ID H3BFZ5_LATCH Unreviewed; 1491 AA.
AC H3BFZ5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Rap guanine nucleotide exchange factor 6 {ECO:0000313|Ensembl:ENSLACP00000020816.1};
GN Name=RAPGEF6 {ECO:0000313|Ensembl:ENSLACP00000020816.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000020816.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000020816.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC -!- SIMILARITY: Belongs to the RAPGEF2 family.
CC {ECO:0000256|ARBA:ARBA00010829}.
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DR EMBL; AFYH01018876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01018877; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01018878; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01018879; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01018880; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01018881; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01018882; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01018883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01018884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01018885; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7897.ENSLACP00000020816; -.
DR Ensembl; ENSLACT00000020956.1; ENSLACP00000020816.1; ENSLACG00000018286.1.
DR eggNOG; KOG3542; Eukaryota.
DR GeneTree; ENSGT00940000158124; -.
DR HOGENOM; CLU_002782_0_1_1; -.
DR InParanoid; H3BFZ5; -.
DR OMA; GTCEYEF; -.
DR TreeFam; TF313184; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01785; RA_PDZ-GEF1; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45161; CYTOSKELETON-ASSOCIATED PROTEIN 4; 1.
DR PANTHER; PTHR45161:SF4; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1491
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003581264"
FT DOMAIN 152..252
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 284..397
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 402..472
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 623..709
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 734..961
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1026..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1101..1160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1176..1204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1301..1335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1350..1400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1470..1491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1110..1160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1176..1191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1308..1322
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1491 AA; 166466 MW; CCA45E7FD84C9879 CRC64;
RGFFFFFFKN LFCSSATSCV INGYPNRSFC VKVFLLQLPA DLTKMHLTDN PHPQVTHVPS
SQSGCSIASD SGSSSLSDIY QATESEIGDV DLTGLPEAAV DSEEEEEDED IDRPHDPLLG
RDVVRECLEK EPADRTDDDI ERLLEFMHQL PAFANMTMSV RRELCSMMIF EVVENAGATI
LEDGKELDSW YVVVNGSVEI THSDGRSESL CMGNSFGISP SLDKQYMSGV VRTKVDDCQF
VCIAQQDYWR ILNHVEKNTH KVEEEGEIVM VKEHRELDRS GTRKGHIVIK GTPEHLIKHL
VEEHSVVDPT YIEDFLLTYR TFLSSPLEVG KKLLEWFKSD SFRDKVTRVV LLWVNNHFND
FEGDPAMTQF LEEFENHLDI AKMKGHLRLL NIACAAKAKW RQVTLLKPFR ESPLCFTLLG
GSERGFGMFV ESVEQGSKAA EAGLKRGDQI MEVNGQNFEN ITNAKAMEIL RNNTHLSITV
KTNIFVFKEL LNRIMQEKKN GAPHIPKIAE KKGNRYSIPD LPGDVEQMFP CEKGNKKIKA
NTVSGGRNKI RKILDKTRFS ILPPKPFSDG GVGQSQDDSI VGTRQCRHSV AIMPIPGTLS
SSSPDLLQPV TNILDFSNPA DIPDQVIRVF KADQQSCYII ISKDTTAKDV VTHAIHEFGL
TAAPETYSLC EVSISPEGVI KQRRLPDQLS KLADRIQLNG RYYLKNNMET ETLCSDEDAQ
ELLRESQISL LQLSTVEVAT QLSMRDFELF RNIEATEYID DLFKLDSKTG TIHLKQFEDV
INQETFWVAT EILKEPNQIK RMKTVKHFIK IALHCRECKN FNSMFAVISG LNLAPVARLR
GTWEKLPSKY EKLLRDLQDM FDPSRNMTKY RSVLSSQSMQ PPIIPLFPVV KKDFTFLHEG
NDSKVEGLVN FEKLRMIAKE IRHVIRMTSA NMDPAVMFRH RKKRWRSLGS LSQGSTNSNM
LDVQGGAHKK RVRRSSLLNA KKLYEDAQMA RKVKQYLCNL NVETDEEKFQ IMSLQCEPAY
STLTKNLSDR RSAKSSDMSP VSMRSASQAS KSHQQPQHRM SQVLQVPAVN LHPNRKKGQT
KEHIPFSTSS PQFFKKTLAM SEDATGKKQA DDTISTASSL HSSPPASPQG SPRKGYASTP
ATKSDNFSDS SHSEISSRSS IVSNCSVDSV SAALQDERCP SQPLSATDSA GATERKQRRT
KFNPQNALCA SDVSVARPAG VRGSTVTSSM SNEEFCHEHT SLDAGDSGRG SWTSCSSSSH
DNIQTIQGQK GMDLLNSYRH LQLDGPIAEV EAANSWEEAS DCCPEELSNS NRHSKDSLEL
DRSRQSWASS SSLSDTYETN YGTIKRRAAD GSVAGPAEVS DLPPSADASY KTVTSSTEKG
LIAPKDDRYR EPPPTPPGYV GIPLVEIKEG SSHHPRLKPP DYSVAVRKSK MVPSQCDLSR
LSAASVASHP MACTPSKILA QPQWQNLQEP GPRLAIMTDS EEDEDEQVSA V
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