ID H3BH88_LATCH Unreviewed; 760 AA.
AC H3BH88;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Proprotein convertase subtilisin/kexin type 7 {ECO:0000313|Ensembl:ENSLACP00000021259.1};
GN Name=PCSK7 {ECO:0000313|Ensembl:ENSLACP00000021259.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000021259.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000021259.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01240}.
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DR EMBL; AFYH01007180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01007181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01007182; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01007183; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01007184; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01007185; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01007186; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01007187; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01007188; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01007189; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3BH88; -.
DR STRING; 7897.ENSLACP00000021259; -.
DR Ensembl; ENSLACT00000021400.1; ENSLACP00000021259.1; ENSLACG00000018680.1.
DR eggNOG; KOG3525; Eukaryota.
DR GeneTree; ENSGT00940000157676; -.
DR HOGENOM; CLU_002976_4_3_1; -.
DR InParanoid; H3BH88; -.
DR OMA; NGRMPFY; -.
DR TreeFam; TF314277; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000018680; Expressed in pectoral fin and 1 other cell type or tissue.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.70.850; Peptidase S8, pro-domain; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR032815; S8_pro-domain.
DR InterPro; IPR038466; S8_pro-domain_sf.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR PANTHER; PTHR42884:SF28; PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 7; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF16470; S8_pro-domain; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}.
FT DOMAIN 500..637
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT REGION 214..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 206
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 247
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 425
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 760 AA; 84294 MW; A2DCE5501748600E CRC64;
MQNLKSYGPL WGVTMEATLS TYQCLWLTLA WIFVFTQHAC ISAWALELPA GGYRTGQSSE
HEEQSPSPGH LTWAVHLDLT DGISDKENLD FLASQVAEAA GLENRGQIGE LHGRYLFAHP
CHDLEEEGRN RIKELADNVL SQHDSVRWHS EQRLLKRSKR SLQFNDPKYP QQWHLHNKKT
LGMDINITGV WERNVTGKNV TVVVVDDGVE HTLKDIQPNY SPEGSYDLNS NDPDPMPHPD
AENDNHHGTR CAGEIAAAPN NSFCAVGVAY GSRIAGIRVL DGPLTDSMEA IAFNKHYQIN
DIYSCSWGPD DDGKTVDGPH PLGKAALQHG VIAGRKGFGS IFVVASGNGG QYSDNCNYDG
YANSVYTITI GAVDEAGNMP FYAEECSSML AVTFSSGNKM MRSIVTSDWD MMKGTGCTEG
HTGTSAAAPI ATGMIALMLQ VRPCLTWRDV QHIIAFTASK YDDRPAAWET NGANFSHSHQ
HGFGLLNAWR LVNAAKVWES VPYLASYVSP VLREDKTIPL VKNLLEVFWN VTAADLKLSG
LKTLEHVLVA VTITHPRRGN LEIELFCPSN MSSLIGATRT MDSDSSGYVD WTFSTVRCWG
ERAEGTYKMT VTDYGDGILK QGTLKQWQLT LYGSSWTSEE VKQRQELVEE AMSGRYLNDS
FSLPCPPGLV ILERETYTIS TNTLKTLVLL GCFAVFWSLY YILEVCFTRK DIGFELVCNT
PRCRRYEGSS TPRSIEEAAV IESLPLCRAE ESTMESLEQE
//
