.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000019855.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000019855.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004648}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 47 family.
CC {ECO:0000256|ARBA:ARBA00010271}.
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DR EMBL; AFYH01004930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01004931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01004932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01004933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01004934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01004935; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01004936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01004937; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01004938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01004939; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005986973.1; XM_005986911.2.
DR RefSeq; XP_005986974.1; XM_005986912.2.
DR STRING; 7897.ENSLACP00000022395; -.
DR Ensembl; ENSLACT00000019993.1; ENSLACP00000019855.1; ENSLACG00000017456.2.
DR Ensembl; ENSLACT00000025500.1; ENSLACP00000022395.1; ENSLACG00000017456.2.
DR GeneID; 102363354; -.
DR KEGG; lcm:102363354; -.
DR CTD; 2132; -.
DR eggNOG; KOG1022; Eukaryota.
DR GeneTree; ENSGT00940000156620; -.
DR HOGENOM; CLU_013906_4_1_1; -.
DR OMA; NCTFWDC; -.
DR OrthoDB; 1220028at2759; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000017456; Expressed in pelvic fin and 6 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0006486; P:protein glycosylation; IEA:InterPro.
DR InterPro; IPR004263; Exostosin.
DR InterPro; IPR040911; Exostosin_GT47.
DR InterPro; IPR015338; GT64.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR48261; ACETYLGLUCOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR48261:SF2; EXOSTOSIN-1-LIKE; 1.
DR Pfam; PF03016; Exostosin; 1.
DR Pfam; PF09258; Glyco_transf_64; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 101..380
FT /note="Exostosin GT47"
FT /evidence="ECO:0000259|Pfam:PF03016"
FT DOMAIN 456..701
FT /note="Glycosyl transferase 64"
FT /evidence="ECO:0000259|Pfam:PF09258"
SQ SEQUENCE 718 AA; 82053 MW; 1150C94D7F4E29B4 CRC64;
MCASVKYGGR GPALIPRMKT KYRIYYIALF SVVLLGLIAT GVFQFWPHSI ESSSDWTVEK
RSVHDVPVFK LPADSPIPER GDLSCRMHTC FDVYRCGYNP KNKIKVYIYP LRKYVDEYGT
PISNTISKEY NELLTAISES EFYTDDITRA CLFVPSIDVL NQNTLRIKET AQALAQLSRW
DRGTNHLLFN MLPGGPPDYN TALDVPRDRA LLAGGGFSTW TYRQGYDVSI PVYSPFSAEL
EFPEKPPGPR TYFLLSTQTA VHPEYLSELE AIKVEMGESV LILDKCSNLS DGVPSIQKRC
YKGHVFDYPQ ILQEATYCVV LRGARLGQVV LSDILQAGCV PVVVADSYVL PFSEVLDWKR
ASVVVPEEKL SEVHNILKNI PSRQVEEMQK QARWFWEAYF KSMKVIAMAT LQIINDRIYP
YAARSYEEWN DPPAVKWSSV SNPLFLPLIP PRSQGFTAVI LTYDRVESLF RVITEISKVP
SLSKLLVVWN NQNKNPPEES AWPKTGVPLK VVKTKENKLS NRFFPYDEIE TEAVLAIDDD
IIMLTSDELQ FGYEVWREFP DRLVGYPGRL HLWDHEVGKW KYESEWTNEV SMVLTGAAFY
HKYFNYLYTY KMPGDIKSWV DDHMNCEDIA MNFLVANVTG KPPIKVTPRK KFKCPECTAI
DGLSLDQTHM VERSECINKF ASVFGTMPLK VVEHRADPVL YKDDFPEKLK SFPNIGSL
//
