ID H3BEZ4_LATCH Unreviewed; 485 AA.
AC H3BEZ4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Suppressor of cytokine signaling 7 {ECO:0000313|Ensembl:ENSLACP00000020465.1};
GN Name=SOCS7 {ECO:0000313|Ensembl:ENSLACP00000020465.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000020465.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000020465.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AFYH01023264; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01023265; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01023266; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01023267; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01023268; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01023269; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01023270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01023271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01023272; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01023273; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3BEZ4; -.
DR STRING; 7897.ENSLACP00000020465; -.
DR Ensembl; ENSLACT00000020605.1; ENSLACP00000020465.1; ENSLACG00000017987.1.
DR eggNOG; KOG4566; Eukaryota.
DR GeneTree; ENSGT00940000156314; -.
DR HOGENOM; CLU_022661_0_0_1; -.
DR InParanoid; H3BEZ4; -.
DR OMA; RGSCSTH; -.
DR TreeFam; TF321368; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10388; SH2_SOCS7; 1.
DR CDD; cd03741; SOCS_SOCS7; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035866; SOCS7_SH2.
DR InterPro; IPR037346; SOCS7_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF5; SUPPRESSOR OF CYTOKINE-SIGNALING 7; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 304..413
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 408..458
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 197..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..217
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 485 AA; 54168 MW; 5F2FA78ACFF020CE CRC64;
DDPAETSDAL LVLEGLESEA DSMDTNSCSE EDFNSPCRGF WINGKNELQK PAASLELPPP
PFPLQDFTKP RVGRCASSPG CMAASAVTVA SAFAAAVKDN DPKSSRPLKS RKGSLKIRLS
KLFRTRSCSS SNEAVEKRHS VDLPTSAGSL TDMCGSNDRV TDLGRKPRLT RTQSAFSPVS
FTPVFTGETV SLVDVDISRR GPPSAHPPTP PPPPRRSLSL LDDINGSQLG SVLVSPVGSS
LQSLPLPPPP PPHAPIFHQA FPRVGETQPA QTLSQPNQQL HVPLSRQDSN SFAASLRELE
KCGWYWGPMN WEDAEMKLKG KPDGSFLVRD SSDPRYILSL SFRSQGITHH TRMEHYRGTF
SLWCHPKFED RCQSVVEFIE RAIMHSKHGK FLYFLRSRVP GLPPTPVQLL YPVSRFSNVK
SLQHLCRFRI RQLVRIDHIP ELPLPKPLIS YLRKFYYYDP EEEMYLSLKE ARQRLKQEVD
SEAQT
//
