ID H3BEA7_LATCH Unreviewed; 502 AA.
AC H3BEA7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=RAR related orphan receptor C {ECO:0000313|Ensembl:ENSLACP00000020228.1};
GN Name=RORC {ECO:0000313|Ensembl:ENSLACP00000020228.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000020228.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000020228.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000256|RuleBase:RU004334}.
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DR EMBL; AFYH01036417; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01036418; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01036419; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01036420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01036421; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01036422; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01036423; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01036424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01036425; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01036426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3BEA7; -.
DR STRING; 7897.ENSLACP00000020228; -.
DR Ensembl; ENSLACT00000020368.1; ENSLACP00000020228.1; ENSLACG00000017778.1.
DR eggNOG; KOG4216; Eukaryota.
DR GeneTree; ENSGT00940000161521; -.
DR HOGENOM; CLU_007368_2_0_1; -.
DR InParanoid; H3BEA7; -.
DR OMA; RTHIHRH; -.
DR TreeFam; TF319910; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06968; NR_DBD_ROR; 1.
DR CDD; cd06939; NR_LBD_ROR_like; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR044101; NR_DBD_ROR.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR003079; ROR_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR45805; NUCLEAR HORMONE RECEPTOR HR3-RELATED; 1.
DR PANTHER; PTHR45805:SF1; NUCLEAR RECEPTOR ROR-GAMMA; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR01293; RORNUCRECPTR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 6..81
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 253..490
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 121..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 502 AA; 57442 MW; 991CED4C3E03CC8B CRC64;
MSQIEVIPCK ICGDKSSGIH YGVITCEGCK GFFRRSQQSN VTYSCSRQKN CQIDRTSRNR
CQHCRLQKCL TLGMSRDAVK FGRMSKKQRD SLYTEVQKHR LQQQQQQLQL QGSPGEAEAL
AYNTGLPNGQ GRLASSSSSP NEAEAAAFSP YLPNGESRMG ESPGEAKAED YTKGLTRIPE
DHFIKGDCLK RLKPEARGDG FYSFEVQSSP DQSERDINGI KRSDVHDFAD TIDFYTSQNF
SSMLEATPST LAEIDQLTQN IIRSHRETCQ YRLEDLHTLR WKTFSREDVY SYQRTSMEEM
WERCACRITD AIQYIVEFAK RVHGFMELCQ NDQIVLLKAG SMEVVFVRMC RAFNPENNTI
FFEGNYAGPE VFKSLGCSDL VTAVFDFSRG MCSLHLSEQE IALFTARVLI SADRQWLQEK
FKVERLQSNV EHAFKQLLQK NHRQGIHTKL LSKVANLRTL CSQHIEKLRG FRQMYPLIVH
SLFPPLYKEL FASEVETQSS TE
//
