ID H3BQK9_HUMAN Unreviewed; 7592 AA.
AC H3BQK9;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Microtubule actin crosslinking factor 1 {ECO:0000313|Ensembl:ENSP00000455823.1};
GN Name=MACF1 {ECO:0000313|Ensembl:ENSP00000455823.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000455823.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0007829|PubMed:17081983}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT networks.";
RL Cell 127:635-648(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000455823.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H.,
RA Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C.,
RA Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R.,
RA Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.,
RA Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.,
RA Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R.,
RA Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D.,
RA Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A.,
RA Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S.,
RA Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A.,
RA Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S.,
RA Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A.,
RA Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L.,
RA Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z.,
RA Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C.,
RA Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M.,
RA Langford C.F., Pandian R.D., Porter K.M., Prigmore E.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3] {ECO:0007829|PubMed:18669648}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [4] {ECO:0007829|PubMed:19413330}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [5] {ECO:0007829|PubMed:19690332}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [6] {ECO:0007829|PubMed:19608861}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
RA Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [7] {ECO:0007829|PubMed:20068231}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [8] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [9] {ECO:0007829|PubMed:21406692}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [10] {ECO:0007829|PubMed:23186163}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23186163;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [11] {ECO:0007829|PubMed:24275569}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [12] {ECO:0007829|PubMed:25944712}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
RN [13] {ECO:0000313|Ensembl:ENSP00000455823.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; AL137853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL355477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL356055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL365277; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL442071; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF495921; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; H3BQK9; -.
DR IntAct; H3BQK9; 1.
DR MassIVE; H3BQK9; -.
DR MaxQB; H3BQK9; -.
DR PeptideAtlas; H3BQK9; -.
DR ProteomicsDB; 41815; -.
DR Antibodypedia; 31853; 79 antibodies from 18 providers.
DR Ensembl; ENST00000567887.5; ENSP00000455823.1; ENSG00000127603.32.
DR UCSC; uc057ezv.1; human.
DR HGNC; HGNC:13664; MACF1.
DR VEuPathDB; HostDB:ENSG00000127603; -.
DR GeneTree; ENSGT00940000155824; -.
DR HOGENOM; CLU_000015_0_1_1; -.
DR OMA; SDFINME; -.
DR PhylomeDB; H3BQK9; -.
DR ChiTaRS; MACF1; human.
DR Proteomes; UP000005640; Chromosome 1.
DR Bgee; ENSG00000127603; Expressed in inferior olivary complex and 212 other cell types or tissues.
DR ExpressionAtlas; H3BQK9; baseline and differential.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd21240; CH_MACF1_rpt2; 1.
DR CDD; cd21188; CH_PLEC-like_rpt1; 1.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 16.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 33.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.920.20; Gas2-like domain; 1.
DR Gene3D; 3.90.1290.10; Plakin repeat; 5.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR003108; GAR_dom.
DR InterPro; IPR036534; GAR_dom_sf.
DR InterPro; IPR049538; PCN-like_spectrin-like_rpt.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF23; SHORT STOP, ISOFORM H; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF02187; GAS2; 1.
DR Pfam; PF00681; Plectin; 10.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF00435; Spectrin; 17.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21019; Spectrin_3; 1.
DR Pfam; PF21020; Spectrin_4; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM01129; DELLA; 1.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00243; GAS2; 1.
DR SMART; SM00250; PLEC; 20.
DR SMART; SM00150; SPEC; 34.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF143575; GAS2 domain-like; 1.
DR SUPFAM; SSF75399; Plakin repeat; 6.
DR SUPFAM; SSF46966; Spectrin repeat; 32.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS51460; GAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|EPD:H3BQK9,
KW ECO:0007829|MaxQB:H3BQK9};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 78..213
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 226..330
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 900..957
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 7179..7214
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 7215..7250
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 7255..7333
FT /note="GAR"
FT /evidence="ECO:0000259|PROSITE:PS51460"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2083..2124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3045..3066
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3136..3206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3353..3382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5724..5744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7089..7119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7336..7427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7447..7592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 509..561
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1435..1465
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1529..1574
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3427..3454
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3600..3638
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3728..3762
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3892..3922
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4286..4353
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4715..4790
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 5028..5069
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 6229..6256
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 8..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2085..2108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3157..3196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5728..5743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7343..7359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7391..7427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7462..7507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7539..7592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 7592 AA; 861078 MW; 2189899D37DA6FAC CRC64;
MSSSDEETLS ERSCRSERSC RSERSYRSER SGSLSPCPPG DTLPWNLPLH EQKKRKSQDS
VLDPAERAVV RVADERDRVQ KKTFTKWVNK HLMKVRKHIN DLYEDLRDGH NLISLLEVLS
GIKLEPAGLK TLRLVSMPSW CHTNNEEQAE EDDDDVPREK GRMRFHRLQN VQIALDFLKQ
RQVKLVNIRN DDITDGNPKL TLGLIWTIIL HFQISDIYIS GESGDMSAKE KLLLWTQKVT
AGYTGIKCTN FSSCWSDGKM FNALIHRYRP DLVDMERVQI QSNRENLEQA FEVAERLGVT
RLLDAEDVDV PSPDEKSVIT YVSSIYDAFP KVPEGGEGIS ATEVDSRWQE YQSRVDSLIP
WIKQHTILMS DKTFPQNPVE LKALYNQYIH FKETEILAKE REKGRIEELY KLLEVWIEFG
RIKLPQGYHP NDVEEEWGKL IIEMLEREKS LRPAVERLEL LLQIANKIQN GALNCEEKLT
LAKNTLQADA AHLESGQPVQ CESDVIMYIQ ECEGLIRQLQ VDLQILRDEN YYQLEELAFR
VMRLQDELVT LRLECTNLYR KGHFTSLELV PPSTLTTTHL KAEPLTKATH SSSTSWFRKP
MTRAELVAIS SSEDEGNLRF VYELLSWVEE MQMKLERAEW GNDLPSVELQ LETQQHIHTS
VEELGSSVKE ARLYEGKMSQ NFHTSYAETL GKLETQYCKL KETSSFRMRH LQSLHKFVSR
ATAELIWLNE KEEEELAYDW SDNNSNISAK RNYFSELTME LEEKQDVFRS LQDTAELLSL
ENHPAKQTVE AYSAAVQSQL QWMKQLCLCV EQHVKENTAY FQFFSDAREL ESFLRNLQDS
IKRKYSCDHN TSLSRLEDLL QDSMDEKEQL IQSKSSVASL VGRSKTIVQL KPRSPDHVLK
NTISVKAVCD YRQIEITICK NDECVLEDNS QRTKWKVISP TGNEAMVPSV CFLIPPPNKD
AIEMASRVEQ SYQKVMALWH QLHVNTKSLI SWNYLRKDLD LVQTWNLEKL RSSAPGECHQ
IMKNLQAHYE DFLQDSRDSV LFSVADRLRL EEEVEACKAR FQHLMKSMEN EDKEETVAKM
YISELKNIRL RLEEYEQRVV KRIQSLASSR TDRDAWQDNA LRIAEQEHTQ EDLQQLRSDL
DAVSMKCDSF LHQSPSSSSV PTLRSELNLL VEKMDHVYGL STVYLNKLKT VDVIVRSIQD
AELLVKGYEI KLSQEEVVLA DLSALEAHWS TLRHWLSDVK DKNSVFSVLD EEIAKAKVVA
EQMSRLTPER NLDLERYQEK GSQLQERWHR VIAQLEIRQS ELESIQEVLG DYRACHGTLI
KWIEETTAQQ EMMKPGQAED SRVLSEQLSQ QTALFAEIER NQTKLDQCQK FSQQYSTIVK
DYELQLMTYK AFVESQQKSP GKRRRMLSSS DAITQEFMDL RTRYTALVTL TTQHVKYISD
ALRRLEEEEK VVEEEKQEHV EKVKELLGWV STLARNTQGK ATSSETKEST DIEKAILEQQ
VLSEELTTKK EQVSEAIKTS QIFLAKHGHK LSEKEKKQIS EQLNALNKAY HDLCDGSANQ
LQQLQSQLAH QTEQKECRAV AGVIDLGTVE IFPIFKAMQK GLLDQDTGLV LLESQVIMSG
LIAPETGENL SLEEGIARNL INPQMYQQLR ELQDALALIS RLTESRGPLS VVEAIEKRII
SETVGLKILE AHLATGGFSL SPSENCINLE EAFHQGLISA WLHSVLESYL RTSKNLIDPN
TAEKIGLLDL MQRCIVHQES GFKLLPVKQL AGGMVSLKSG RKVSIFRAVQ EGLIDRQVTV
RLLEAQLFAG GIVDPRTGHR LTVEEAVRHN LIDQDMACAI LIRQLQTGGI IDTVTGQRLT
IDEAVSNDLV AAKIALVILE SLWSFMGLLW PESGEILPIT DALEQGIVST ELAHKILSNR
QHIKALFLPA TTEILSWKKA IESGILDRDL ANNLKSICIP DVMPHMQLAD SAEQNINPGA
AVLPCSKSHP KATASQSENL LFQLMTHSYI NVQNGQRLLL LDKELMETLT SRDEYQTSPP
KVVEIGHQRQ KTPEGLQESA NVKISGTFSS GWTVRLPEFQ FSSQNKEYPD REDCTTEKGK
KTTVETEDSS VENPEQDLFV EQKERNPNID ALKVINKVKL EVQRQLIGTQ REDQTAVSVR
ENASRGHLLT IPPAEAEGVP LVVDKDVFSV ETPKKEHQPL RNTSFTCQNE QAHTLETEYI
HDETGGSHIK PQSKKLQVQV KKTLGIKLEL KSETDGNVHP LDKKEMLKKT FLAKDDHKES
QEAQNIAGGS MMMSEKTDEE DSGREIFLSC SHPLELLEEA TLNVLSAQLL DGGIFHEQTG
QKLLLNEAIS RGIVPSHTAV KLMEKLNMFQ GFFDSQTCES LTTEEVINEG LMDEKLLHNV
LMADKAISGV LDPRTQTLCS VKDAVTVGLL DKETATRILE RQVVTGGIID LKRGKKVSVT
LASTLGLVDV ADQPELINLE KASKGRDAEK TVRERLISLQ METTGLIDPD SKAPLTVVQS
IDRGLLEREE AVRLLTKQVV DGGIIHHISG MRLSVDNAFR HGLIGEDLAE KLKRVENLNI
HQIFNPETKE NISLPKAIKL DLITSDLKRE IQEVQAFTGN FVDLISGQRL TLAEAKKEGL
LTNEAVLSPG MMHGIVDPEN CRIVPYSELV KKCKIDIESG QRYLEVIPFS DIKDGVSDKV
LTLSQAIQLG KVDFASTLKV LEAQANTGGI IDTATGKRLT LASALEEKLV DENMVRIIAS
HQVLNGGIVD IFSDQRVTLV EAIEKRLISP ELANMIQIDS SEFSDHRAQI EKQEGIEVCA
LQNEFLGKDM LIACNQTAEM SCNKVEESER LFQVENQSAQ EKVKVRVSDG EQAKKSREIS
LKEFGCKDQR KPRMSSDAKE FISIINPHNL KGKSLGQVSL THPYSECDFK LKEVARNNMG
NDTNEEQEKA VTKIEIISHM KQSTSCLDSE EIRENQGEVI LEVQETYCET SGKLPSEQVL
QQPMNARVKS KREKREVIVE ESIRTCKPAF LSEEKLYQET AIRDEHDSHI KSQPREMTSS
EKGKEADTEM GFSITFKIEE SSSQVVPQGI SVKHLDALTL FSSKQANEGK VNNLSLCLTL
KPEENLSREI ACGAQSEPFP CMTPRPEGLH YQESDGKAQV TGPSQISKTD KSFQGTTRQE
TNYQDSWVTS KTKETKHQIS SSNECKEKSY QEVSFDPARG LKLEEITVSR PDSKEVRYLE
FSDRKDLHHQ GSKSDDKLCG TLKSEIATQE LTGEKFLEMA NPNVAGLEAG SIEDIVTQRG
SRVLGSFLPE KLFKGVSQKE NTGQQNAIIS PTVLETSEEK TVSLTVCSAV KTEKTPQEKL
RESPGSEQTP FMTAPEGKGN GGVNPEPFRA TQNVFTRQLC LEHDEKLVSY LSLLRNIEMR
TKQIQPLELN LAELQDLLCQ AKVLERELKD LTTLVSQELE CVNQIIISQP QEVPAQLLKA
LEKDAKNLQK SLSSVSDTWN SRLLHFQNAV EIEKTKVLNQ HTQLEGRLQD LRAWVGNKNL
ILNSKGSNSE IDVDSLNLCL QQYEDLKQPM AERKAQLDAL AFDIQFFISE HAQDLSPQQN
RQMLRLLNEL QRSFQDILEQ TAAQVDALQG HLQQMEQEAL VKTLQKQQNT CHQQLEDLCS
WVGQAERALA GHQGRTTQQD LSALQKNQSD LKDLQDDIQN RATSFATVVK DIEGFMEENQ
TKLSPRELTA LREKLHQAKE QYEALQEETR VAQKELEEAV TSALQQETEK SKAAKELAEN
KKKIDALLDW VTSVGSSGGQ LLTNLPGMEQ LSGASLEKGA LDTTDGYMGV NQAPEKLDKQ
CEMMKARHQE LLSQQQNFIL ATQSAQAFLD QHGHNLTPEE QQMLQQKLGE LKEQYSTSLA
QSEAELKQVQ TLQDELQKFL QDHKEFESWL ERSEKELENM HKGGSSPETL PSLLKRQGSF
SEDVISHKGD LRFVTISGQK VLDMENSFKE GKEPSEIGNL VKDKLKDATE RYTALHSKCT
RLGSHLNMLL GQYHQFQNSA DSLQAWMQAC EANVEKLLSD TVASDPGVLQ EQLATTKQLQ
EELAEHQVPV EKLQKVARDI MEIEGEPAPD HRHVQETTDS ILSHFQSLSY SLAERSSLLQ
KAIAQSQSVQ ESLESLLQSI GEVEQNLEGK QVSSLSSGVI QEALATNMKL KQDIARQKSS
LEATREMVTR FMETADSTTA AVLQGKLAEV SQRFEQLCLQ QQEKESSLKK LLPQAEMFEH
LSGKLQQFME NKSRMLASGN QPDQDITHFF QQIQELNLEM EDQQENLDTL EHLVTELSSC
GFALDLCQHQ DRVQNLRKDF TELQKTVKER EKDASSCQEQ LDEFRKLVRT FQKWLKETEG
SIPPTETSMS AKELEKQIEH LKSLLDDWAS KGTLVEEINC KGTSLENLIM EITAPDSQGK
TGSILPSVGS SVGSVNGYHT CKDLTEIQCD MSDVNLKYEK LGGVLHERQE SLQAILNRME
EVHKEANSVL QWLESKEEVL KSMDAMSSPT KTETVKAQAE SNKAFLAELE QNSPKIQKVK
EALAGLLVTY PNSQEAENWK KIQEELNSRW ERATEVTVAR QRQLEESASH LACFQAAESQ
LRPWLMEKEL MMGVLGPLSI DPNMLNAQKQ QVQFMLKEFE ARRQQHEQLN EAAQGILTGP
GDVSLSTSQV QKELQSINQK WVELTDKLNS RSSQIDQAIV KSTQYQELLQ DLSEKVRAVG
QRLSVQSAIS TQPEAVKQQL EETSEIRSDL EQLDHEVKEA QTLCDELSVL IGEQYLKDEL
KKRLETVALP LQGLEDLAAD RINRLQAALA STQQFQQMFD ELRTWLDDKQ SQQAKNCPIS
AKLERLQSQL QENEEFQKSL NQHSGSYEVI VAEGESLLLS VPPGEEKRTL QNQLVELKNH
WEELSKKTAD RQSRLKDCMQ KAQKYQWHVE DLVPWIEDCK AKMSELRVTL DPVQLESSLL
RSKAMLNEVE KRRSLLEILN SAADILINSS EADEDGIRDE KAGINQNMDA VTEELQAKTG
SLEEMTQRLR EFQESFKNIE KKVEGAKHQL EIFDALGSQA CSNKNLEKLR AQQEVLQALE
PQVDYLRNFT QGLVEDAPDG SDASQLLHQA EVAQQEFLEV KQRVNSGCVM MENKLEGIGQ
FHCRVREMFS QLADLDDELD GMGAIGRDTD SLQSQIEDVR LFLNKIHVLK LDIEASEAEC
RHMLEEEGTL DLLGLKRELE ALNKQCGKLT ERGKARQEQL ELTLGRVEDF YRKLKGLNDA
TTAAEEAEAL QWVVGTEVEI INQQLADFKM FQKEQVDPLQ MKLQQVNGLG QGLIQSAGKD
CDVQGLEHDM EEINARWNTL NKKVAQRIAQ LQEALLHCGK FQDALEPLLS WLADTEELIA
NQKPPSAEYK VVKAQIQEQK LLQRLLDDRK ATVDMLQAEG GRIAQSAELA DREKITGQLE
SLESRWTELL SKAAARQKQL EDILVLAKQF HETAEPISDF LSVTEKKLAN SEPVGTQTAK
IQQQIIRHKA LEEDIENHAT DVHQAVKIGQ SLSSLTSPAE QGVLSEKIDS LQARYSEIQD
RCCRKAALLD QALSNARLFG EDEVEVLNWL AEVEDKLSSV FVKDFKQDVL HRQHADHLAL
NEEIVNRKKN VDQAIKNGQA LLKQTTGEEV LLIQEKLDGI KTRYADITVT SSKALRTLEQ
ARQLATKFQS TYEELTGWLR EVEEELATSG GQSPTGEQIP QFQQRQKELK KEVMEHRLVL
DTVNEVSRAL LELVPWRARE GLDKLVSDAN EQYKLVSDTI GQRVDEIDAA IQRSQQYEQA
ADAELAWVAE TKRKLMALGP IRLEQDQTTA QLQVQKAFSI DIIRHKDSMD ELFSHRSEIF
GTCGEEQKTV LQEKTESLIQ QYEAISLLNS ERYARLERAQ VLVNQFWETY EELSPWIEET
RALIAQLPSP AIDHEQLRQQ QEEMRQLRES IAEHKPHIDK LLKIGPQLKE LNPEEGEMVE
EKYQKAENMY AQIKEEVRQR ALALDEAVSQ STQFHDKIEP MLETLENLSS RLRMPPLIPA
EVDKIRECIS DNKSATVELE KLQPSFEALK RRGEELIGRS QGADKDLAAK EIQDKLDQMV
FFWEDIKARA EEREIKFLDV LELAEKFWYD MAALLTTIKD TQDIVHDLES PGIDPSIIKQ
QVEAAETIKE ETDGLHEELE FIRILGADLI FACGETEKPE VRKSIDEMNN AWENLNKTWK
ERLEKLEDAM QAAVQYQDTL QAMFDWLDNT VIKLCTMPPV GTDLNTVKDQ LNEMKEFKVE
VYQQQIEMEK LNHQGELMLK KATDETDRDI IREPLTELKH LWENLGEKIA HRQHKLEGAL
LALGQFQHAL EELMSWLTHT EELLDAQRPI SGDPKVIEVE LAKHHVLKND VLAHQATVET
VNKAGNELLE SSAGDDASSL RSRLEAMNQC WESVLQKTEE REQQLQSTLQ QAQGFHSEIE
DFLLELTRME SQLSASKPTG GLPETAREQL DTHMELYSQL KAKEETYNQL LDKGRLMLLS
RDDSGSGSKT EQSVALLEQK WHVVSSKMEE RKSKLEEALN LATEFQNSLQ EFINWLTLAE
QSLNIASPPS LILNTVLSQI EEHKVFANEV NAHRDQIIEL DQTGNQLKFL SQKQDVVLIK
NLLVSVQSRW EKVVQRSIER GRSLDDARKR AKQFHEAWKK LIDWLEDAES HLDSELEISN
DPDKIKLQLS KHKEFQKTLG GKQPVYDTTI RTGRALKEKT LLPEDSQKLD NFLGEVRDKW
DTVCGKSVER QHKLEEALLF SGQFMDALQA LVDWLYKVEP QLAEDQPVHG DLDLVMNLMD
AHKVFQKELG KRTGTVQVLK RSGRELIENS RDDTTWVKGQ LQELSTRWDT VCKLSVSKQS
RLEQALKQAE VFRDTVHMLL EWLSEAEQTL RFRGALPDDT EALQSLIDTH KEFMKKVEEK
RVDVNSAVAM GEVILAVCHP DCITTIKHWI TIIRARFEEV LTWAKQHQQR LETALSELVA
NAELLEELLA WIQWAETTLI QRDQEPIPQN IDRVKALIAE HQTFMEEMTR KQPDVDRVTK
TYKRKNIEPT HAPFIEKSRS GGRKSLSQPT PPPMPILSQS EAKNPRINQL SARWQQVWLL
ALERQRKLND ALDRLEELKE FANFDFDVWR KKYMRWMNHK KSRVMDFFRR IDKDQDGKIT
RQEFIDGILA SKFPTTKLEM TAVADIFDRD GDGYIDYYEF VAALHPNKDA YRPTTDADKI
EDEVTRQVAQ CKCAKRFQVE QIGENKYRFF LGNQFGDSQQ LRLVRILRST VMVRVGGGWM
ALDEFLVKND PCRVHHPGSK IKRSDSSSSI SSQSPIARGR TNIELREKFI LPEGASQGMT
PFRSRGRRSK PSSRAASPTR SSSSASQSNH SCTSMPSSPA TPASGTKTSL QFSRCYDKPW
LVNSKAGTPI RDSHSPDLQL PTPEVIPSSG SKLKRPTPTF HSSRTSLAGD TSNSSSPAST
GAKTNRADPK KSASRPGSRA GSRAGSRASS RRGSDASDFD LLETQSACSD TSESSAAGGQ
GNSRRGLNKP SKIPTMSKKT TTASPRTPGP KR
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