ID H3BD92_LATCH Unreviewed; 786 AA.
AC H3BD92;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Heterogeneous nuclear ribonucleoprotein U {ECO:0000313|Ensembl:ENSLACP00000019863.1};
GN Name=HNRNPU {ECO:0000313|Ensembl:ENSLACP00000019863.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000019863.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000019863.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AFYH01043546; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01043547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01043548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01043549; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01043550; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01043551; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01043552; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01043553; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3BD92; -.
DR STRING; 7897.ENSLACP00000019863; -.
DR Ensembl; ENSLACT00000020001.1; ENSLACP00000019863.1; ENSLACG00000017463.1.
DR eggNOG; KOG2242; Eukaryota.
DR GeneTree; ENSGT00940000156546; -.
DR HOGENOM; CLU_012140_1_0_1; -.
DR InParanoid; H3BD92; -.
DR OMA; PHQFQQR; -.
DR TreeFam; TF317301; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000017463; Expressed in pectoral fin and 6 other cell types or tissues.
DR CDD; cd12884; SPRY_hnRNP; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.720.30; SAP domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR036361; SAP_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035778; SPRY_hnRNP_U.
DR PANTHER; PTHR12381:SF11; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U; 1.
DR PANTHER; PTHR12381; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER; 1.
DR Pfam; PF13671; AAA_33; 1.
DR Pfam; PF02037; SAP; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00513; SAP; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF68906; SAP domain; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50800; SAP; 1.
PE 4: Predicted;
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 8..42
FT /note="SAP"
FT /evidence="ECO:0000259|PROSITE:PS50800"
FT DOMAIN 245..441
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 41..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 649..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..101
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..157
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..253
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 786 AA; 87423 MW; 5C922BBFCCDF5914 CRC64;
KMSSPINVKK LKVSELKEEL KKRRLSDKGL KAELMERLQE ALDEEQEASG AALLQQDNGV
GAEVGGEAEE SGHGEEEEEE EPDEEEAVDQ SETVGEDMEQ EAADLNGEKP AASGERVEAA
AAAAEHENGE DGGYQEGDEE MGEEDELEEE EEAGAGGREE ESDSTEQKAS EPQAAEGEVQ
TIVSQSRACV RARVSSTARA AADERKEGEA KAEQKAGDKK RGVKRPRDDH GRGYFEYIEE
NKYSRAKSPQ PPVDEEDEEL DDTVVCLDTY NCDLHFKISR DRLSASPLTM ESFAFLWAGG
RATYGVSKGK VCFEMKVAEK IPVKHLHKKE IDIHEVRVGW SLESNGMLLG DEEFSYGYSL
KGMKATNGVM EDYGEKFDEN DVIGCFANFE GDEVELSYTK NGQNLSVAFK VSKEALAGKA
LFPHVLCHNC AIEFNFGQNK TPYFPVPEEY TFIQQVPVED RFRGPKGPET KKECEVIMMV
GLPGAGKTTW VSKYVEENPG KYTVLGTNTV MDKMIVASFK HQMVQTGKLS TLFQRAPQCL
GKFIEIAARK KRNFILDQTN VSSAAQRRKL CLFAGFKRKA VVVCPTDEDY KQRTQKKAET
EGKDLPEHAL LKMKGSFIFK VLLQPPPTPT HAEVKRNRIS NTIKFYKTTS EHANVQRPKG
NAGKTKGKVE KPKAKTQKSV GGSLGPVNRG GFNSGGFNRR GGNMPQRGFP FNRGIGFVNR
GGFPNRGNFN RGGGGMPQRG NFNQNFRGRG NNRGFKNNSQ GYNQWQHQGQ FWGQKPWTQH
YHQGYY
//
