ID H3BDM8_LATCH Unreviewed; 737 AA.
AC H3BDM8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Adaptor related protein complex 2 subunit alpha 1 {ECO:0000313|Ensembl:ENSLACP00000019999.1};
GN Name=AP2A1 {ECO:0000313|Ensembl:ENSLACP00000019999.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000019999.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000019999.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC {ECO:0000256|ARBA:ARBA00006613}.
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DR EMBL; AFYH01030540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01030541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01030542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01030543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01030544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01030545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3BDM8; -.
DR STRING; 7897.ENSLACP00000019999; -.
DR Ensembl; ENSLACT00000020137.1; ENSLACP00000019999.1; ENSLACG00000017580.1.
DR eggNOG; KOG1077; Eukaryota.
DR GeneTree; ENSGT00950000182838; -.
DR HOGENOM; CLU_003824_1_2_1; -.
DR InParanoid; H3BDM8; -.
DR OMA; ILYEDQY; -.
DR TreeFam; TF300308; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000017580; Expressed in pelvic fin and 3 other cell types or tissues.
DR GO; GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProt.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 2.60.40.1230; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.30.310.10; TATA-Binding Protein; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR InterPro; IPR003164; Clathrin_a-adaptin_app_sub_C.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR009028; Coatomer/calthrin_app_sub_C.
DR InterPro; IPR012295; TBP_dom_sf.
DR PANTHER; PTHR22780; ADAPTIN, ALPHA/GAMMA/EPSILON; 1.
DR PANTHER; PTHR22780:SF33; AP-2 COMPLEX SUBUNIT ALPHA-1; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR Pfam; PF02296; Alpha_adaptin_C; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR SUPFAM; SSF55711; Subdomain of clathrin and coatomer appendage domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 501..618
FT /note="Clathrin adaptor alpha/beta/gamma-adaptin appendage
FT Ig-like subdomain"
FT /evidence="ECO:0000259|SMART:SM00809"
SQ SEQUENCE 737 AA; 81903 MW; 55FFF635918F47A8 CRC64;
IHVCVLYLTT VYVVLEDAAV KGRLVECLET ILNKAQEPPK SKKIQHSNAK NAILFEAISL
IIHYDSEPNL LVRACNQLGQ FLQHRETNLR YLALESMCTL ASSEFSHEAV KTHIETVINA
LKTERDVSVR QRAADLLYAM CDRTNSKQIV SEMLSYLETA DYSIREEIVL KVAILAEKYA
VDYTWYVDTI LNLIRIAGDY VSEEVWYRVI QIVINRDDVQ GYAAKTVFEA LQAPACHENM
VKVGGYILGE FGNLIAGDPR SSPLVQFNLL HSKFHLCSVP TRALLLSTYI KFINLFPETK
PTIQEVLRSD SQIRNADVEL QQRAVEYLKL SSIASTDVLA TVLEEMPPFP ERESSILAKL
KKKKGPGGVV VDVEEGKKET NSEINGGGAE VTSTAYIGTI SASRDLFGLS STPVGDLEPA
SNTSASLLVD AEPSHFVLSA LGFLLPGFPR NSQCVYTHIY IYIEVLPSNP PLKLLVDFSN
TAAPTSEDPA LPVPEADELL NKFVCKNNGV LFENQLLQLG VKSEFRQNLG RIYLFYGNKT
SVQFLSFATT VTCPGDLQTH LNIQTKEVDP VVEGGAQVQQ VINIECLSDF TEAPLINIKF
SLCARYGGAL QNITLKLPVT VNKFFQATEM TSQDFFQRWK QLSLPQQEAQ KIFKANHPMD
SEVTKAKLIG FGSALLENVD PNPDNFVGAG IIQTKSVQVG CLLRLEPNAQ AQMYRLTLRT
SKESVSRNLC ELLSKQF
//
