ID H3BGC0_LATCH Unreviewed; 1112 AA.
AC H3BGC0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Paxillin {ECO:0000256|ARBA:ARBA00023808};
GN Name=PXN {ECO:0000313|Ensembl:ENSLACP00000020941.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000020941.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000020941.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; AFYH01006526; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01006527; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01006528; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01006529; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01006530; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01006531; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01006532; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01006533; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01006534; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01006535; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3BGC0; -.
DR STRING; 7897.ENSLACP00000020941; -.
DR Ensembl; ENSLACT00000021081.1; ENSLACP00000020941.1; ENSLACG00000018399.2.
DR eggNOG; KOG1703; Eukaryota.
DR GeneTree; ENSGT00940000158897; -.
DR HOGENOM; CLU_007761_0_0_1; -.
DR InParanoid; H3BGC0; -.
DR OMA; SRAPPCH; -.
DR TreeFam; TF314113; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000018399; Expressed in post-anal tail muscle and 6 other cell types or tissues.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd09336; LIM1_Paxillin_like; 1.
DR CDD; cd09407; LIM2_Paxillin; 1.
DR CDD; cd09338; LIM3_Paxillin_like; 1.
DR CDD; cd09411; LIM4_Paxillin; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 4.
DR InterPro; IPR047072; Paxillin_Lim_dom2.
DR InterPro; IPR001904; Paxillin_Lim_dom4.
DR InterPro; IPR047075; Paxillin_TGFB1I1_LIM_dom1.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24216; PAXILLIN-RELATED; 1.
DR PANTHER; PTHR24216:SF8; PAXILLIN-RELATED; 1.
DR Pfam; PF00412; LIM; 4.
DR Pfam; PF03535; Paxillin; 1.
DR PRINTS; PR00832; PAXILLIN.
DR SMART; SM00132; LIM; 4.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 5.
DR PROSITE; PS00478; LIM_DOMAIN_1; 3.
DR PROSITE; PS50023; LIM_DOMAIN_2; 4.
PE 4: Predicted;
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 877..936
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 937..994
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 995..1054
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 1055..1112
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT REGION 18..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..576
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 732..808
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1112 AA; 122021 MW; 4DFF805084FCD775 CRC64;
LDALLADLES TTSHISKRPV FLPEETPYSY PTGGNTYQEI AVPPPVPPPP SSEALNGTVP
LDPKPQSQNF SPSVKNSSPS IIRETVSPPA AQTGEEEHVY SFPNKQKPTD PSSSAMSSSL
GSNLSELDRL LQELNCVQHN PPAGFSTEDS NRSPPQPTGL SSQYSTQENG GSLGRKVPPP
TKEKPKRNGS RGIEDVRPSV ESLLDQLESS VPTPTPAPAV SQVDVATPQR GTLSQEQARI
SASSATRELD ELMASLSDFK VQSNLSSLAS LNSEISLELQ KLSPELPLDK PTSVPCDTSA
QLDPSLSTGP QEAGRDSPPP HTPSPLELLH IEEDTTTTTR FSPTLPNPPS TPQVTQPLLH
QTCFAVSASH AQHTVSVSSR EKNTDSVNGV SPATLFSKVE LMEPKVQDLV SAEAVVKHEQ
NLETTLVITE VKQAMTSSIA TTQVELQVEN KLLGKAETKQ TMESISQRES EIDEALNKLL
TMEPETVKET CSKNEQVKEV HEVEIVAVDR KGKFPDTMGQ SSPVMLEMIN EEPQEKEEGV
LSLSVNYEKL EPAKYMPQKQ ERRATPDQET LRESPESHLS PGDQLESFPI VQPLVVERIS
ASRQMKSVIK RTKATSNVHP MYREDLPRRK LGPAIFHKTA SQDRLIEELH GKLGIGKTEQ
WNPSCPEDWL TEGVVVTSKP QRKREMGKQD VQKIIIPPES PVPQRRPFPV PASPPLKQHE
EIKKIIPQNV FPQSLPLPPP PPPPPPPQAP APLPTPPPLP LQAPVLPPTP PPVPPPPKIP
SPPAPSPVSQ PPMQLRSPPL PQAPGLVKPP PLKTMVTIGC QTDYDPLFPP MQFMAQGKAG
GVSPPSGPPK AGSQLDSMLG SLQSDLNKLG VATVAKGVCG ACKKPIAGQV VTAMGRTWHP
EHFVCTHCQE EIGSRNFFER DGQPYCEKDY HNLFSPRCYY CNGPILDRVV TALDRTWHPE
HFFCAQCGVF FGPEGFHEKD GKAYCRKDYF DMFAPKCGGC ARAILENYIS ALNSLWHPEC
FVCRQCFTPF INGSFFEHDG QPYCEMHYHE RRGSLCSGCQ KPITGRCITA MGKKFHPEHF
VCAFCLKQLN KGTFKEQNDK PYCQSCFLKL FC
//
