ID H3BU49_HUMAN Unreviewed; 123 AA.
AC H3BU49;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE RecName: Full=ADP-ribosylation factor-like protein 2-binding protein {ECO:0000256|ARBA:ARBA00014849, ECO:0000256|RuleBase:RU367099};
DE Short=ARF-like 2-binding protein {ECO:0000256|RuleBase:RU367099};
GN Name=ARL2BP {ECO:0000313|Ensembl:ENSP00000457465.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000457465.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000457465.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [2] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [3] {ECO:0007829|PubMed:23186163}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23186163;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [4] {ECO:0000313|Ensembl:ENSP00000457465.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Together with ARL2, plays a role in the nuclear
CC translocation, retention and transcriptional activity of STAT3. May
CC play a role as an effector of ARL2. {ECO:0000256|ARBA:ARBA00025341,
CC ECO:0000256|RuleBase:RU367099}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000256|ARBA:ARBA00004120, ECO:0000256|RuleBase:RU367099}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC {ECO:0000256|ARBA:ARBA00004300, ECO:0000256|RuleBase:RU367099}.
CC Cytoplasm {ECO:0000256|RuleBase:RU367099}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU367099}.
CC Mitochondrion intermembrane space {ECO:0000256|RuleBase:RU367099}.
CC -!- SIMILARITY: Belongs to the ARL2BP family.
CC {ECO:0000256|ARBA:ARBA00009880, ECO:0000256|RuleBase:RU367099}.
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DR EMBL; AC009090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3BU49; -.
DR SMR; H3BU49; -.
DR MassIVE; H3BU49; -.
DR MaxQB; H3BU49; -.
DR PeptideAtlas; H3BU49; -.
DR ProteomicsDB; 42827; -.
DR Antibodypedia; 28836; 367 antibodies from 25 providers.
DR Ensembl; ENST00000562023.5; ENSP00000457465.1; ENSG00000102931.8.
DR UCSC; uc059urb.1; human.
DR HGNC; HGNC:17146; ARL2BP.
DR VEuPathDB; HostDB:ENSG00000102931; -.
DR GeneTree; ENSGT00390000015052; -.
DR ChiTaRS; ARL2BP; human.
DR Proteomes; UP000005640; Chromosome 16.
DR Bgee; ENSG00000102931; Expressed in adrenal tissue and 198 other cell types or tissues.
DR ExpressionAtlas; H3BU49; baseline and differential.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-UniRule.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.1520.10; ADP-ribosylation factor-like 2-binding protein, domain; 1.
DR InterPro; IPR038849; ARL2BP.
DR InterPro; IPR023379; BART_dom.
DR InterPro; IPR042541; BART_sf.
DR PANTHER; PTHR15487; ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-BINDING PROTEIN; 1.
DR PANTHER; PTHR15487:SF5; ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-BINDING PROTEIN; 1.
DR Pfam; PF11527; ARL2_Bind_BART; 1.
PE 1: Evidence at protein level;
KW Cell projection {ECO:0000256|RuleBase:RU367099};
KW Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|RuleBase:RU367099};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU367099};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|RuleBase:RU367099};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128,
KW ECO:0000256|RuleBase:RU367099}; Nucleus {ECO:0000256|RuleBase:RU367099};
KW Proteomics identification {ECO:0007829|EPD:H3BU49,
KW ECO:0007829|MaxQB:H3BU49};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 32..94
FT /note="BART"
FT /evidence="ECO:0000259|Pfam:PF11527"
SQ SEQUENCE 123 AA; 13813 MW; 131DDFEF9175520B CRC64;
MDALEGESFA LSFSSASDAE FDAVVGYLED IIMEKYIEEQ LLQRIPEFNM AAFTTTLQHH
KDEVAGDIFD MLLTFTDFLA FKEMFLDYRA EKEGRGLDLS SGLVVTSLCK SSSLPASQNN
LRH
//