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Database: UniProt
Entry: H3BE87_LATCH
LinkDB: H3BE87_LATCH
Original site: H3BE87_LATCH 
ID   H3BE87_LATCH            Unreviewed;       486 AA.
AC   H3BE87;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   08-MAY-2019, entry version 33.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
GN   Name=HYAL2 {ECO:0000313|Ensembl:ENSLACP00000020208};
OS   Latimeria chalumnae (Coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000020208, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Ensembl:ENSLACP00000020208}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000020208};
RX   PubMed=9215903;
RA   Zardoya R., Meyer A.;
RT   "The complete DNA sequence of the mitochondrial genome of a 'living
RT   fossil,' the coelacanth (Latimeria chalumnae).";
RL   Genetics 146:995-1010(1997).
RN   [2] {ECO:0000313|Proteomes:UP000008672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT   "The draft genome of Latimeria chalumnae.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSLACP00000020208}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713}.
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DR   EMBL; AFYH01005809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01005810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01005811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7897.ENSLACP00000020208; -.
DR   Ensembl; ENSLACT00000020348; ENSLACP00000020208; ENSLACG00000017761.
DR   eggNOG; ENOG410IECJ; Eukaryota.
DR   eggNOG; ENOG410XPZT; LUCA.
DR   GeneTree; ENSGT00950000182708; -.
DR   InParanoid; H3BE87; -.
DR   OMA; GGEQCQW; -.
DR   TreeFam; TF321598; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PIRSF; PIRSF038193; Hyaluronidase; 1.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008672};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT   ACT_SITE    152    152       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR038193-1}.
FT   CARBOHYD    374    374       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000256|PIRSR:PIRSR038193-2}.
FT   DISULFID     63    357       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    228    244       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    382    393       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    387    444       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    446    455       {ECO:0000256|PIRSR:PIRSR038193-3}.
SQ   SEQUENCE   486 AA;  55660 MW;  E5917BE7559018D0 CRC64;
     QAPASHSTLV VVGEMFPRTL LTALYLLTLL FANACCQHLK QTSPPIFTHK PFIVVWNAPT
     QDCKPRYKVE LDVSMFDVAA SPNEGFVDQK LTIFYKERLG LYPYYSSDRR DPINGGLPQN
     GSIEDHLGKL QESINKYIRS ANIEGLAVID WEEWRPLWIR NWHTKDIYRN LSNKLVAEKH
     SSWSVESVAK QAQYDFENSA KDFMLRTLQE VKNLRPMQLW GYYLFPDCYN HDYKTNLQNY
     TGSCPDVEQS RNDQLFWLWQ ESTALYPSIY LDSKLASSPN SRRFVRARVK EAMRISNLHH
     QNYSLPVFVY TRPTYTYMVE ELSQMDLEHT IGESAALGAA GAIVWGDNDY GKSAENCQKI
     KDYLKTKMGH YILNVSTAAH HCSNILCMGN GRCRRKDSNS DTYLHLSPGS FRIQSLGLNG
     RERLTAIGKP SLRDIEEFQK GFQCQCYRGW LGPACKDPDT SGAQAARRQL PDFLLLLGLS
     LLVILF
//
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