ID H3BKC4_MOUSE Unreviewed; 591 AA.
AC H3BKC4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Amiloride-sensitive sodium channel subunit alpha {ECO:0000256|ARBA:ARBA00040202};
DE AltName: Full=Alpha-NaCH {ECO:0000256|ARBA:ARBA00042253};
DE AltName: Full=Epithelial Na(+) channel subunit alpha {ECO:0000256|ARBA:ARBA00041738};
DE AltName: Full=Nonvoltage-gated sodium channel 1 subunit alpha {ECO:0000256|ARBA:ARBA00043048};
DE AltName: Full=SCNEA {ECO:0000256|ARBA:ARBA00041933};
DE Flags: Fragment;
GN Name=Scnn1a {ECO:0000313|Ensembl:ENSMUSP00000135336.2,
GN ECO:0000313|MGI:MGI:101782};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000135336.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000135336.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000135336.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000135336.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000135336.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004424}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Cell projection, cilium, flagellum
CC {ECO:0000256|ARBA:ARBA00004230}. Cytoplasmic granule
CC {ECO:0000256|ARBA:ARBA00004463}. Cytoplasmic vesicle, secretory
CC vesicle, acrosome {ECO:0000256|ARBA:ARBA00004218}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. SCNN1A subfamily. {ECO:0000256|ARBA:ARBA00037944}.
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DR AlphaFoldDB; H3BKC4; -.
DR SMR; H3BKC4; -.
DR ProteomicsDB; 326877; -.
DR Antibodypedia; 2337; 383 antibodies from 34 providers.
DR Ensembl; ENSMUST00000176442.8; ENSMUSP00000135336.2; ENSMUSG00000030340.17.
DR AGR; MGI:101782; -.
DR MGI; MGI:101782; Scnn1a.
DR VEuPathDB; HostDB:ENSMUSG00000030340; -.
DR GeneTree; ENSGT00940000160952; -.
DR HOGENOM; CLU_020415_0_0_1; -.
DR OMA; MRQCKQE; -.
DR ChiTaRS; Scnn1a; mouse.
DR Proteomes; UP000000589; Chromosome 6.
DR Bgee; ENSMUSG00000030340; Expressed in granulocyte and 74 other cell types or tissues.
DR ExpressionAtlas; H3BKC4; baseline and differential.
DR GO; GO:0001669; C:acrosomal vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:InterPro.
DR GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR004724; ENaC_chordates.
DR InterPro; IPR020903; ENaC_CS.
DR NCBIfam; TIGR00859; ENaC; 1.
DR PANTHER; PTHR11690:SF124; AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR PROSITE; PS01206; ASC; 1.
PE 1: Evidence at protein level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Flagellum {ECO:0000256|ARBA:ARBA00022846};
KW Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Proteomics identification {ECO:0007829|ProteomicsDB:H3BKC4};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022480};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Taste {ECO:0000256|ARBA:ARBA00022480};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022461}.
FT REGION 105..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..563
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 591
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000135336.2"
SQ SEQUENCE 591 AA; 66637 MW; 4D0542B355AC3DDC CRC64;
MKTAFWAVLW LCTFGMMYWQ FALLFEEYFS YPVSLNINLN SDKLVFPAVT VCTLNPYRYT
EIKEDLEELD RITEQTLFDL YKYNSSYTRQ AGGRRRSTRD LRGALPHPLQ RLRTPPPPNP
ARSARSASSS VRDNNPQVDR KDWKIGFQLC NQNKSDCFYQ TYSSGVDAVR EWYRFHYINI
LSRLPDTSPA LEEEALGSFI FTCRFNQAPC NQANYSQFHH PMYGNCYTFN NKNNSNLWMS
SMPGVNNGLS LTLRTEQNDF IPLLSTVTGA RVMVHGQDEP AFMDDGGFNV RPGVETSISM
RKEALDSLGG NYGDCTENGS DVPVKNLYPS KYTQQVCIHS CFQENMIKKC GCAYIFYPKP
KGVEFCDYLK QSSWGYCYYK LQAAFSLDSL GCFSKCRKPC SVTNYKLSAG YSRWPSVKSQ
DWIFEMLSLQ NNYTINNKRN GVAKLNIFFK ELNYKTNSES PSVTMVSLLS NLGSQWSLWF
GSSVLSVVEM AELIFDLLVI TLIMLLHRFR SRYWSPGRGA RGAREVASTP ASSFPSRFCP
HPTSPPPSLP QQGTTPPLAL TAPPPAYATL GPSASPLDSA VPGSSACAPA M
//
