ID H3BLS7_HUMAN Unreviewed; 3210 AA.
AC H3BLS7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Vacuolar protein sorting 13 homolog D {ECO:0000313|Ensembl:ENSP00000011700.6};
DE Flags: Fragment;
GN Name=VPS13D {ECO:0000313|Ensembl:ENSP00000011700.6};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000011700.6, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000011700.6, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H.,
RA Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C.,
RA Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R.,
RA Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.,
RA Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.,
RA Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R.,
RA Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D.,
RA Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A.,
RA Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S.,
RA Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A.,
RA Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S.,
RA Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A.,
RA Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L.,
RA Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z.,
RA Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C.,
RA Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M.,
RA Langford C.F., Pandian R.D., Porter K.M., Prigmore E.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2] {ECO:0007829|PubMed:18669648}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [3] {ECO:0007829|PubMed:19690332}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [4] {ECO:0007829|PubMed:19608861}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
RA Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [5] {ECO:0007829|PubMed:21406692}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [6] {ECO:0007829|PubMed:23186163}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23186163;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [7] {ECO:0007829|PubMed:24275569}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [8] {ECO:0000313|Ensembl:ENSP00000011700.6}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
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DR EMBL; AC243836; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL031276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX682532; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; FO535326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; H3BLS7; -.
DR MaxQB; H3BLS7; -.
DR PeptideAtlas; H3BLS7; -.
DR ProteomicsDB; 40705; -.
DR Antibodypedia; 63052; 64 antibodies from 9 providers.
DR Ensembl; ENST00000011700.10; ENSP00000011700.6; ENSG00000048707.15.
DR UCSC; uc057cjn.1; human.
DR HGNC; HGNC:23595; VPS13D.
DR VEuPathDB; HostDB:ENSG00000048707; -.
DR GeneTree; ENSGT00950000183083; -.
DR HOGENOM; CLU_000131_0_0_1; -.
DR ChiTaRS; VPS13D; human.
DR Proteomes; UP000005640; Chromosome 1.
DR Bgee; ENSG00000048707; Expressed in skin of leg and 204 other cell types or tissues.
DR ExpressionAtlas; H3BLS7; baseline and differential.
DR CDD; cd14306; UBA_VP13D; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR041969; VP13D_UBA.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF93; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF00627; UBA; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF06650; VPS13_VAB; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50030; UBA; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:H3BLS7,
KW ECO:0007829|MaxQB:H3BLS7};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 1456..1499
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT REGION 386..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 894..966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 894..911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 942..966
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000011700.6"
SQ SEQUENCE 3210 AA; 357031 MW; 9540F413A61E0910 CRC64;
XRTVGMANRE KYGRKIATAS IGGTKVNVSM GSTFDMNGSL GCLQLMDLTQ DNVKNQYVVS
IGNSVGYENI ISDIGYFESV FVRMEDAALT EALSFTFVER SKQECFLNLK MASLHYNHSA
KFLKELTLSM DELEENFRGM LKSAATKVTT VLATKTAEYS EMVSLFETPR KTREPFILEE
NEIYGFDLAS SHLDTVKLIL NINIESPVVS IPRKPGSPEL LVGHLGQIFI QNFVAGDDES
RSDRLQVEIK DIKLYSLNCT QLAGREAVGS EGSRMFCPPS GSGSANSQEE AHFTRHDFFE
SLHRGQAFHI LNNTTIQFKL EKIPIERESE LTFSLSPDDL GTSSIMKIEG KFVNPVQVVL
AKHVYEQVLQ TLDNLVYSED LNKYPASATS SPCPDSPLPP LSTCGESSVE RKENGLFSHS
SLSNTSQKSL SVKEVKSFTQ IQATFCISEL QVQLSGDLTL GAQGLVSLKF QDFEVEFSKD
HPQTLSIQIA LHSLLMEDLL EKNPDSKYKN LMVSRGAPKP SSLAQKEYLS QSCPSVSNVE
YPDMPRSLPS HMEEAPNVFQ LYQRPTSASR KKQKEVQDKD YPLTPPPSPT VDEPKILVGK
SKFDDSLVHI NIFLVDKKHP EFSSSYNRVN RSIDVDFNCL DVLITLQTWV VILDFFGIGS
TADNHAMRLP PEGILHNVKL EPHASMESGL QDPVNTKLDL KVHSLSLVLN KTTSELAKAN
VSKLVAHLEM IEGDLALQGS IGSLSLSDLT CHGEFYRERF TTSGEEALIF QTFKYGRPDP
LLRREHDIRV SLRMASVQYV HTQRFQAEVV AFIQHFTQLQ DVLGRQRAAI EGQTVRDQAQ
RCSRVLLDIE AGAPVLLIPE SSRSNNLIVA NLGKLKVKNK FLFAGFPGTF SLQDKESVPS
ASPTGIPKHS LRKTTSTEEP RGTHSQGQFT MPLAGMSLGS LKSEFVPSTS TKQQGPQPTL
SVGQESSSPE DHVCLLDCVV VDLQDMDIFA AERHPREYSK APEDSSGDLI FPSYFVRQTG
GSLLTEPCRL KLQVERNLDK EISHTVPDIS IHGNLSSVHC SLDLYKYKLI RGLLENNLGE
PIEEFMRPYD LQDPRIHTVL SGEVYTCMCF LIDMVNVSLE LKDPKRKEGA GSLARFDFKK
CKLLYESFSN QTKSINLVSH SMMAFDTRYA GQKTSPGMTN VFSCIFQPAK NSSTTQGSIQ
IELHFRSTKD SSCFTVVLNN LRVFLIFDWL LLVHDFLHTP SDIKKQNHVT PSRHRNSSSE
SAIVPKTVKS GVVTKRSSLP VSNERHLEVK VNVTGTEFVV IEDVSCFDTN AIILKGTTVL
TYKPRFVDRP FSGSLFGIEV FSCRLGNEHD TALSIVDPVQ IQMELVGNSS YQNSSGLMDA
FNSEDFPPVL EIQLQALDIR LSYNDVQLFL AIAKSIPEQA NAAVPDSVAL ESDSVGTYLP
GASRVGEEIR EGTRHTLDPV LELQLARLQE LGFSMDDCRK ALLACQGQLK KAASWLFKNA
EPLKSLSLAS TSRDSPGAVA APLISGVEIK AESVCICFID DCMDCDVPLA ELTFSRLNFL
QRVRTSPEGY AHFTLSGDYY NRALSGWEPF IEPWPCSVSW QQQAASRLHP PRLKLEAKAK
PRLDINITSV LIDQYVSTKE SWMADYCKDD KDIESAKSED WMGSSVDPPC FGQSLPLVYL
RTRSTASLTN LEHQIYAREV KTPKRRQPFV PFALRNHTGC TLWFATLTTT PTRAALSHSG
SPGVVPEGNG TFLDDTHNVS EWREVLTGEE IPFEFEARGK LRHRHTHDLR IHQLQVRVNG
WEQVSPVSVD KVGTFFRYAA PDKNSSSSTI GSPSSRTNII HPQVYFSSLP PVRVVFAVTM
EGSARKVITV RSALIVRNRL ETPMELRLDS PSAPDKPVVL PAIMPGDSFA VPLHLTSWRL
QARPKGLGVF FCKAPIHWTN VVKTAEISSS KRECHSMDTE KSRFFRFCVA IKKENYPDYM
PSNIFSDSAK QIFRQPGHTI YLLPTVVICN LLPCELDFYV KGMPINGTLK PGKEAALHTA
DTSQNIELGV SLENFPLCKE LLIPPGTQNY MVRMRLYDVN RRQLNLTIRI VCRAEGSLKI
FISAPYWLIN KTGLPLIFRQ DNAKTDAAGQ FEEHELARSL SPLLFCYADK EQPNLCTMRI
GRGIHPEGMP GWCQGFSLDG GSGVRALKVI QQGNRPGLIY NIGIDVKKGR GRYIDTCMVI
FAPRYLLDNK SSHKLAFAQR EFARGQGTAN PEGYISTLPG SSVVFHWPRN DYDQLLCVRL
MDVPNCIWSG GFEVNKNNSF HINMRDTLGK CFFLRVEITL RGATYRISFS DTDQLPPPFR
IDNFSKVPVV FTQHGVAEPR LRTEVKPMTS LDYAWDEPTL PPFITLTVKG AGSSEINCNM
NDFQDNRQLY YENFIYIAAT YTFSGLQEGT GRPVASNKAI TCAELVLDVS PKTQRVILKK
KEPGKRSQLW RMTGTGMLAH EGSSVPHNPN KPSAARSTEG SAILDIAGLA AVTDNRYEPL
MLRKPDRRRS TTQTWSFREG KLTCGLHGLV VQAKGGLSGL FDGAEVVLGP DTSMELLGPV
PPEQQFINQK MRPGSGMLSI RVIPDGPTRA LQITDFCHRK SSRSYEVDEL PVTEQELQKL
KNPDTEQELE VLVRLEGGIG LSLINKVPEE LVFASLTGIN VHYTQLATSH MLELSIQDVQ
VDNQLIGTTQ PFMLYVTPLS NENEVIETGP AVQVNAVKFP SKSALTNIYK HLMITAQRFT
VQIEEKLLLK LLSFFGYDQA ESEVEKYDEN LHEKTAEQGG TPIRYYFENL KISIPQIKLS
VFTSNKLPLD LKALKSTLGF PLIRFEDAVI NLDPFTRVHP YETKEFIIND ILKHFQEELL
SQAARILGSV DFLGNPMGLL NDVSEGVTGL IKYGNVGGLI RNVTHGVSNS AAKFAGTLSD
GLGKTMDNRH QSEREYIRYH AATSGEHLVA GIHGLAHGII GGLTSVITST VEGVKTEGGV
SGFISGLGKG LVGTVTKPVA GALDFASETA QAVRDTATLS GPRTQAQRVR KPRCCTGPQG
LLPRYSESQA EGQEQLFKLT DNIQDEFFIA VENIDSYCVL ISSKAVYFLK SGDYVDREAI
FLEVKYDDLY HCLVSKDHGK VYVQVTKKAV STSSGVSIPG PSHQKPMVHV KSEVLAVKLS
QEINYAKSLY YEQQLMLRLS ENREQLELDS
//
