GenomeNet

Database: UniProt
Entry: H3BP77_HUMAN
LinkDB: H3BP77_HUMAN
Original site: H3BP77_HUMAN 
ID   H3BP77_HUMAN            Unreviewed;       282 AA.
AC   H3BP77;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   20-JUN-2018, entry version 43.
DE   SubName: Full=Thymidine kinase 2, mitochondrial {ECO:0000313|Ensembl:ENSP00000455187};
GN   Name=TK2 {ECO:0000313|Ensembl:ENSP00000455187};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000455187, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000455187, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000455187}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
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DR   EMBL; AC010542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H3BP77; -.
DR   EPD; H3BP77; -.
DR   MaxQB; H3BP77; -.
DR   PeptideAtlas; H3BP77; -.
DR   PRIDE; H3BP77; -.
DR   Ensembl; ENST00000564917; ENSP00000455187; ENSG00000166548.
DR   UCSC; uc059vii.1; human.
DR   EuPathDB; HostDB:ENSG00000166548.15; -.
DR   HGNC; HGNC:11831; TK2.
DR   OpenTargets; ENSG00000166548; -.
DR   GeneTree; ENSGT00510000046588; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000166548; -.
DR   ExpressionAtlas; H3BP77; baseline and differential.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0019206; F:nucleoside kinase activity; IEA:InterPro.
DR   InterPro; IPR002624; DCK/DGK.
DR   InterPro; IPR031314; DNK_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01712; dNK; 1.
DR   PIRSF; PIRSF000705; DNK; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   1: Evidence at protein level;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW   Proteomics identification {ECO:0000213|EPD:H3BP77,
KW   ECO:0000213|MaxQB:H3BP77, ECO:0000213|PeptideAtlas:H3BP77};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN       53    277       dNK. {ECO:0000259|Pfam:PF01712}.
FT   NP_BIND      57     65       ATP. {ECO:0000256|PIRSR:PIRSR000705-3}.
FT   NP_BIND     192    196       ATP. {ECO:0000256|PIRSR:PIRSR000705-3}.
FT   ACT_SITE    133    133       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000705-1}.
SQ   SEQUENCE   282 AA;  32873 MW;  8BF53315B72D2A70 CRC64;
     MLLWPLRGWA ARALRCFGPG SRGSPASGPG PRRVQRRAWP PDKEQEKEKK SVICVEGNIA
     SGKTTCLEFF SNATDVEVLT EPVSKWRNVR GHNPLGLMYH DASRWGLTLQ TYVQLTMLDR
     HTRPQVSSVR LMERSIHSAR YIFVENLYRS GKMPEVDYVV LSEWFDWILR NMDVSVDLIV
     YLRTNPETCY QRLKKRCREE EKVIPLVGSA LSTPDRLLVF PWQEYLEAIH HLHEEWLIKG
     SLFPMAAPVL VIEADHHMER MLELFEQNRD RILTPENRKH CP
//
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