ID H3BFJ6_LATCH Unreviewed; 608 AA.
AC H3BFJ6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 26 {ECO:0000256|ARBA:ARBA00019686};
DE AltName: Full=Cofactor required for Sp1 transcriptional activation subunit 7 {ECO:0000256|ARBA:ARBA00030125};
DE AltName: Full=Mediator complex subunit 26 {ECO:0000256|ARBA:ARBA00031968};
GN Name=MED26 {ECO:0000313|Ensembl:ENSLACP00000020667.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000020667.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000020667.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00649}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 26 family.
CC {ECO:0000256|ARBA:ARBA00009681}.
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DR EMBL; AFYH01022123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01022124; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01022125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01022126; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3BFJ6; -.
DR STRING; 7897.ENSLACP00000020667; -.
DR Ensembl; ENSLACT00000020807.1; ENSLACP00000020667.1; ENSLACG00000018158.1.
DR eggNOG; KOG1105; Eukaryota.
DR GeneTree; ENSGT00390000000259; -.
DR HOGENOM; CLU_478915_0_0_1; -.
DR InParanoid; H3BFJ6; -.
DR OMA; DPQSNIH; -.
DR TreeFam; TF328436; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000018158; Expressed in chordate pharynx and 6 other cell types or tissues.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00183; TFIIS_I; 1.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR042376; MED26.
DR InterPro; IPR031416; Med26_C.
DR InterPro; IPR031417; Med26_Mid.
DR InterPro; IPR003617; TFIIS/CRSP70_N_sub.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR PANTHER; PTHR15201; CRSP70; 1.
DR PANTHER; PTHR15201:SF1; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 26; 1.
DR Pfam; PF08711; Med26; 1.
DR Pfam; PF15693; Med26_C; 1.
DR Pfam; PF15694; Med26_M; 1.
DR SMART; SM00509; TFS2N; 1.
DR SUPFAM; SSF47676; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00649}; Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 1..77
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51319"
FT REGION 79..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..152
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 608 AA; 66664 MW; B2A25E27085CA1C3 CRC64;
MKDRLLQAID TQSNIRNMVA VLEVISSLEK YPITKEALEE TRLGKLINDV RKKTTNEDLA
KRAKKLLRNW QKLIEPVGQN EPVSKGLPNV PGSANGGAHN CKQEAPPPTA AVGLKPIQEL
KSRNDIQNLN SPKVEKLGNR KRKGEQRDGH PGPPSKIPKA TYEQIKNSSP PPTNGIGGSP
ENFPSPLGVT TVNAHTTSEK SRPENHENDK HSKIPVNAVK PHTSSPGLVK PPSTSSLLKT
AVLQQHEKLA LEASVGHCPP RSPRCVSYSP RNLKQEAAAK RPTTCAPKGA VSSPSVSSQV
LDIAPIPSPL PLAQPSTPPI LAKRPEAPLQ LESDESQLSM GQVATESHQH NVVGTALQQL
PLHGSRVSPH RDPTTTQHSL GFASDSSKVD SDDAASASDN KKKKKYRPRD YTVNLDGQLI
EGSVKPVRLK ERKLTFDPMT GQIKPLTHKD SVQVESPAPC EQFRTEPDRQ ETKANLPSPF
EQTNWKEISK NEIIQTYLNR QSSLLSSSGV QTPGAHYFMS EYLKQEESTR REAKKTAVLV
PNSSPTDLPG VSREVKGDDL DRIHDQHWPG VNGCFDTQGN WFDWTQCISL DPHGDDGRLN
ILPYVCLD
//
