ID H3BHD5_LATCH Unreviewed; 266 AA.
AC H3BHD5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Neuralized E3 ubiquitin protein ligase 2 {ECO:0000313|Ensembl:ENSLACP00000021306.1};
GN Name=NEURL2 {ECO:0000313|Ensembl:ENSLACP00000021306.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000021306.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000021306.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AFYH01003902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005986772.1; XM_005986710.2.
DR AlphaFoldDB; H3BHD5; -.
DR STRING; 7897.ENSLACP00000021306; -.
DR Ensembl; ENSLACT00000021447.1; ENSLACP00000021306.1; ENSLACG00000018723.1.
DR GeneID; 102354366; -.
DR KEGG; lcm:102354366; -.
DR CTD; 140825; -.
DR eggNOG; KOG4625; Eukaryota.
DR GeneTree; ENSGT00940000159689; -.
DR HOGENOM; CLU_091737_1_0_1; -.
DR InParanoid; H3BHD5; -.
DR OMA; RIGIIYV; -.
DR OrthoDB; 3661067at2759; -.
DR TreeFam; TF314368; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000018723; Expressed in muscle tissue and 5 other cell types or tissues.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd12887; SPRY_NHR_like; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR037962; Neuralized.
DR InterPro; IPR006573; NHR_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR12429; NEURALIZED; 1.
DR PANTHER; PTHR12429:SF8; NEURALIZED-LIKE PROTEIN 2; 1.
DR Pfam; PF07177; Neuralized; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00588; NEUZ; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS51065; NHR; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 8..225
FT /note="NHR"
FT /evidence="ECO:0000259|PROSITE:PS51065"
FT DOMAIN 231..266
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
SQ SEQUENCE 266 AA; 30429 MW; D1C80C8F5049EA00 CRC64;
MAAFSNPYMQ FHSIHGTNIR IDPSQTQATR VESFANGVCF SKWPLEPGQI FLVEIEEKEL
GWCGHLRIGL TAQDPRTLEA VPEYSLPDLV NLSNSWIFAI TRNHNKIAKE NNEENDFKPK
SFFTDAYLQI EEFKVPRDKL VGRSRPGRYS HILDDLYKTN TLPPTARRSR IGVLYITRSD
GTGNMHIIIN GEDMGPSARG LPTNQPLYAV VDIFASTKSV RIIQVEHGFP SLQTLCRQTI
QKHIVHRLAI DWLELPEFLK NFCKYE
//
